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In vivo models to study angiogenesis

Author: Domenico Ribatti
Publisher: London : Academic Press, an imprint of Elsevier, [2017] ©2018
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
In Vivo Models to Study Angiogenesis provides the latest information and an overview of the most common assays for studying angiogenesis in vivo. Under physiological conditions, angiogenesis is tightly controlled, whereas increased production of angiogenic stimuli and/or reduced production of angiogenic inhibitors leads to abnormal neovascularization, such as occurs in cancer, chronic inflammatory disease, diabetic  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
(OCoLC)983310518
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Domenico Ribatti
ISBN: 9780128140215 0128140216
OCLC Number: 1001728315
Description: 1 online resource : color illustrations
Contents: The chick embryo chorioallantoic membrane --
The corneal assay for angiogenesis --
The matrigel implant assay --
The sponge implant model --
The disk angiogenesis system --
The drosal air sac model --
The chamber assays --
The zebrafish --
Animal tumor models.
Responsibility: Domenico Ribatti, University of Bari Medical School, Bari, Italy, National Cancer Institute "Giovanni Paolo II", Bari, Italy.

Abstract:

In Vivo Models to Study Angiogenesis provides the latest information and an overview of the most common assays for studying angiogenesis in vivo. Under physiological conditions, angiogenesis is tightly controlled, whereas increased production of angiogenic stimuli and/or reduced production of angiogenic inhibitors leads to abnormal neovascularization, such as occurs in cancer, chronic inflammatory disease, diabetic retinopathy, macular degeneration and cardiovascular disorders. Several genetic and epigenetic mechanisms are involved in the early development of the vascular system. This book presents the latest information from the extensive literature and research available. Evidence is now emerging that blood vessels themselves have the ability to provide instructive regulatory signals to surrounding non-vascular target cells during organ development. Thus, endothelial cell signaling is currently believed to promote fundamental cues for cell fate specification, embryo patterning, organ differentiation and postnatal tissue remodeling. Provides information on the most common assays to study angiogenesis in vivoPresents an ideal reference for those interested in angiogenesis as a normal and vital process in growth and developmentCovers wound healing, the formation of granulation tissue, and the transition of tumors from benign to malignant.

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