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Medical microbiology

Author: F H Kayser
Publisher: Stuttgart ; New York, NY : Georg Thieme Verlag, ©2005.
Edition/Format:   Print book : EnglishView all editions and formats
Summary:
While medical and hygienic developments have driven down the mortality rates of infectious diseases, pathogenic microorganisms are still a major factor in everyday clinical practice. They are still the most frequent cause of death in Third World countries. New and incurable infectious diseases are a worldwide problem. It is inescapable, therefore, that modern medicine must redouble its efforts to understand the  Read more...
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Additional Physical Format: Online version:
Medizinische Mikrobiologie. English.
Medical microbiology.
Stuttgart ; New York, NY : Georg Thieme Verlag, ©2005
(OCoLC)607552221
Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: F H Kayser
ISBN: 3131319917 9783131319913 1588902455 9781588902450
OCLC Number: 56590817
Description: xxvi, 698 pages : illustrations (some color) ; 19 cm
Contents: Machine derived contents note: Table of Contents --
I Basic principles of medical microbiology and immunology --
1 General aspects of medical microbiology --
F. H. Kayser --
1.1 The history of infectious diseases --
1.1.1 The past --
1.1.2 The Henle-Koch postulates --
1.1.3 The present --
1.2 Pathogens --
1.2.1 Subcellular infectious entities --
1.2.2 Prokaryotic and eukaryotic microorganisms --
1.2.3 Bacteria --
1.2.4 Fungi and protozoans --
1.2.5 Animals --
1.3 Host-pathogen interactions --
1.3.1 Basic terminology of infectiology --
1.3.2 Determinants of bacterial pathogenicity and virulence --
Adhesion --
Invasion and spread --
Strategies against nonspecific immunity --
Strategies against specific immunity --
Clinical disease --
Regulation of bacterial virulence --
The genetics of bacterial pathogenicity --
1.3.3 Defenses against infection --
Nonspecific defense mechanisms --
Specific defense mechanisms --
Defects in immune defenses --
1.3.4 Normal flora --
1.4 General epidemiology --
1.4.1 Epidemiological terminology --
1.4.2 Transmission, sources of infection --
Transmission --
Sources of infection --
1.4.3 The fight against infectious diseases --
Legislation --
Exposure prophylaxis --
Immunization prophylaxis --
1.5 Principles of sterilization and disinfection --
1.5.1 Terms and general introduction --
Terms --
The kinetics of germ killing --
Mechanisms of action --
1.5.2 Physical germicidal methods --
Heat --
Radiation --
Filtration --
1.5.3 Chemical germicidal methods --
1.5.4 Practical disinfection --
2 Basic principles of immunology --
R. M. Zinkernagel --
2.1 Introduction --
2.2 The immunological apparatus --
2.2.1 The B cell system --
Immunoglobulin structure --
Diversity in the variable domains of the immunoglobulins --
The different classes of immunoglobulins --
2.2.2 The T cell system --
T cell receptors (TCR) and accessory molecules --
T cell specificity and the major histocompatibility complex (MHC) --
T cell maturation: positive and negative selection --
T cell subpopulations --
2.3 Immune response types and mechanisms --
2.3.1 B cells --
B cell epitopes and B cell proliferation --
Monoclonal antibodies --
T-independent B cell responses --
2.3.2 T cells --
T cell activation --
T cell activation by superantigens --
2.3.3 Interaction between the immune cell systems --
T helper cells (CD4 T cells) and TB collaboration --
Subpopulations of T helper cells --
Cytotoxic T cells (CD8 T cells) --
Cytokines (interleukins) and adhesion --
Antibody-dependent cellular immunity and natural killer cells --
Humoral, antibody-dependent effector mechanisms --
2.3.4 The complement system --
2.3.5 Immunological cell death --
2.4 Immunological tolerance --
2.4.1 T cell tolerance --
2.4.2 B cell tolerance --
2.5 Immunological memory --
2.5.1 B cell memory --
2.5.2 T cell memory --
2.6 Immune defenses against infection and tumor immunity --
2.6.1 General rules applying to infection defenses --
