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Imaging the aging brain

Author: William Jagust; Mark D'Esposito
Publisher: New York : Oxford University Press, 2009.
Edition/Format:   Print book : EnglishView all editions and formats
Summary:
"The importance of brain imaging for clinical diagnosis and the understanding of basic mechanisms of disease and aging is well-known in medical science. These techniques have been the basis for numerous studies that have striven to better detect neurological disorders and age-related change in the brain." "This book - co-edited by world-renowned Alzheimer's disease researcher and clinician, William Jagust, and  Read more...
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Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: William Jagust; Mark D'Esposito
ISBN: 9780195328875 0195328876
OCLC Number: 280353261
Description: xiii, 368 pages : illustrations (some color) ; 29 cm
Contents: Introduction: still more questions than answers / William Jagust and Mark D'Esposito --
Methodological and conceptual issues in the study of the aging brain / Mark D'Esposito, William Jagust, and Adam H. Gazzaley --
Neuropathology of aging / Dara L. Dickstein, John H. Morrison, and Patrick R. Hof --
A systems approach to the aging brain : neuroanatomic changes, their modifiers, and cognitive correlates / Naftali Raz and Kristen M. Kennedy --
Dopaminergic modulation of cognition in human aging / Shu-Chen Li [and others] --
Cognitive reserve and aging / Yaakov Stern --
Compensatory reorganization of brain networks in older adults / Cheryl L. Grady --
Cross-species imaging applied to the aging brain : dissociating Alzheimer's disease from normal aging / Sidonie T. Jones and Scott A. Small --
Genetics and imaging in Alzheimer's disease / Susan Y. Bookheimer --
Imaging cognitive decline in aging : predicting decline with structural imaging / Jeffrey Kaye --
The early detection of Alzheimer's disease with positron emission tomography / Rachel Mistur [and others] --
Structural imaging of mild cognitive impairment / Clifford R. Jack, Jr. --
Functional imaging with FDG-PET in mild cognitive impairment / Karl Herholz --
Amyloid imaging and (what is "normal"?) aging / William E. Klunk and Chester A. Mathis --
Differential diagnosis of dementia using functional neuroimaging / Eric Salmon, Fabienne Collette, and Gaëtan Garraux --
MRI and the differential diagnosis of dementia / António J. Bastos-Leite and Philip Scheltens --
White matter hyperintensities in aging and dementia / Adriane Mayda, Mitsuhiro Yoshita, and Charles DeCarli --
Functional MRI studies in aging and early Alzheimer's disease : predicting clinical decline / Reisa Sperling --
MRI as a surrogate marker in clinical trials in Alzheimer's disease / Frank Jessen and Harald Hampel --
Brain imaging in the evaluation of putative Alzheimer's disease-slowing, risk-reducing and prevention therapies / Eric M. Reiman and Jessica B.S. Langbaum --
Databasing the aging brain / John Darrell Van Horn and Arthur W. Toga.
Responsibility: edited by William Jagust, Mark D'Esposito.

Abstract:

"The importance of brain imaging for clinical diagnosis and the understanding of basic mechanisms of disease and aging is well-known in medical science. These techniques have been the basis for numerous studies that have striven to better detect neurological disorders and age-related change in the brain." "This book - co-edited by world-renowned Alzheimer's disease researcher and clinician, William Jagust, and world-renowned neurologist and cognitive neuroscientist, Mark D'Esposito - contains chapters from experts in the fields of brain imaging, clinical neuroscience, and cognitive neuroscience who have studied the aging brain. Topics covered include technical factors in brain imaging, pathological basis of age-related structural and functional changes, neurochemistry and genetics of brain imaging in aging, and the use of imaging techniques in diagnosis, longitudinal testing, drug development and testing, and presymptomatic detection. The book is intended to be both a detailed review of the current status of brain imaging and aging and to serve as an introduction to the field for those who may be starting investigations using imaging techniques of PET, structural MRI, and functional MRI. It covers basic science approaches such as using fMRI to probe networks, as well as recent developments such as amyloid imaging and the use of imaging as a biomarker in clinical trials." "The field of brain aging is undergoing rapid expansion because of new techniques such as fMRI and amyloid imaging which have been applied to both basic and clinical problems. Imaging the Aging Brain is a compendium of relevant knowledge and up-to-date analysis. Written by leaders in neurological research and presented in color, this book is as timely as it is thorough."--Jacket.

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