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Macromolecular crystallography : conventional and high-throughput methods

Author: Mark R Sanderson; Jane Skelly
Publisher: Oxford, UK ; New York : Oxford University Press, 2007.
Series: Oxford biosciences
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
This volume deals with high-throughput methods from cloning and crystallisation to refinement and modelling. It includes contributions from internationally recognized leaders offering chapters on conventional and high-throughput methods.
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Macromolecular crystallography.
Oxford, UK ; New York : Oxford University Press, 2007
(OCoLC)76797955
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Mark R Sanderson; Jane Skelly
ISBN: 9780191523427 0191523429
OCLC Number: 190864216
Language Note: English.
Notes: "Oxford biosciences."
Description: 1 online resource (x, 281 pages) : illustrations
Contents: Classical cloning, expression, and purification / Jane Skelly, Maninder K. Sohi, and Thil Batuwangala --
High-throughput cloning, expression, and purification / Raymond J. Owens [and others] --
Automation of non-conventional crystallization techniques for screening and optimization / Naomi E. Chayen --
First analysis of macromolecular crystals / Sherin S. Abdel-Meguid, David Jeruzalmi and Mark R. Sanderson --
In-house macromolecular data collection / Mark R. Sanderson --
Solving the phase problem using isomorphous replacement / Sherin S. Abdel-Meguid --
Molecular replacement techniques for high-throughput structure determination / Marc Delarue --
MAD phasing / H.M. Krishna Murthy --
Application of direct methods to macromolecular structure solution / Charles M. Weeks and William Furey --
Phase refinement through density modification / Jan Pieter Abrahams [and others] --
Getting a macromolecular model: model building, refinement, and validation / R.J. Morris, A. Perrakis and V.S. Lamzin --
High-throughput crystallographic data collection at synchrotrons / Stephen R. Wasserman [and others] --
Electron density fitting and structure validation / Mike Carson --
RNA crystallogenesis / Benoît Masquida [and others] --
Crystallography in the study of protein-DNA interaction / Maninder K. Sohi and Ivan Laponogov --
Virus crystallography / Elizabeth E. Fry, Nicola G.A. Abrescia and David I. Stuart --
Macromolecular crystallography in drug design / Sherin S. Abdel-Meguid.
Series Title: Oxford biosciences
Responsibility: edited by Mark Sanderson and Jane Skelly.

Abstract:

Macromolecular crystallography is the study of macromolecules using X-ray crystallographic techniques to determine their molecular structure. This title synthesises contributions from a team of  Read more...

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Sanderson -- In-house macromolecular data collection \/ Mark R. Sanderson -- Solving the phase problem using isomorphous replacement \/ Sherin S. Abdel-Meguid -- Molecular replacement techniques for high-throughput structure determination \/ Marc Delarue -- MAD phasing \/ H.M. Krishna Murthy -- Application of direct methods to macromolecular structure solution \/ Charles M. Weeks and William Furey -- Phase refinement through density modification \/ Jan Pieter Abrahams [and others] -- Getting a macromolecular model: model building, refinement, and validation \/ R.J. Morris, A. Perrakis and V.S. Lamzin -- High-throughput crystallographic data collection at synchrotrons \/ Stephen R. Wasserman [and others] -- Electron density fitting and structure validation \/ Mike Carson -- RNA crystallogenesis \/ Beno\u00EEt Masquida [and others] -- Crystallography in the study of protein-DNA interaction \/ Maninder K. Sohi and Ivan Laponogov -- Virus crystallography \/ Elizabeth E. Fry, Nicola G.A. 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