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MicroRNA pathways in animal development

Author: Victor Ambros; National Institutes of Health (U.S.)
Publisher: [Bethesda, Md.] : [National Institutes of Health], [2009]
Series: NIH director's Wednesday afternoon lecture series.
Edition/Format:   eVideo : National government publication : English
Summary:
(CIT): MicroRNAs are small regulatory RNA molecules, encoded in the genome, that base-pair with specific messenger RNAs and control their translation. MicroRNAs function in diverse physiological and developmental processes in animals, and in the nematode C. elegans, certain microRNAs figure prominently in the control of developmental timing by the heterochronic gene pathway. The genetic control of C. elegans  Read more...
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Details

Genre/Form: Lecture
Webcasts
Material Type: Government publication, National government publication, Internet resource, Videorecording
Document Type: Internet Resource, Computer File, Visual material
All Authors / Contributors: Victor Ambros; National Institutes of Health (U.S.)
OCLC Number: 319854703
Language Note: Open-captioned.
Notes: Title from screen banner (viewed Apr. 10, 2009).
Streaming video (1 hr., 9 min., 38 sec. : sd., col.).
Event notes: Recorded Jan. 7, 2009.
Description: 1 online resource.
Series Title: NIH director's Wednesday afternoon lecture series.
Responsibility: Victor Ambros.

Abstract:

(CIT): MicroRNAs are small regulatory RNA molecules, encoded in the genome, that base-pair with specific messenger RNAs and control their translation. MicroRNAs function in diverse physiological and developmental processes in animals, and in the nematode C. elegans, certain microRNAs figure prominently in the control of developmental timing by the heterochronic gene pathway. The genetic control of C. elegans developmental timing has provided a powerful model system for the genetic analysis of the function of certain microRNAs that are highly conserved between worms and mammals. C. elegans developmental timing mutants have moreover identified proteins that are part of the regulatory machinery associated with microRNAs and that could serve to mediate the regulation of microRNA activity by signaling pathways.

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