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Intermediate filaments : a review

Author: Peter Traub
Publisher: Berlin ; New York : Springer-Verlag, ©1985.
Edition/Format:   Print book : EnglishView all editions and formats
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Additional Physical Format: Online version:
Traub, Peter, 1935-
Intermediate filaments.
Berlin ; New York : Springer-Verlag, ©1985
(OCoLC)560931008
Online version:
Traub, Peter, 1935-
Intermediate filaments.
Berlin ; New York : Springer-Verlag, ©1985
(OCoLC)608885703
Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Peter Traub
ISBN: 0387151052 9780387151052 3540151052 9783540151050
OCLC Number: 11756054
Description: ix, 266 pages ; 25 cm
Contents: 1 Introduction.- 2 Distribution of Intermediate Filaments.- 2.1 Intercellular Distribution of Intermediate Filaments.- 2.1.1 Intermediate Filaments in Early Differentiation.- 2.1.1.1 Murine Embryogenesis.- 2.1.1.2 Chick Embryogenesis.- 2.1.1.3 Teratocarcinoma Cells.- 2.1.1.4 Epithelial Cell Differentiation.- 2.1.1.5 Myogenesis.- 2.1.2 Intermediate Filament Proteins in Differentiated Tissues.- 2.1.2.1 Cytokeratins.- 2.1.2.2 Desmin.- 2.1.2.3 Vimentin.- 2.1.2.4 Glial Fibrillary Acidic Protein (GFAP).- 2.1.2.5 Neurofilament Proteins.- 2.1.3 Intermediate Filaments in Disease.- 2.1.3.1 Tumor Diagnosis.- 2.1.3.2 Mallory Bodies.- 2.1.3.3 Neuropathies.- 2.1.3.4 Autoantibodies.- 2.1.4 Intermediate Filament Proteins in Evolution.- 2.1.5 Potential Intermediate Filament Subunit Proteins.- 2.1.5.1 Synemin.- 2.1.5.2 Paranemin.- 2.1.5.3 66 kDa Protein.- 2.1.5.4 68 kDa Protein.- 2.1.5.5 95 kDa Protein.- 2.1.5.6 50 kDa Neurofilament Proteins.- 2.1.5.7 60 to 70 kDa Intermediate Filament-Associated Proteins.- 2.1.6 Intermediate Filament Proteins in Cell Culture.- 2.1.6.1 Vimentin.- 2.1.6.2 Desmin.- 2.1.6.3 Glial Fibrillary Acidic Protein.- 2.1.6.4 Neurofilament Proteins.- 2.1.6.5 Cytokeratins.- 2.2 Intracellular Distribution of Intermediate Filaments and Their Interaction with Organelles and Proteins.- 2.2.1 Microtubules.- 2.2.2 Microfilaments.- 2.2.3 Mitochondria.- 2.2.4 Plasma Membrane.- 2.2.5 Nucleus.- 2.2.6 Endoplasmic Reticulum and Golgi Apparatus.- 2.2.7 Other Cellular Organelles.- 2.2.8 Proteins and Enzymatic Activities.- 2.2.8.1 Filaggrin.- 2.2.8.2 Microtubule-Associated Proteins (MAPs).- 2.2.8.3 Enzymes and Other Proteins.- 2.2.9 Intermediate Filaments in Muscle.- 2.3 Intracellular Reorganization of Intermediate Filament Systems.- 2.3.1 Mitosis.- 2.3.2 Microinjection of Antibodies.- 2.3.3 Virus Infection.- 2.3.4 Receptor-Mediated Endocytosis.- 2.3.5 Drugs, Toxins, and Growth Factors.- 2.3.6 Physical Manipulations.- 2.3.7 Cell Spreading.- 2.4 In Vivo Assembly of Intermediate Filaments.- 2.5 Isolation and Subunit Composition of Intermediate Filaments.- 3 In Vitro Assembly and Structure of Intermediate Filaments.- 3.1 In Vitro Reconstitution.- 3.1.1 Cytokeratin Filaments.- 3.1.2 Vimentin and Desmin Filaments.- 3.1.3 Glial Filaments.- 3.1.4 Neurofilaments.- 3.2 Helical Substructure.- 3.3 Architecture of Protofilaments.- 3.3.1 Three-Strand Model of Protofilaments.- 3.3.2 Four-Strand Model of Protofilaments.- 3.4 Function of the N-Terminal Polypeptide.- 3.5 Structure of Intermediate Filament Subunit Proteins.- 3.5.1 Peptide Mapping.- 3.5.2 Amino Acid Composition.- 3.5.3 Amino Acid Sequence.- 3.5.3.1 Desmin.- 3.5.3.2 Vimentin.- 3.5.3.3 Glial Fibrillary Acidic Protein.- 3.5.3.4 Neurofilament Proteins.- 3.5.3.5 Cytokeratins.- 3.5.3.6 Wool ?-Keratins.- 3.5.3.7 General Remarks on the Structure of Intermediate Filament Proteins.- 4 Synthesis of Intermediate Filament Proteins in Vitro.- 5 Posttranslational Modification of Intermediate Filament Proteins.- 5.1 Phosphorylation of Intermediate Filament Proteins.- 5.1.1 Neurofilament Proteins.- 5.1.2 Desmin and Vimentin.- 5.1.3 Cytokeratins.- 5.1.4 Phosphorylation Sites.- 5.1.5 Functional Role of Intermediate Filament Protein Phosphorylation.- 5.2 Ca2+-Dependent Proteolysis of Intermediate Filament Proteins.- 5.2.1 Neurofilament Proteins.- 5.2.2 Glial Fibrillary Acidic Protein.- 5.2.3 Vimentin and Desmin.- 5.2.4 Cytokeratins.- 5.2.5 Relatedness of Different Ca2+-Activated Proteinases.- 5.2.6 Putative Site of Action of Ca2+-Activated Proteinases.- 5.3 Modification of Intermediate Filament Proteins by Transglutaminases.- 5.3.1 Neurofibrillary Tangles.- 5.3.2 Transglutaminases in Nonneural Cells.- 5.3.3 Properties and Putative Site of Action of Transglutaminases.- 5.3.4 Are Transglutaminases and Ca2+-Activated Proteinases Jointly Involved in Receptor-Mediated Endocytosis?.- 6 Cellular Function(s) of Intermediate Filaments and Their Subunit Proteins.- 6.1 Interaction in Vitro of Intermediate Filament Proteins with Nucleic Acids and Histones.- 6.2 Are Intermediate Filament Proteins Involved in Information Transfer?.- 6.3 Possible Function of Intermediate Filament Proteins in Nerve Cells.- 6.4 Possible Function of Intermediate Filament Proteins in Muscle Cells.- 7 Summary and Concluding Remarks.- References.
Responsibility: Peter Traub.

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