Meiotic and mitotic functions of mammalian RAD 18 in DNA double-strand break repair (Book, 2010) [WorldCat.org]
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Meiotic and mitotic functions of mammalian RAD 18 in DNA double-strand break repair

Author: Akiko Inagaki
Publisher: Erasmus University Rotterdam 2010-10-22
Edition/Format: Book Book : English
Summary:
This thesis focuses on the role of RAD 18 in DNA double-strand break (DSB ) repair.Much is known about the role of RAD 18, and its critical substrate PCNA in replicationdamage bypass (RDB ) repair. However, the roles of RAD 18 in DSB repair are stillelusive, although several interaction partners of RAD 18 have been identified, and theradiation-sensitivity of Rad18 knockout cells has shown that this E3 ligase is  Read more...
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Details

Document Type: Book
All Authors / Contributors: Akiko Inagaki
ISBN: 978-94-90371-41-8
Language Note: English
Unique Identifier: 6892889012
Awards:

Abstract:

This thesis focuses on the role of RAD 18 in DNA double-strand break (DSB ) repair.Much is known about the role of RAD 18, and its critical substrate PCNA in replicationdamage bypass (RDB ) repair. However, the roles of RAD 18 in DSB repair are stillelusive, although several interaction partners of RAD 18 have been identified, and theradiation-sensitivity of Rad18 knockout cells has shown that this E3 ligase is active inDSB repair.First, a general introduction on the possible involvement of RAD 18 in DSB repairmechanisms and RDB that operate in mitotic and meiotic cells is presented in Chapter1. In Chapter 2, we examined the dynamic localization of human RAD 18 during thecell cycle and after DNA damage in living cells. The DNA damage response function

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