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Genre/Form: | Thèses et écrits académiques |
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Material Type: | Document, Thesis/dissertation |
Document Type: | Computer File |
All Authors / Contributors: |
Fanny Lebossé; Fabien Zoulim; Stanislas Pol; Jean-Michel Pawlotsky; Christine Neuveut, biologiste).; Massimo Levrero; Vincent Leroy, meÌdecin).; Université Claude Bernard (Lyon).; École Doctorale de Biologie Moléculaire Intégrative et Cellulaire (Lyon).; Centre de Recherche en Cancérologie de Lyon. |
OCLC Number: | 946908238 |
Notes: | Titre provenant de l'écran-titre. |
Description: | 1 online resource |
Responsibility: | Fanny Lebossé ; sous la direction de Fabien Zoulim. |
Abstract:
Chronic HBV infections (CHB) are difficult to treat diseases because of viral persistence. It's explained by the particular replication of Hepatitis B Virus (HBV) and its interplays with host immunity. CHB is characterized by different stages, which reflect a balance between viral replication and immune response. However, our knowledge regarding the natural history of CHB is insufficient to allow us to predict patients' prognosis. Further clinical studies are needed to improve our understanding of interplays between HBV replication and host immunity. The first study is a retrospective one about interplays between serological and intrahepatic viral markers and intrahepatic innate immunity genes expression. Immunity genes seem to be down-regulated during CHB in comparison to healthy controls, without impact of the level of viral replication. HBsAg levels in blood may reflect the intrahepatic innate immune response and especially the type I IFN response for HBeAg negative patients. The second part is a prospective study which shows any relevance of adding PEG-IFN to HIV/HBV co-infected responders to NUCS therapy patients. The results highlight the potential interest of baseline HBsAg level to predict PEG-IFN response (low HBsAg levels being more favorable). Finally, these results highlight the role of interplays between HBV replication and innate immune response during the natural history of CHB. They may be interesting in the context of the development of new antiviral strategies.
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Related Subjects:(6)
- Virus de l'hépatite B.
- Résistance aux maladies.
- Antigènes viraux.
- HBV
- Réponse immunitaire innée
- AgHBs