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Inflammatory mechanisms in mediating hearing loss

Auteur : Vickram Ramkumar; Leonard P Rybak
Éditeur: Cham, Switzerland : Springer, [2018] ©2018
Édition/format:   Livre électronique : Document : AnglaisVoir toutes les éditions et tous les formats
Résumé:
The primary goal of this project is to describe our current understanding of the oxidant hypothesis of noise and drug-induced hearing loss and show how this process translates into cochlear inflammation. Basic cellular mechanisms underlying the contribution of oxidant stress to hearing loss will be explained and molecular pathways leading to inflammatory processes will be outlined. Several different aspects of the  Lire la suite...
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Genre/forme: Electronic books
Format – détails additionnels: Print version:
Inflammatory mechanisms in mediating hearing loss.
©2018
(OCoLC)1032590949
Type d’ouvrage: Document, Ressource Internet
Type de document: Ressource Internet, Fichier d'ordinateur
Tous les auteurs / collaborateurs: Vickram Ramkumar; Leonard P Rybak
ISBN: 9783319925073 3319925075
Numéro OCLC: 1045796869
Description: 1 online resource
Contenu: Intro; Preface; Contents; Contributors; Chapter 1: The Cochlea; 1 Fluid Spaces intheCochlea; 2 Cochlear Duct; 3 Tectorial Membrane; 4 Basilar Membrane; 5 The Lateral Wall oftheCochlea; 6 The Spiral Ligament; 7 Stria Vascularis; Basal Cells; 8 Endocochlear Potential; 9 Organ ofCorti; 10 Mechano-transduction; 11 Hair Cell Synapses; References; Chapter 2: Oxidative Stress andHearing Loss; 1 Introduction; 2 Oxidative Stress; Free Radicals; Oxidative Stress andCytotoxicity; 3 Cochlear Targets ofOxidative Stress; Sensory Epithelium; Lateral Wall; Modiolus. 4 Oxidative Stress inAcquired Hearing LossEnvironmental Exposures; Therapeutic Drugs andAgents; Aging; 5 Interventional Approaches andChallenges; Biomarkers ofOxidative Stress; Otoprotection by Targeting Oxidative Stress; Potential Interference withCell Signaling andDrug Activity; References; Chapter 3: Corticotropin Releasing Factor Signaling intheMammalian Cochlea: AnIntegrative Niche forCochlear Homeostatic Balance Against Noise; 1 Introduction; The Evolution ofHypotheses ConcerningNoise-Induced Hearing Loss. 2 Bounds Related toCurrent Perspectives ofNoise-Induced Damage andFunctional Loss: Cellular Elements ofCochleaTemporary Threshold Shifts (TTS) andAssociated Cellular Elements atRisk forDamage; Previously Described Protective Mechanisms Against NIHL; 3 Elements ofCorticotropin Releasing Factor (Hormone) Signaling Systems, andTheir Expression intheMammalian Inner Ear; A Novel Theory ofLocal Cochlear Signaling Systems Protective AgainstCellular Damage andAssociated NIHL; 4 Inflammatory/Immune Responses intheCochlea Are Driven byAcoustic Over-Exposure. CRF Signaling Is Involved withtheInflammatory Process5 Local (Cochlear) CRF Signaling VersusSystemic HPA Axis: ATale ofTiming, Balance ofMechanistic Actions, andDirect VersusIndirect Signaling; The Indirect CRF Signaling System; The Direct CRF Signaling System, andIts Potential Role inCochlear Function andProtection fromNoise-Induced Damage; 6 Of Glucocorticoids, Clocks, Entrainment, andaPotential Interaction BetweenSystemic andPeripheral CRF Signaling Systems Important forInflammatory Responses intheCochlea; Glucocorticoid Function; Glucocorticoid Receptors. Physiological OscillationsThe Master Clock oftheSuprachiasmatic Nucleus; Peripheral Clocks; 7 A Confluence ofBiological Disciplines That Includes Circadian Biology, Immunology, andCochlear Molecular Neurobiology Converge toSuggest aRole forCochlear CRF Signaling inModulating Inflammatory Responses intheCochlea; A Theory ofCochlear Inflammatory Response toTraumatic Noise Would Include theFollowing Aspects ofSignaling; 8 Conclusions; References; Chapter 4: Cochlear Vascular Pathology andHearing Loss; 1 Introduction; 2 Blood Supply totheLateral Wall.
Responsabilité: Vickram Ramkumar, Leonard P. Rybak, editors.

Résumé:

Common forms of preventable hearing loss are drug and noise-induced hearing loss which are believed to be produced by a similar mechanism.  Lire la suite...

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