2.6.2 Immune protection and immunopathology --
Influence of prophylactic immunization on the immune defenses --
2.6.3 Tumor immunity --
2.7 The pathological immune response --
2.7.1 Type I: IgE-triggered anaphylaxis --
2.7.2 Type II: Cytotoxic humoral immune responses --
Autoantibody responses --
Anti-blood group antibody reactions --
2.7.3 Type III: Diseases caused by immune complexes --
2.7.4 Type IV: Hypersensitivity or delayed-type, cell-mediated hypersensitivity --
2.8 Transplantation immunity --
2.9 Immune defects and immune response modulation --
2.9.1 Immune defects --
2.9.2 Immunoregulation --
Immunostimulation --
Immunosuppression --
Adaptive immunotherapy --
2.10 Immunological test methods --
2.10.1 Antigen and antibody assays --
Immunoprecipitation in liquids and gel mediums --
Immunoprecipitation combined with electrophoresis --
Agglutination reaction --
Complement fixation reaction (CFR) --
Direct and indirect immunofluorescence --
Radioimmunological and enzyme immunological tests --
2.10.2 In vitro cellular immunity reactions --
Isolation of lymphocytes --
Lymphocyte function tests --
Glossary --
II Bacteriology --
3 General bacteriology --
F. H. Kayser --
3.1 The morphology and fine structure of bacteria --
3.1.1 Bacterial forms --
3.1.2 Fine structures of bacteria --
Nucleoid (nucleus equivalent) and plasmids --
Cytoplasm --
The cytoplasmic membrane --
Cell wall --
Capsule --
Flagella --
Attachment pili (fimbriae), conjugation pili --
Biofilm --
Bacterial spores --
3.2 The physiology of metabolism and growth in bacteria --
3.2.1 Bacterial metabolism --
Types of metabolism --
Catabolic reactions --
Anabolic reactions --
Metabolic regulation --
3.2.2 Growth and culturing of bacteria --
Nutrients --
Growth and cell death --
3.3 The molecular basis of bacterial genetics --
3.3.1 The structure of bacterial DNA --
3.3.2 DNA replication --
3.3.3 Transcription and translation --
3.3.4 Regulation of gene expression --
3.4 The genetic variability of bacteria --
3.4.1 Molecular mechanisms of genetic variability --
Spontaneous and induced mutation --
Recombination --
3.4.2 Intercellular mechanisms of genetic variability --
Transformation --
Transduction --
Conjugation --
Restriction, modification and gene cloning --
3.5 Bacteriophages --
3.5.1 Definition --
3.5.2 Morphology --
3.5.3 Composition --
3.5.4 Reproduction --
Lysogeny --
3.6 The principles of antibiotic therapy --
3.6.1 Definitions --
3.6.2 Spectrum of action --
3.6.3 Efficacy --
3.6.4 Mechanisms of action --
3.6.5 Pharmacokinetics --
3.6.6 Side effects --
3.6.7 The problem of resistance --
Definitions --
Incidence, significance --
Resistance mechanisms --
Evolution of resistance to antiinfective agents --
Resistance tests --
3.6.8 Combination therapy --
3.6.9 Chemoprophylaxis --
3.6.10 Immunomodulators --
3.7 Laboratory diagnosis --
3.7.1 Preconditions, general methods, evaluation --
Preconditions --
General methods and evaluation --
3.7.2 Sampling and transport of test material --
3.7.3 Microscopy --
3.7.4 Culturing methods --
3.7.5 Identification of bacteria --
3.7.6 Molecular methods --
3.7.7 Direct detection of bacterial antigens --
3.7.8 Diagnostic animal tests --
3.7.9 Laboratory safety --
3.8 Taxonomy and overview of human pathogenic bacteria --
3.8.1 Classification --
3.8.2 Nomenclature --
4 Bacteria as pathogens --
F. H. Kayser --
4.1 Staphylococcus --
Staphylococcus aureus --
Coagulase-negative staphylococci (CNS) --
4.2 Streptococcus and Enterococcus --
Streptococcus pyogenes (A streptococci) --
Streptococcus pneumoniae (pneumococci) --
Streptococcus agalactiae (B streptococci) --
Oral streptococci --
Enterococcus (enterococci) --
4.3 Gram-positive, anaerobic cocci --
4.4 Bacillus --
Bacillus anthracis (anthrax) --
4.5 Clostridium --
The pathogens that cause gas gangrene (clostridial myonecrosis) and anaerobic cellulitis --
Clostridium tetani (tetanus) --
Clostridium botulinum (botulism) --
Clostridium difficile (pseudomembranous colitis) --
4.6 Listeria, Erysipelothrix and Gardnerella --
Listeria monocytogenes --
Erysipelothrix rhusiopathiae --
