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MicroRNAs in diseases and disorders : emerging therapeutic targets

Author: Philip Peplow; Bridget Martinez; George A Calin; Aurora Esquela-Kerscher
Publisher: Croydon, UK : Royal Society of Chemistry, [2019] ©2019
Series: RSC drug discovery series, 69.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
MicroRNAs in Diseases and Disorders highlights the role of miRNAs in the development and progression of a variety of diseases and the utilization of miRNA targets in treatment. This book also includes the use of miRNAs as diagnostic and prognostic biomarkers for disease.
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Genre/Form: Electronic books
Additional Physical Format: Print version :
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Philip Peplow; Bridget Martinez; George A Calin; Aurora Esquela-Kerscher
ISBN: 9781788017817 1788017811 9781788016421 1788016424
OCLC Number: 1101898565
Description: 1 online resource
Contents: Intro; HalfTitle; series Editor; Title; Preface; Dedication; Copyright; Contents; Chapter 1 Role of Nutrition, the Epigenome, and MicroRNAs in Cancer Pathogenesis 1; 1.1 Introduction; 1.2 Epigenetic Link to Cancer; 1.3 miRNAs are Closely Associated with Human Cancer; 1.3.1 miRNA Biogenesis is Complex; 1.3.2 miRNAs as Tumor Suppressors and Oncogenic Factors; 1.3.3 Extracellular Delivery of miRNAs; 1.4 miRNAs and the Epigenome; 1.4.1 miRNAs that Regulate the Epigenetic Machinery; 1.4.2 miRNAs Targeted by the Epigenetic Machinery; 1.5 miRNAs, Dietary Factors, and the Epigenome; 1.5.1 Resveratrol 1.5.2 Ellagitannins and Ellagic Acid1.5.3 Epigallocatechin-3-gallate; 1.5.4 Genistein; 1.5.5 Curcumin; 1.5.6 Diindolylmethane; 1.6 miRNAs, the Microbiota, and Colon Cancer; 1.6.1 Microbial-produced Butyrate Influences Host miRNA Expression; 1.6.2 Butyrate Acts as a Histone Deacetylase Inhibitor in Cancer Cells; 1.6.3 Anti-tumor Effects of Butyrate and miRNA Expression in the Colon; 1.6.4 Butyrate's Role in Liver Cancer, the Epigenome, and miRNAs; 1.7 Plant-derived XenomiRs Impact Cancer Pathways in Human Cells; 1.7.1 Ingested Plant miRNAs Regulate Recipient Cell Targets 1.7.2 Plant miRNAs Impact Cancer Gene Expression1.8 Conclusion; Acknowledgements; References; Chapter 2 Role of MicroRNAs in Metabolic Diseases 36; 2.1 Introduction; 2.1.1 The Innate Immune System in Obesity-mediated Insulin Resistance and T2DM; 2.1.2 miRNAs and the Etiology of T2DM; 2.2 miR-122 is Elevated in Obesity and Human Metabolic Disease; 2.3 miR-126 is Downregulated in T2DM and Human Metabolic Disease; 2.4 miR-146a is Downregulated in Human Obesity and Diabetic Kidney Disease; 2.5 miR-155 is Downregulated in Human Obesity and NAFLD 2.6 miR-21 is Differentially Expressed in Obesity, T2DM, and Human Metabolic Syndrome2.7 miR-223 is Important in T2DM, Although Reports Conflict on Direction of Differential Expression; 2.8 miR-27a is Elevated in T2DM; 2.9 miR-29a is Elevated in T2DM; 2.10 miR-34a is Elevated in Obesity and T2DM; 2.11 miR-375 is Elevated in T2DM; 2.12 miRNAs as Biomarkers in Metabolic Disease; Acknowledgements; References; Chapter 3 Circulating MicroRNAs as Biomarkers of Celiac Disease and Other Intestinal Pediatric Diseases: Experimental and Bioinformatics Challenges From Bench to Bedside 76 3.1 Introduction3.1.1 Biogenesis and Regulatory Functions of miRNAs; 3.1.2 Biogenesis, Stability and Cellular Recognition of Circulating miRNAs; 3.1.3 Circulating miRNAs and Toll-like Receptors; 3.1.4 The Role of miRNAs in Intestinal Development and Homeostasis; 3.2 Celiac Disease; 3.3 Intestinal miRNAs of Celiac Disease Patients; 3.4 Circulating miRNAs of Celiac Disease Patients; 3.5 Regulation of Post-transcriptional Gene Expression by miRNAs in Celiac Disease; 3.6 Circulating miRNAs in Inflammatory Bowel Disease; 3.7 Experimental and Bioinformatics Challenges for miRNA Analysis
Series Title: RSC drug discovery series, 69.
Responsibility: edited by Philip V. Peplow, Bridget Martinez, George A. Calin and Aurora Esquela-Kercher.

Abstract:

MicroRNAs in Diseases and Disorders highlights the role of miRNAs in the development and progression of a variety of diseases and the utilization of miRNA targets in treatment. This book also  Read more...

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