Inhibitors of molecular chaperones as therapeutic agents (Book, 2014) []
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Inhibitors of molecular chaperones as therapeutic agents

Inhibitors of molecular chaperones as therapeutic agents

Author: Zhenhai Gao; Timothy D Machajewski
Publisher: Cambridge : Royal Society of Chemistry, 2014.
Series: RSC drug discovery series, vol. 37.
Edition/Format:   Print book : EnglishView all editions and formats

This book aims to provide a comprehensive examination of the field of molecular chaperone inhibition and its application to pharmaceutical research.

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Document Type: Book
All Authors / Contributors: Zhenhai Gao; Timothy D Machajewski
ISBN: 9781849736664 1849736669
OCLC Number: 1123905766
Description: xvi, 425 p. : il. ; 24 cm.
Contents: Section I Structure and Function: Conformational Dynamics, Structure and Functional Interactions of Hsp90 Chaperones; Structural Basis of Hsp90 Function; Structure and Function of Hsp70 - TBD; Exploiting the Dependency of Cancer Cells on Molecular Chaperones; Section II Small Molecule Inhibitors; Discovery of BIIB028; Discovery of STA-9090; Discovery of Serenex Hsp90 Inhibitor; Discovery of NVP-AUY922; Discovery of NVP-HSP990; Inhibitors of Hsp90 C-Terminal Domain; Hsp70 Inhibitors; Section III Clinical Perspectives; Clinical Development of Hsp90 Inhibitors as Anti-Cancer Agents; Hsp90 as a Potential Anti-Malarial Agent; Biomarker Development and Indication Selection; Other Disease Indications
Series Title: RSC drug discovery series, vol. 37.
Responsibility: edited by Timothy D. Machajewski and Zhenhai Gao.


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"...this 422- page volume adds greatly to the discussion by reporting many of the more recent advances in targeting Hsp90, whilst including an elegant overview of the advances in Hsp70 research, an Read more...

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