Gardnerella vaginalis --
4.7 Corynebacterium, Actinomyces, other gram-positive rod bacteria --
Corynebacterium diphtheriae (diphtheria) --
Actinomyces --
Other gram-positive rod bacteria --
4.8 Mycobacterium --
Tuberculosis bacteria (TB) --
Leprosy bacteria (LB) --
Nontuberculous (atypical) mycobacteria (NTM) --
4.9 Nocardia --
4.10 Neisseria, Acinetobacter and Moraxella --
Neisseria gonorrhoeae (gonorrhea) --
Neisseria meningitidis (meningitis, sepsis) --
Acinetobacter and Moraxella --
4.11 Enterobacteriaceae, overview --
4.12 Salmonella (gastroenteritis, typhoid fever, paratyphoid fever) --
4.13 Shigella (bacterial dysentery) --
4.14 Yersinia (plague, enteritis) --
Yersinia pestis --
Yersinia enterocolitica and Yersinia pseudotuberculosis --
4.15 Escherichia coli --
4.16 Opportunistic Enterobacteriaceae --
4.17 Vibrio, Aeromonas and Plesiomonas --
Vibrio cholerae (cholera) --
Other vibrio bacteria --
Aeromonas and Plesiomonas --
4.18 Haemophilus and Pasteurella --
Haemophilus influenzae --
Haemophilus ducreyi and Haemophilus aegyptius --
Pasteurella --
4.19 Other gram-negative rod bacteria --
4.20 Campylobacter, Helicobacter, Spirillum --
Campylobacter --
Helicobacter pylori --
Spirillum minus --
4.21 Pseudomonas, Stenotrophomonas, Burkholderia --
Pseudomonas aeruginosa --
Other Pseudomonas species, Stenotrophomonas and Burkholderia --
4.22 Legionella (legionnaire's disease) --
4.23 Brucella, Bordetella, Francisella --
Brucella (brucellosis, Bang disease) --
Bordetella (whooping cough, pertussis) --
Francisella tularensis (tularemia) --
4.24 Bacteroidaceae --
4.25 Treponema (syphilis, yaws, pinta) --
Treponema pallidum, subsp. pallidum (syphilis) --
Treponema pallidum, subsp. endemicum (nonvenereal syphilis) --
Treponema pallidum, subsp. pertenue (yaws) --
Treponema carateum (pinta) --
4.26 Borrelia (relapsing fever, Lyme disease, borreliosis) --
Borrelia that cause relapsing fevers --
Borrelia burgdorferi (Lyme disease) --
4.27 Leptospira (leptospirosis, Weil's syndrome) --
4.28 Rickettsia, Coxiella, Orientia and Ehrlichia --
(typhus, spotted fever, Q fever, ehrlichioses) --
4.29 Bartonella and Afipia --
Bartonella --
Afipia felis --
4.30 Chlamydia --
Overview and general characteristics of chlamydiae --
Chlamydia psittaci (ornithosis, psittacosis) --
Chlamydia trachomatis (trachoma, lymphogranuloma venereum) --
Chlamydia pneumoniae --
4.31 Mycoplasma --
4.32 Nosocomial infections --
Definition --
Pathogens, infec.
Other Titles: Medizinische Mikrobiologie.
Responsibility: Fritz H. Kayser [and others].
More information:

Abstract:

While medical and hygienic developments have driven down the mortality rates of infectious diseases, pathogenic microorganisms are still a major factor in everyday clinical practice. They are still the most frequent cause of death in Third World countries. New and incurable infectious diseases are a worldwide problem. It is inescapable, therefore, that modern medicine must redouble its efforts to understand the relationship between microorganisms and humans and continue to lead the search for new therapies. The following five subject areas are covered: Immunology, Bacteriology Mycology, Virology, Parasitology.This book provides a clearly focused and richly detailed review of the entire field of medical microbiology. It is both a textbook for students of medicine and dentistry and a useful companion for medical technicians and laboratory assistants, both at school and in the laboratory. It will also serve as a handy work of reference for clinical practitioners. The book is structured with teachability in mind: The many color illustrations and microscopic images render complex themes readily accessible. Summaries at the beginning of every chapter, a color-coded reference guide and detailed diagnostic tables make this an excellent sourcebook for rapid learning and quick reference. A list of important internet addresses in the appendix will help the book's users keep abreast of cutting-edge research.

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