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In vivo MR techniques in drug discovery and development

Author: Nicolau Beckmann
Publisher: New York : Taylor & Francis, 2006.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Imaging technologies are receiving much attention in the pharmaceutical industry because of their potential for accelerating drug discovery and development. Magnetic Resonance (MR) Imaging is one of the principal modalities since it allows anatomical, functional, metabolic, and to a certain extent even target-related information to be gathered in vivo at high resolution, favoring the characterization of a disease  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
In vivo MR techniques in drug discovery and development.
New York : Taylor & Francis, 2006
(DLC) 2006040352
(OCoLC)63117055
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Nicolau Beckmann
ISBN: 9781420004526 1420004522
OCLC Number: 143130193
Description: 1 online resource (568 pages) : illustrations (some color)
Contents: Ch 1. The drug discovery and development process : a brief overview / Alex Matter --
ch 2. The drug discovery and development process : opportunities and challenges for MR techniques / Nicolau Beckmann and Markus Rudin --
Editorial comments --
ch 3. Imaging as biomarker for decision-making in drug development / Richard Hargreaves and John A. Wagner --
Editorial comments --
ch 4. Design of contrast agents for molecular imaging in vivo / Silvio Aime, Giovanni B. Giovenzana, Dario Longo, and Enzo Terreno --
Editorial comments --
ch 5. Rapid phenotyping of mice with MRI / X. Josette Chen and R. Mark Henkelman --
Editorial comments --
ch 6. Magnetic resonance imaging and spectroscopy in transgenic mice modeling Alzheimer's disease / Thomas Mueggler --
ch 7. Imaging Alzheimer's disease with MRI / Scott A. Small --
ch 8. MRI and MRS in animal models of focal cerebral ischemia / Markus Rudin, Peter R. Allegrini, and Martin Rausch --
ch 9. MRI in clinical studies of stroke / Eric Juettler, Jochen B. Fiebach, and Peter D. Schellinger --
Editorial comments --
ch 10. Pharmacologic magnetic resonance imaging (phMRI) / Bruce G. Jenkins, Ji-Kyung Choi, Joseph B. Mandeville, and Yin-Ching Iris Chen --
ch 11. Brain fMRI in clinical pharmacological studies / Irene Tracey, Petra Schweinhardt, and Chas Bountra --
ch 12. Imaging inflammatory processes of the brain : multiple sclerosis as an example / Martin Rausch, Iris-Katharina Penner, Cedric Berger, and Markus Rudin --
Editorial comments --
ch 13. Functional and molecular magnetic resonance imaging of preclinical cancer models in drug discovery and development / Zaver M. Bhujwalla, Kristine Glunde, Ellen Ackerstaff, Arvind P. Pathak, Barjor Gimi, Noriko Mori, Venu Raman, and Dmitri Artemov --
ch 14. MR for clinical pharmacological studies in cancer / Geoffrey S. Payne, David J. Collins, Elizabeth M. Charles-Edwards, Mounia Beloueche-Babari, and Martin O. Leach --
ch 15. Molecular imaging in cancer therapies of the future / Chrit Moonen.
Responsibility: edited by Nicolau Beckmann.

Abstract:

Imaging technologies are receiving much attention in the pharmaceutical industry because of their potential for accelerating drug discovery and development. Magnetic Resonance (MR) Imaging is one of the principal modalities since it allows anatomical, functional, metabolic, and to a certain extent even target-related information to be gathered in vivo at high resolution, favoring the characterization of a disease state and the corresponding drug intervention. The non-invasiveness of MR strengthens the link between preclinical and clinical pharmaceutical research, contributing to improve the characterization of compound effects in early stages of the discovery process in order to increase the chances of success in later phases of drug development. Edited by a leading researcher in MR technology, with contributions from foremost experts in academia and the pharmaceutical industry, this title illustrates the use of MR techniques throughout the drug discovery and development process, from target identification and validation to clinical studies. Numerous chapters focus on individual disease areas, including neurological, cardiac, and pulmonary disorders, cancer studies, diabetes, arthritis, solid organ transplantation, and stem cell-based therapies, showing that different imaging solutions are needed for specific organs.

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