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Long-term shifts in adolescent nicotine reward following early methylphenidate exposure in male and female rats

Author: Arturo D Garcia
Publisher: [Long Beach, California] : California State University, Long Beach, 2013.
Dissertation: M.S. California State University, Long Beach 2013
Series: California State University, Long Beach.; Master's thesis collection, Dept. of Health Care Administration.
Edition/Format:   Thesis/dissertation : Thesis/dissertation   Computer File : English
Summary:
Abstract: Methylphenidate is vastly prescribed in children, and few studies have examined the functional consequences of such early exposure on later susceptibility to nicotine reward. Thus, the present thesis used an animal model to examine the effects of early methylphenidate exposure on nicotine-induced conditioned place preference (CPP), a validated animal model of drug reward. Rats were given methylphenidate  Read more...
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Details

Genre/Form: Academic theses
Material Type: Thesis/dissertation, Internet resource
Document Type: Book, Computer File, Internet Resource
All Authors / Contributors: Arturo D Garcia
ISBN: 9781303765902 130376590X
OCLC Number: 1020289520
Description: viii, 82 leaves : illustrations, charts
Series Title: California State University, Long Beach.; Master's thesis collection, Dept. of Health Care Administration.
Responsibility: by Arturo D. Garcia.

Abstract:

Abstract: Methylphenidate is vastly prescribed in children, and few studies have examined the functional consequences of such early exposure on later susceptibility to nicotine reward. Thus, the present thesis used an animal model to examine the effects of early methylphenidate exposure on nicotine-induced conditioned place preference (CPP), a validated animal model of drug reward. Rats were given methylphenidate (0,2,4 mg/kg) during postnatal days 11-20 and then assessed for nicotine-induced CPP during adolescence. Results indicated that MPH exposure enhanced sensitivity to nicotine; however, the nature of this enhancement differed by age and sex. Specifically, early adolescent male rats showed increased sensitivity to nicotine compared to controls, while late adolescent male rats showed a decrease in the aversive effects of nicotine. In contrast, only early adolescent female rats showed an enhanced sensitivity to nicotine. This thesis adds to recent evidence showing that early methylphenidate exposure alters the rewarding value of drugs.

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