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Author: William E Paul
Publisher: Baltimore : Johns Hopkins University Press, 2018.
Edition/Format:   Print book : English : Johns Hopkins Paperback editionView all editions and formats
"The immune system has incredible power to protect us from the ravages of infection. Boosted by vaccines, it can protect us individually and as a "herd" from diseases such as measles. However, the power of the immune system is a double-edged sword: an overactive immune system can wreak havoc, destroying normal tissue and causing diseases such as type I diabetes, rheumatoid arthritis, and multiple sclerosis. The  Read more...

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Document Type: Book
All Authors / Contributors: William E Paul
ISBN: 9781421425283 1421425289
OCLC Number: 1030892801
Description: xiii, 260 pages : illustrations ; 23 cm
Contents: Part 1. Immunology : Defense and danger ; Tracing an immune response ; The laws of immunology: universality, tolerance, and appropriateness ; Growing up and learning immunology --
Part 2. The first law: universality : Vaccines and serum therapy ; How is specificity achieved? ; Immunology's "eureka": clonal selection ; How does each lymphocyte develop a distinct receptor? ; B cells and T cells recognize different types of antigens ; My foray into the specificity problem ; Genes and immune response ; The Laboratory of Immunology and the T-cell receptor --
Part 3. The second law: tolerance ; What is tolerance? ; How does tolerance develop? ; Regulatory T cells and the prevention of autoimmunity --
Part 4. The third law: appropriateness : Different structures, different functions ; Specific types of infections, specific types of T-cell responses ; Our discovery of IL-4 and the cells that make it ; CD8 T cells: killer cells and friends ; Dendritic cells: the cells that interpret the infectious threat --
Part 5. How did the immune system evolve? : An "ancient" immune response controls "modern" immunity ; The microbiome and innate immunity ; Evolution of the immune system and innate lymphoid cells --
Part 6. AIDS, autoimmunity, allergy, cancer, and transplantation : The HIV epidemic and the Office of AIDS Research ; How the immune system causes rheumatoid arthritis and lupus ; Allergy and asthma ; Interleukin-4 and allergy ; Can the immune system control cancer? ; New parts for old: bone marrow and organ transplantation ; Julien --
Conclusion. The future of immunology.
Responsibility: William E. Paul, MD.


Paul argues that we must take advantage of cutting-edge technologies and promising new tools in immunological research.  Read more...


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An excellent overview of what science knows about immunology today. * Science-Based Medicine * Written by a prominent researcher and scholar who not only followed the history of immunology but also Read more...

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