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Leukemia stem cells in hematologic malignancies

Author: Haojian Zhang; Shaoguang Li
Publisher: Singapore : Springer, [2019] ©2019
Series: Advances in experimental medicine and biology, v. 1143.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
This book introduces readers to the biology of leukemia stem cells (LSCs) and emphasizes the necessity and importance of targeting LSCs in the treatment of hematopoietic malignancies. It addresses the role of leukemia stem cells in different leukemia diseases and molecular signatures, as well as the metabolic and epigenetic regulation of leukemia stem cell function. With regard to solid tumors, a significant number  Read more...
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Details

Genre/Form: Electronic books
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Haojian Zhang; Shaoguang Li
ISBN: 9789811373428 9811373426
OCLC Number: 1114288903
Description: 1 online resource : illustrations (some color)
Contents: Role of leukemia stem cells in pathogenesis of hematologic malignancies --
Leukemia stem cells in chronic myeloid leukemia --
Leukmeia stem cells in MLL-rearranged acute myeloid leukemia --
Interaction between leukmeia stem cells and bone marrow environment --
Molecular signatures of leukemia stem cells --
Metabolic regulation of leukemia stem cell function --
Epigenetic regulation of leukmeia stem cell function --
DNA instability and leukemia stem cell function --
Tumor suppressor genes in leukemia stem cells --
Targeting leukemia stem cells --
Leukemia stem cells and drug resistance --
Hypoxia and leukemia.
Series Title: Advances in experimental medicine and biology, v. 1143.
Responsibility: Haojian Zhang, Shaoguang Li, editors.

Abstract:

This book introduces readers to the biology of leukemia stem cells (LSCs) and emphasizes the necessity and importance of targeting LSCs in the treatment of hematopoietic malignancies.  Read more...

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