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Inhibitors of molecular chaperones as therapeutic agents

ผู้แต่ง: Timothy D Machajewski; Zhenhai Gao; Royal Society of Chemistry (Great Britain),
สำนักพิมพ์: Cambridge : RSC Publishing, [2014]
ชุด: RSC drug discovery series, 37.
ครั้งที่พิมพ์/รูปแบบ:   พิมพ์หนังสือ : ภาษาอังกฤษดูครั้งที่พิมพ์และรูปแบบ
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This book aims to provide a comprehensive examination of the field of molecular chaperone inhibition and its application to pharmaceutical research. With several small molecule inhibitors in oncology clinical development, there is clearly intense interest in the chaperones as a molecular target. Filling a significant gap in the market by providing a detailed comparison of discovery programs across the industry, this  อ่านมากขึ้น…
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ผู้แต่งทั้งหมด : ผู้แต่งร่วม Timothy D Machajewski; Zhenhai Gao; Royal Society of Chemistry (Great Britain),
ISBN: 9781849736664 1849736669
OCLC Number: 866582685
คำอธิบาย: xvi, 425 pages : illustrations.
สารบัญ: Section I Structure and Function: Conformational Dynamics, Structure and Functional Interactions of Hsp90 Chaperones; Structural Basis of Hsp90 Function; Structure and Function of Hsp70 - TBD; Exploiting the Dependency of Cancer Cells on Molecular Chaperones; Section II Small Molecule Inhibitors; Discovery of BIIB028; Discovery of STA-9090; Discovery of Serenex Hsp90 Inhibitor; Discovery of NVP-AUY922; Discovery of NVP-HSP990; Inhibitors of Hsp90 C-Terminal Domain; Hsp70 Inhibitors; Section III Clinical Perspectives; Clinical Development of Hsp90 Inhibitors as Anti-Cancer Agents; Hsp90 as a Potential Anti-Malarial Agent; Biomarker Development and Indication Selection; Other Disease Indications
ชื่อชุด: RSC drug discovery series, 37.
ความรับผิดชอบ: edited by Timothy Machajewski and Zhenhai Gao.

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This book aims to provide a comprehensive examination of the field of molecular chaperone inhibition and its application to pharmaceutical research.  อ่านมากขึ้น…

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"...this 422- page volume adds greatly to the discussion by reporting many of the more recent advances in targeting Hsp90, whilst including an elegant overview of the advances in Hsp70 research, an อ่านมากขึ้น…

 
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