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Identification of Sildenafil (Viagra®) and its metabolite (UK-103,320) in six aviation fatalities

Author: Robert D Johnson; Russell J Lewis; United States. Office of Aerospace Medicine.; United States. Federal Aviation Administration.; Civil Aerospace Medical Institute.
Publisher: Washington, D.C. : Federal Aviation Administration, Office of Aerospace Medicine, Ft. Belvior, VA : Available to the public through the Defense Technical Information Center Springfield, Va. : Available to the public through the National Technical Information Service 2006.
Series: AD-a460 880.
Edition/Format:   Print book : National government publication : EnglishView all editions and formats
Summary:
During the investigation of aviation accidents, postmortem samples from victims are submitted to the Federal Aviation Administration's Civil Aerospace Medical Institute for toxicological analysis. This report presents a rapid and reliable method for the identification and quantitation of sildenafil (Viagra ) and its active metabolite, UK-103,320. This procedure utilizes sildenafil-d8 as an internal standard for more  Read more...
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Additional Physical Format: Johnson, Robert D.
Identification of Sildenafil (Viagra) and its metabolite (UK-103,320) in six aviation fatalities
i, 11 p.
(OCoLC)70119645
Material Type: Government publication, National government publication, Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Robert D Johnson; Russell J Lewis; United States. Office of Aerospace Medicine.; United States. Federal Aviation Administration.; Civil Aerospace Medical Institute.
OCLC Number: 65189614
Notes: Cover title.
"February 2006."
Performed by FAA Civil Aerospace Medical Institute, Oklahoma City, OK.
"DOT/FAA/AM-06/3."
Description: i, 11 pages : illustrations ; 28 cm.
Series Title: AD-a460 880.
Responsibility: Robert D. Johnson, Russell J. Lewis.
More information:

Abstract:

During the investigation of aviation accidents, postmortem samples from victims are submitted to the Federal Aviation Administration's Civil Aerospace Medical Institute for toxicological analysis. This report presents a rapid and reliable method for the identification and quantitation of sildenafil (Viagra ) and its active metabolite, UK-103,320. This procedure utilizes sildenafil-d8 as an internal standard for more accurate and reliable quantitation. The method incorporates solid-phase extraction and LC/MS/MS and MS/MS/MS utilizing an atmospheric pressure chemical ionization ion trap mass spectrometer in the positive chemical ionization mode. Solid-phase extraction provided an efficient sample extraction yielding recoveries ranging from 79 - 88%. The limit of detection for sildenafil and UK-103,320 was 0.39 and 0.19 ng/mL, respectively. The linear dynamic range for both compounds was 0.78 - 800 ng/mL. The method was employed for the determination of sildenafil and UK-103,320 in postmortem fluid and tissue specimens collected from 6 fatal aviation accident victims. The current method proved to be simple, accurate, and robust for the identification and quantitation of sildenafil and UK-103,320 in postmortem fluids and tissues.

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