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Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates

Author: Al Postigo
Publisher: Amsterdam, Netherlands : Elsevier, [2019]
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates reviews how the use of these techniques on compounds with already known and relevant biological activity can provide new pharmaceutical leads with improved medicinal properties. The fluorination strategies discussed take into account both conventional and novel reagents, including nucleophilic, electrophilic, those of a radical  Read more...
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Genre/Form: Electronic books
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Al Postigo
ISBN: 9780128130391 0128130393
OCLC Number: 1052566523
Description: 1 online resource : illustrations
Contents: 1. Introduction and Highlights 2. 18F radiolabeling of bioactive compounds 3. Electrophilic and oxidative fluorination of aromatic compounds 4. Enantioselective fluorination 5. Visible-Light-Mediated C-F bond Activation 6. Photocatalytic fluorination reactions 7. Fluorination of allylic positions towards the synthesis of fluorinated bioactive compounds 8. Difluoromethylation of Bioactive Compounds 9. Fluorination of Bioactive Compounds by Electron Transfer Reactions 10. Fluorine-Containing Pharmaceuticals and the Phenomenon of Self-Disproportionation of Enantiomers (SDE)
Responsibility: Al Postigo.

Abstract:

Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates reviews how the use of these techniques on compounds with already known and relevant biological activity can provide new pharmaceutical leads with improved medicinal properties. The fluorination strategies discussed take into account both conventional and novel reagents, including nucleophilic, electrophilic, those of a radical nature, and diverse families of organic compounds, such as (hetero) aromatic rings and aliphatic substrates. Drawing on the authors' expert knowledge, this book provides researchers with a broad set of applicable methods to use in their work.

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