skip to content
Inflammatory mechanisms in mediating hearing loss Preview this item
ClosePreview this item
Checking...

Inflammatory mechanisms in mediating hearing loss

Author: Vickram Ramkumar; Leonard P Rybak
Publisher: Cham, Switzerland : Springer, [2018] ©2018
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
The primary goal of this project is to describe our current understanding of the oxidant hypothesis of noise and drug-induced hearing loss and show how this process translates into cochlear inflammation. Basic cellular mechanisms underlying the contribution of oxidant stress to hearing loss will be explained and molecular pathways leading to inflammatory processes will be outlined. Several different aspects of the  Read more...
Rating:

(not yet rated) 0 with reviews - Be the first.

Subjects
More like this

Find a copy in the library

&AllPage.SpinnerRetrieving; Finding libraries that hold this item...

Details

Genre/Form: Electronic books
Additional Physical Format: Print version:
Inflammatory mechanisms in mediating hearing loss.
©2018
(OCoLC)1032590949
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Vickram Ramkumar; Leonard P Rybak
ISBN: 9783319925073 3319925075
OCLC Number: 1045796869
Description: 1 online resource
Contents: Intro; Preface; Contents; Contributors; Chapter 1: The Cochlea; 1 Fluid Spaces intheCochlea; 2 Cochlear Duct; 3 Tectorial Membrane; 4 Basilar Membrane; 5 The Lateral Wall oftheCochlea; 6 The Spiral Ligament; 7 Stria Vascularis; Basal Cells; 8 Endocochlear Potential; 9 Organ ofCorti; 10 Mechano-transduction; 11 Hair Cell Synapses; References; Chapter 2: Oxidative Stress andHearing Loss; 1 Introduction; 2 Oxidative Stress; Free Radicals; Oxidative Stress andCytotoxicity; 3 Cochlear Targets ofOxidative Stress; Sensory Epithelium; Lateral Wall; Modiolus. 4 Oxidative Stress inAcquired Hearing LossEnvironmental Exposures; Therapeutic Drugs andAgents; Aging; 5 Interventional Approaches andChallenges; Biomarkers ofOxidative Stress; Otoprotection by Targeting Oxidative Stress; Potential Interference withCell Signaling andDrug Activity; References; Chapter 3: Corticotropin Releasing Factor Signaling intheMammalian Cochlea: AnIntegrative Niche forCochlear Homeostatic Balance Against Noise; 1 Introduction; The Evolution ofHypotheses ConcerningNoise-Induced Hearing Loss. 2 Bounds Related toCurrent Perspectives ofNoise-Induced Damage andFunctional Loss: Cellular Elements ofCochleaTemporary Threshold Shifts (TTS) andAssociated Cellular Elements atRisk forDamage; Previously Described Protective Mechanisms Against NIHL; 3 Elements ofCorticotropin Releasing Factor (Hormone) Signaling Systems, andTheir Expression intheMammalian Inner Ear; A Novel Theory ofLocal Cochlear Signaling Systems Protective AgainstCellular Damage andAssociated NIHL; 4 Inflammatory/Immune Responses intheCochlea Are Driven byAcoustic Over-Exposure. CRF Signaling Is Involved withtheInflammatory Process5 Local (Cochlear) CRF Signaling VersusSystemic HPA Axis: ATale ofTiming, Balance ofMechanistic Actions, andDirect VersusIndirect Signaling; The Indirect CRF Signaling System; The Direct CRF Signaling System, andIts Potential Role inCochlear Function andProtection fromNoise-Induced Damage; 6 Of Glucocorticoids, Clocks, Entrainment, andaPotential Interaction BetweenSystemic andPeripheral CRF Signaling Systems Important forInflammatory Responses intheCochlea; Glucocorticoid Function; Glucocorticoid Receptors. Physiological OscillationsThe Master Clock oftheSuprachiasmatic Nucleus; Peripheral Clocks; 7 A Confluence ofBiological Disciplines That Includes Circadian Biology, Immunology, andCochlear Molecular Neurobiology Converge toSuggest aRole forCochlear CRF Signaling inModulating Inflammatory Responses intheCochlea; A Theory ofCochlear Inflammatory Response toTraumatic Noise Would Include theFollowing Aspects ofSignaling; 8 Conclusions; References; Chapter 4: Cochlear Vascular Pathology andHearing Loss; 1 Introduction; 2 Blood Supply totheLateral Wall.
Responsibility: Vickram Ramkumar, Leonard P. Rybak, editors.

Abstract:

Common forms of preventable hearing loss are drug and noise-induced hearing loss which are believed to be produced by a similar mechanism.  Read more...

Reviews

User-contributed reviews
Retrieving GoodReads reviews...
Retrieving DOGObooks reviews...

Tags

Be the first.

