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Inflammasome Signaling and Bacterial Infections

Author: Steffen Backert
Publisher: Cham : Springer International Publishing : Imprint : Springer, 2016.
Series: Current topics in microbiology and immunology, 397.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
This volume details our current understanding of the architecture and signaling capabilities of known canonical and non-canonical inflammasome complexes and highlights their action, in particular in response to infection with important bacterial model organisms and the corresponding disease pathologies. The first chapters review new insights into the assembly and structures of inflammasome components and emphasize  Read more...
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Genre/Form: Electronic books
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Steffen Backert
ISBN: 3319411713 9783319411712 9783319411705 3319411705
OCLC Number: 1051169689
Description: 1 online resource (XI, 282 pages 29 illustrations, 28 illustrations in color.).
Contents: Preface; Contents; Abbreviations; 1 General Strategies in Inflammasome Biology; Abstract; 1 Introduction: PRRs, PAMPs, and DAMPs; 2 PRRs as Inflammasome Scaffolds; 3 Inflammasome Activation Mechanisms; 3.1 The NLRP3 Inflammasome; 3.2 The NLRP1 Inflammasome; 3.3 The NLRC4 Inflammasome; 3.4 The AIM2 Inflammasome; 3.5 The Pyrin Inflammasome; 4 Concluding Remarks; Acknowledgments; References; 2 Structural Mechanisms in NLR Inflammasome Assembly and Signaling; Abstract; 1 Introduction; 2 Overviews of NOD-Like Receptors; 3 Auto-Inhibition Mechanism of NLRC4. 4 Mechanism of NAIP-NLRC4 Inflammasome Activation and Assembly5 A Positive Role of the C-Terminal LRR Domain in the Activation of NAIP-NLRC4 Inflammasomes?; 6 Activation of Other NLR Inflammasomes; 7 Insights into the Assembly of ASC-Dependent Inflammasomes; 8 Concluding Remarks; References; 3 Salmonella and the Inflammasome: Battle for Intracellular Dominance; Abstract; 1 Introduction; 1.1 Salmonella; 1.2 Inflammasomes; 2 Salmonella and the Immune Cell Inflammasome; 2.1 Macrophages; 2.1.1 Naip1-6, hNAIP, and Nlrc4; 2.1.2 Nlrp3 and Asc; 2.1.3 Caspase-11. 2.1.4 Other Inflammasomes Involved in Salmonella Detection2.2 Dendritic Cells (DCs); 2.3 Neutrophils; 3 Salmonella and the Intestinal Epithelial Inflammasome; 4 Inflammasome Evasion by Salmonella; 5 Concluding Remarks; References; 4 Activation and Evasion of Inflammasomes by Yersinia; Abstract; 1 Introduction; 1.1 Evolutionary Relationships Among the Pathogenic Yersinia; 1.2 Features of Yersinia-Induced Cell Death; 2 Mechanisms of Yersinia-Induced Cell Death; 2.1 YopJ-Induced Death via the Extrinsic Apoptosis Pathway; 2.2 Inflammasome Sensing of Yersinia Infection and Its Evasion by YopK. 2.3 Evasion of Inflammasome by YopM3 Interactions Between Yersinia and Cell Death Pathways In Vivo; 3.1 Impact of Yersinia-Induced Cell Death on Pathogenesis and Host Defense; 3.2 Activation of Cell Death by Yersinia Virulence Factors In Vivo; 3.3 In Vivo Interactions Between Yersinia and Inflammasome Responses; 4 Concluding Remarks; Acknowledgments; References; 5 The Orchestra and Its Maestro: Shigella's Fine-Tuning of the Inflammasome Platforms; Abstract; 1 Introduction; 2 Epithelial Cells; 3 Macrophages; 4 Neutrophils; 5 Dendritic Cells; 6 Lymphocytes.
Series Title: Current topics in microbiology and immunology, 397.
Responsibility: edited by Steffen Backert.

Abstract:

This volume details our current understanding of the architecture and signaling capabilities of known canonical and non-canonical inflammasome complexes and highlights their action, in particular in  Read more...

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