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Integrating the Neurobiology of Schizophrenia

Author: Anissa Abi-Dargham; Olivier Guillin
Publisher: Amsterdam ; Boston : Elsevier, 2007.
Series: International review of neurobiology, v. 78.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
A thorough overview of all neurotransmitters involved in schizophrenia.
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Integrating the neurobiology of schizophrenia.
Amsterdam ; Boston : Elsevier, ©2007
(OCoLC)122378591
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Anissa Abi-Dargham; Olivier Guillin
ISBN: 9780080475080 0080475086 0123737370 9780123737373
OCLC Number: 137276169
Language Note: Text in English.
Description: 1 online resource (xvi, 459 pages) : illustrations (some color).
Contents: Cover --
Copyright Page --
Contents --
Contributors --
Preface --
References --
Chapter 1: Neurobiology of Dopamine in Schizophrenia --
I. Introduction --
II. Dopaminergic System in the Brain --
A. Dopaminergic Projections --
B. Dopaminergic Receptors --
III. Evidence Supporting Alterations of DA Systems in Schizophrenia --
A. Pharmacological Evidence --
B. Postmortem Studies --
C. Imaging Studies --
IV. Conclusions --
References --
Chapter 2: The Dopamine System and the Pathophysiology of Schizophrenia: A Basic Science Perspective --
I. Introduction --
II. Neuroanatomy of DA Systems --
III. DA Neuron Activity and Release --
IV. Cellular Actions of DA --
V. Roles of DA on Cognitive and Affective Functions --
VI. Development and Maturation of the DA System --
VII. DA Deficits in Schizophrenia --
VIII. Conclusions --
References --
Chapter 3: Glutamate and Schizophrenia: Phencyclidine, N-Methyl-D-Aspartate Receptors, and Dopamine-Glutamate Interactions --
I. Introduction --
II. Glutamatergic Physiology --
A. Glutamate-Dopamine Comparisons --
B. Glutamate Receptors --
C. NMDA Receptors --
D. AMPA/Kainate Receptors --
E. Metabotropic Receptors --
III. Glutamatergic Models of Schizophrenia --
A. Symptom Patterns Following NMDA Antagonist Administration --
B. Cognitive Deficits Following NMDA Antagonist Treatment --
C. In Vivo Findings in Schizophrenia Based on Dopamine Receptor Occupancy --
D. Postmortem Findings --
IV. Clinical Studies with NMDA Agonists --
A. NMDA Receptor Glycine-Site Agonists --
B. Glycine Transport Inhibitors --
C. Other Ionotropic Targets --
D. Metabotropic Receptors --
E. Group I Receptors --
F. Group II Metabotropic Agonists --
V. Potential Causes of Glutamatergic Dysfunction in Schizophrenia --
A. Dopamine-Glutamate Interactions --
B. Linkage-Association Studies in Schizophrenia --
C. Environmental and Neurochemical Factors --
VI. Future Research and Treatment Implications --
Acknowledgments --
References --
Chapter 4: Deciphering the Disease Process of Schizophrenia: the. Contribution of Cortical Gaba Neurons --
I. Working Memory Impairments: A Core Feature of Schizophrenia --
II. Working Memory Impairments and Altered GABA Neurotransmission in the DLPFC --
III. Potential Pathogenetic Mechanisms for Cell Type-Specific Alterations in GABA Neurons --
A. Reduced Excitatory Drive via NMDA Receptors --
B. Reduced Neurotrophin Signaling --
IV. Connecting Alterations in PV-Positive Neurons to Working Memory Impairments: Decreased Gamma Band Synchrony in Schizophrenia --
V. Treatment Implications --
Acknowledgments --
References --
Chapter 5: Alterations of Serotonin Transmission in Schizophrenia --
I. Introduction --
II. Alteration of 5-HT Receptors in Schizophrenia --
A. 5-HT Transporters --
B. 5-HT1A Receptors --
C. 5-HT2 Receptors --
D. Other Receptors --
III. Pharmacological Manipulation of 5-HT Transmission in Schizophrenia --
A. 5-HT Precursors --
B. 5-HT Depleting Agents --
C. 5-HT2A Agonism: LSD and "Model.
Series Title: International review of neurobiology, v. 78.
Responsibility: edited by Anissa Abi-Dargham, Olivier Guillin.

Abstract:

Examines the role that dopamine plays in schizophrenia, examining its role in not only the symptoms of the disease but also in its treatment. This work also reviews various neurotransmitters that  Read more...

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