Similar Items

Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Linked Data


Primary Entity

<http://www.worldcat.org/oclc/1045796869> # Inflammatory mechanisms in mediating hearing loss
    a schema:MediaObject, schema:CreativeWork, schema:Book ;
    library:oclcnum "1045796869" ;
    library:placeOfPublication <http://id.loc.gov/vocabulary/countries/sz> ;
    schema:about <http://experiment.worldcat.org/entity/work/data/5354015474#Topic/deafness> ; # Deafness
    schema:about <http://dewey.info/class/617.8/e23/> ;
    schema:about <http://experiment.worldcat.org/entity/work/data/5354015474#Topic/medical_surgery_general> ; # MEDICAL--Surgery--General
    schema:bookFormat schema:EBook ;
    schema:datePublished "2018" ;
    schema:description "The primary goal of this project is to describe our current understanding of the oxidant hypothesis of noise and drug-induced hearing loss and show how this process translates into cochlear inflammation. Basic cellular mechanisms underlying the contribution of oxidant stress to hearing loss will be explained and molecular pathways leading to inflammatory processes will be outlined. Several different aspects of the cochlear inflammatory process will be discussed in detail. These include the sources of inflammatory cells, chemokines, inflammatory cytokines and the roles of cochlear resident immune cells in mediating hearing loss. In addition, evidence for a robust cochlear-based steroid axis which is activated by cochlear stress and serves a protective system. The role of the strial vasculature networks which aid in maintenance of the blood-labyrinth barrier and control the entry of circulating immune cells into the cochlea will be described. Molecular pathways leading to activation of the local inflammatory process will be highlighted and otoprotective treatment options will be discussed. The relevance of certain clinically used anti-inflammatory interventions, such as trans-tympanic steroids and other drugs will also be discussed. Furthermore, we will examine recent patents focusing on the use of anti-inflammatory agents for the treatment of drug and noise-induced hearing loss. It is our hope that this book would provide a better understanding of the interaction of oxidative stress and inflammation in hearing loss. This book should provide basic information to scientists in the field of auditory research and to enlighten clinicians who treat patients with potentially ototoxic drugs."@en ;
    schema:description "Intro; Preface; Contents; Contributors; Chapter 1: The Cochlea; 1 Fluid Spaces intheCochlea; 2 Cochlear Duct; 3 Tectorial Membrane; 4 Basilar Membrane; 5 The Lateral Wall oftheCochlea; 6 The Spiral Ligament; 7 Stria Vascularis; Basal Cells; 8 Endocochlear Potential; 9 Organ ofCorti; 10 Mechano-transduction; 11 Hair Cell Synapses; References; Chapter 2: Oxidative Stress andHearing Loss; 1 Introduction; 2 Oxidative Stress; Free Radicals; Oxidative Stress andCytotoxicity; 3 Cochlear Targets ofOxidative Stress; Sensory Epithelium; Lateral Wall; Modiolus."@en ;
    schema:editor <http://experiment.worldcat.org/entity/work/data/5354015474#Person/ramkumar_vickram> ; # Vickram Ramkumar
    schema:editor <http://experiment.worldcat.org/entity/work/data/5354015474#Person/rybak_leonard_p> ; # Leonard P. Rybak
    schema:exampleOfWork <http://worldcat.org/entity/work/id/5354015474> ;
    schema:genre "Electronic books"@en ;
    schema:inLanguage "en" ;
    schema:isSimilarTo <http://www.worldcat.org/oclc/1032590949> ;
    schema:name "Inflammatory mechanisms in mediating hearing loss"@en ;
    schema:productID "1045796869" ;
    schema:url <http://public.eblib.com/choice/publicfullrecord.aspx?p=5471093> ;
    schema:url <https://doi.org/10.1007/978-3-319-92507-3> ;
    schema:url <https://0-link-springer-com.pugwash.lib.warwick.ac.uk/10.1007/978-3-319-92507-3> ;
    schema:url <https://link.springer.com/10.1007/978-3-319-92507-3> ;
    schema:url <http://www.vlebooks.com/vleweb/product/openreader?id=none&isbn=9783319925073> ;
    schema:url <https://link.springer.com/openurl?genre=book&isbn=978-3-319-92506-6> ;
    schema:url <http://link.springer.com/10.1007/978-3-319-92507-3> ;
    schema:url <http://public.ebookcentral.proquest.com/choice/publicfullrecord.aspx?p=5471093> ;
    schema:url <https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=1855065> ;
    schema:workExample <http://worldcat.org/isbn/9783319925073> ;
    schema:workExample <http://dx.doi.org/10.1007/978-3-319-92507-3> ;
    umbel:isLike <http://bnb.data.bl.uk/id/resource/GBB953119> ;
    wdrs:describedby <http://www.worldcat.org/title/-/oclc/1045796869> ;
    .


Related Entities

<http://experiment.worldcat.org/entity/work/data/5354015474#Person/ramkumar_vickram> # Vickram Ramkumar
    a schema:Person ;
    schema:familyName "Ramkumar" ;
    schema:givenName "Vickram" ;
    schema:name "Vickram Ramkumar" ;
    .

<http://experiment.worldcat.org/entity/work/data/5354015474#Person/rybak_leonard_p> # Leonard P. Rybak
    a schema:Person ;
    schema:familyName "Rybak" ;
    schema:givenName "Leonard P." ;
    schema:name "Leonard P. Rybak" ;
    .

<http://experiment.worldcat.org/entity/work/data/5354015474#Topic/medical_surgery_general> # MEDICAL--Surgery--General
    a schema:Intangible ;
    schema:name "MEDICAL--Surgery--General"@en ;
    .

<http://worldcat.org/isbn/9783319925073>
    a schema:ProductModel ;
    schema:isbn "3319925075" ;
    schema:isbn "9783319925073" ;
    .

<http://www.worldcat.org/oclc/1032590949>
    a schema:CreativeWork ;
    rdfs:label "Inflammatory mechanisms in mediating hearing loss." ;
    schema:description "Print version:" ;
    schema:isSimilarTo <http://www.worldcat.org/oclc/1045796869> ; # Inflammatory mechanisms in mediating hearing loss
    .


Content-negotiable representations

Close Window

Please sign in to WorldCat 

Don't have an account? You can easily create a free account.