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Leishmania : after the genome

Author: Peter John Myler; Nicolas Fasel
Publisher: Norfolk, UK : Caister Academic, 2008.
Edition/Format:   Print book : EnglishView all editions and formats
Summary:
Leishmania is a vector-prone pathogenic parasite found in 88 countries worldwide and is the causative agent of leishmaniasis. The different Leishmania species infect macrophages and dendritic cells of the host immune system, causing symptoms that include disfiguring cutaneous and mucocutaneous lesions, widespread destruction of mucous membranes and visceral disease affecting the haemopoietic organs. The recent  Read more...
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Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Peter John Myler; Nicolas Fasel
ISBN: 9781904455288 190445528X
OCLC Number: 171110678
Description: xiv, 306 pages, 1 pages of plates : illustrations ; 26 cm
Contents: 1. Leishmaniasis: Epidemiological Trends and Diagnosis / Anupam Jhingaran, Mitali Chatterjee and Rentala Madhubala --
2. Genome Structure and Content / Peter J. Myler --
3. Regulation of Gene Expression in Leishmania Throughout a Complex Digenetic Life Cycle / Barbara Papadopoulou, Michaela Muller, Annie Rochette, Francois McNicoll, Carole Dumas and Conan Chow --
4. The Leishmania Proteome / Nicolas Fasel, Nathalie Acestor, Amal El Fadili-Kundig, Iveth Gonzalez and Slavica Masina --
5. Analysis of the Leishmania Metabolome / Malcolm J. McConville, David P. De Souza, Eleanor C. Saunders, James Pyke, Thomas Naderer, Miriam A. Ellis, Fleur M. Sernee, Julie E. Ralton and Vladimir A. Likic --
6. Physiological and Biochemical Aspects of Leishmania Development / Dan Zilberstein --
7. The Metabolic Repertoire of Leishmania and Implications for Drug Discovery / Fred R. Opperdoes and Paul A. M. Michels --
8. Drug Resistance in Leishmania / Marc Ouellette, Jolyne Drummelsmith, Philippe Leprohon, Karima El Fadili, Aude Foucher, Baptiste Vergnes and Danielle Legare --
9. Leishmania Surface Proteins / Emanuela Handman, Anthony T. Papenfuss, Terence P. Speed and James W. Goding --
10. The Biology of Leishmania-Sandfly Interactions / David Sacks, Phillip Lawyer and Shaden Kamhawi --
11. Interactions Between Leishmania and the Host Macrophage / Martin Olivier and David J. Gregory --
12. Host Responses to infections with Leishmania / Fabienne Tacchini-Cortier and Pascal Launois --
13. Impact of the Leishmania Genome on Vaccine Development / Jenefer M. Blackwell, Diane McMahon-Pratt and Mary E. Wilson.
Responsibility: [edited by] Peter J. Myler and Nicolas Fasel.

Abstract:

Leishmania is a vector-prone pathogenic parasite found in 88 countries worldwide and is the causative agent of leishmaniasis. The different Leishmania species infect macrophages and dendritic cells of the host immune system, causing symptoms that include disfiguring cutaneous and mucocutaneous lesions, widespread destruction of mucous membranes and visceral disease affecting the haemopoietic organs. The recent publication of the comlete gennome sequences of three different Leishmania species provides new insights into this leading pathogen. In this book, experts critically review the most important aspects of Leishmania research. Chapters are written from a molecular and genomic perspective and discuss in depth Leishmania-specific aspects of trypanosomatid biology and pathology. Topics include diagnosis and epidemiology, genome structure and content, regulation of gene expression, the Leishmania proteome, the Leishmania metabolome, Leishmania differentiation, interaction with the sand fly vector, drug discovery, drug resistance, and much more.

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