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Author: William E Paul
Publisher: Baltimore : Johns Hopkins University Press, [2015]
Edition/Format:   Print book : EnglishView all editions and formats
"The immune system has incredible power to protect us from the ravages of infection. Boosted by vaccines, it can protect us individually and as a "herd" from diseases such as measles. However, the power of the immune system is a double-edged sword: an overactive immune system can wreak havoc, destroying normal tissue and causing diseases such as type I diabetes, rheumatoid arthritis, and multiple sclerosis. The  Read more...

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Document Type: Book
All Authors / Contributors: William E Paul
ISBN: 9781421418018 1421418010
OCLC Number: 900869876
Description: xiii, 260 pages : illustrations ; 24 cm
Contents: Part 1. Immunology : Defense and danger ; Tracing an immune response ; The laws of immunology: universality, tolerance, and appropriateness ; Growing up and learning immunology --
Part 2. The first law: universality : Vaccines and serum therapy ; How is specificity achieved? ; Immunology's "eureka": clonal selection ; How does each lymphocyte develop a distinct receptor? ; B cells and T cells recognize different types of antigens ; My foray into the specificity problem ; Genes and immune response ; The Laboratory of Immunology and the T-cell receptor --
Part 3. The second law: tolerance ; What is tolerance? ; How does tolerance develop? ; Regulatory T cells and the prevention of autoimmunity --
Part 4. The third law: appropriateness : Different structures, different functions ; Specific types of infections, specific types of T-cell responses ; Our discovery of IL-4 and the cells that make it ; CD8 T cells: killer cells and friends ; Dendritic cells: the cells that interpret the infectious threat --
Part 5. How did the immune system evolve? : An "ancient" immune response controls "modern" immunity ; The microbiome and innate immunity ; Evolution of the immune system and innate lymphoid cells --
Part 6. AIDS, autoimmunity, allergy, cancer, and transplantation : The HIV epidemic and the Office of AIDS Research ; How the immune system causes rheumatoid arthritis and lupus ; Allergy and asthma ; Interleukin-4 and allergy ; Can the immune system control cancer? ; New parts for old: bone marrow and organ transplantation ; Julien --
Conclusion. The future of immunology.
Responsibility: William E. Paul, MD.


Paul argues that we must position ourselves to take advantage of cutting-edge technologies and promising new tools in immunological research, including big data and the microbiome.  Read more...


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An excellent overview of what science knows about immunology today. -- Harriet Hall Science-Based Medicine Written by a prominent researcher and scholar who not only followed the history of Read more...

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