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Kinase drug discovery

Author: Richard A Ward; Frederick Goldberg
Publisher: Cambridge : Royal Society of Chemistry, 2018.
Series: RSC drug discovery series, v. 67.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:

This book is a forward-looking analysis of a number of key areas for kinase inhibition in the coming years.

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Genre/Form: Electronic books
Additional Physical Format: Print version:
Kinase drug discovery.
Cambridge : Royal Society of Chemistry, 2018
(OCoLC)1064580107
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Richard A Ward; Frederick Goldberg
ISBN: 9781788013093 1788013093 9781788015639 1788015630
OCLC Number: 1076272026
Description: 1 online resource
Contents: Introduction to Kinase Drug Discovery --
Modern Approaches; New Screening Approaches for Kinases; The Screening and Design of Allosteric Kinase Inhibitors; Covalent Inhibition of Kinases; Small Molecule Macrocyclic Kinase Inhibitors; The Design of Brain Penetrant Kinase Inhibitors; Cutting Edge Approaches to Structure-based Computational Modelling of Kinases; The Properties of Kinase Inhibitors; Assessment and Optimisation of Kinases Inhibitor Selectivity to Achieve Candidates with an Appropriate Safety Profile; Drugging the Kinome; The Importance of Kinase Mutations in Cancer Drug Discovery; Kinase Inhibition for Immuno-oncology; A Structural Perspective of the Pseudokinome: Defining the Targetable Space; The Future of Kinase Therapeutics; Subject Index
Series Title: RSC drug discovery series, v. 67.
Responsibility: edited by Richard A. Ward, Frederick W. Goldberg.

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