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Document Type: | Book |
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All Authors / Contributors: |
Zhenhai Gao; Timothy D Machajewski |
ISBN: | 9781849736664 1849736669 |
OCLC Number: | 1123905766 |
Description: | xvi, 425 p. : il. ; 24 cm. |
Contents: | Section I Structure and Function: Conformational Dynamics, Structure and Functional Interactions of Hsp90 Chaperones; Structural Basis of Hsp90 Function; Structure and Function of Hsp70 - TBD; Exploiting the Dependency of Cancer Cells on Molecular Chaperones; Section II Small Molecule Inhibitors; Discovery of BIIB028; Discovery of STA-9090; Discovery of Serenex Hsp90 Inhibitor; Discovery of NVP-AUY922; Discovery of NVP-HSP990; Inhibitors of Hsp90 C-Terminal Domain; Hsp70 Inhibitors; Section III Clinical Perspectives; Clinical Development of Hsp90 Inhibitors as Anti-Cancer Agents; Hsp90 as a Potential Anti-Malarial Agent; Biomarker Development and Indication Selection; Other Disease Indications |
Series Title: | RSC drug discovery series, vol. 37. |
Responsibility: | edited by Timothy D. Machajewski and Zhenhai Gao. |
Reviews
Publisher Synopsis
"...this 422- page volume adds greatly to the discussion by reporting many of the more recent advances in targeting Hsp90, whilst including an elegant overview of the advances in Hsp70 research, an area that has received considerably less re- search attention until more recently. The editors have assembled work from a variety of leading experts in the molecular chaperone field...""...the authors have produced an outstanding overview of the subject that will be an extremely useful account for a wide variety of scientists...""...the authors present an excellent and thought-provoking outlook on the future of the subject""Overall the book is very well written, should appeal to academic and industrial medicinal chemists and to those in closely related fields. The text will prove particularly useful to those of a more biological persuasion or those looking to study Hsp70, and would be an excellent addition to any science or medical-based library." -- Dr. Russell R. A. Kitson, University of Nottingham * Chemmedchem review in March 2015 issue * Read more...

