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Inhibitors of molecular chaperones as therapeutic agents

Author: Zhenhai Gao; Timothy D Machajewski
Publisher: Cambridge : Royal Society of Chemistry, 2014.
Series: RSC drug discovery series, vol. 37.
Edition/Format:   Print book : EnglishView all editions and formats
Summary:

This book aims to provide a comprehensive examination of the field of molecular chaperone inhibition and its application to pharmaceutical research.

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Document Type: Book
All Authors / Contributors: Zhenhai Gao; Timothy D Machajewski
ISBN: 9781849736664 1849736669
OCLC Number: 1123905766
Description: xvi, 425 p. : il. ; 24 cm.
Contents: Section I Structure and Function: Conformational Dynamics, Structure and Functional Interactions of Hsp90 Chaperones; Structural Basis of Hsp90 Function; Structure and Function of Hsp70 - TBD; Exploiting the Dependency of Cancer Cells on Molecular Chaperones; Section II Small Molecule Inhibitors; Discovery of BIIB028; Discovery of STA-9090; Discovery of Serenex Hsp90 Inhibitor; Discovery of NVP-AUY922; Discovery of NVP-HSP990; Inhibitors of Hsp90 C-Terminal Domain; Hsp70 Inhibitors; Section III Clinical Perspectives; Clinical Development of Hsp90 Inhibitors as Anti-Cancer Agents; Hsp90 as a Potential Anti-Malarial Agent; Biomarker Development and Indication Selection; Other Disease Indications
Series Title: RSC drug discovery series, vol. 37.
Responsibility: edited by Timothy D. Machajewski and Zhenhai Gao.

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Since the discovery in the mid-1990s that geldanamycin, a benzo- quinone ansamcin, acts as an inhibitor of heat shock protein 90 (Hsp90), research in this area has boomed. Whilst several topics Read more...

 
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