컨텐츠로 이동
Mitochondrial DNA as a Breast Cancer Biomarker 해당 항목을 미리보기
닫기해당 항목을 미리보기
해당 아이템을 전자로 보기 위한 자원 선택하기

Mitochondrial DNA as a Breast Cancer Biomarker

저자: Marjolein Weerts
출판사: Erasmus University Rotterdam 2019-02-19
판/형식: 도서 도서 : English
요약:
textabstractIn this thesis, we extended the exploration on the value of cell-free DNA (cfDNA) and mitochondrial DNA (mtDNA) alterations as a cancer biomarker. First, by quantification of the number of mtDNA molecules per cell in primary tumours we explored the association with established clinicopathological biomarkers (Chapter 2 and 3), and investigated the prognostic (Chapter 2) and predictive (Chapter 3)  더 읽기…
평가:

(아무런 평가가 없습니다.) 0 리뷰와 함께 - 첫번째로 올려주세요.

온라인으로 문서 찾기

이 항목에 대한 링크

도서관에서 사본 찾기

해당 아이템을 보유하고 있는 도서관들에 대한 정보를 얻을 수 없습니다

상세정보

문서 유형 도서
모든 저자 / 참여자: Marjolein Weerts
ISBN: 978-94-6380-180-5
언어 메모: English
고유 식별자: 8089275784
상:

초록:

textabstractIn this thesis, we extended the exploration on the value of cell-free DNA (cfDNA) and mitochondrial DNA (mtDNA) alterations as a cancer biomarker. First, by quantification of the number of mtDNA molecules per cell in primary tumours we explored the association with established clinicopathological biomarkers (Chapter 2 and 3), and investigated the prognostic (Chapter 2) and predictive (Chapter 3) potential of mtDNA content in patients with breast cancer. The exploration of mtDNA as a putative biomarker in breast cancer was further extended by exploring somatic variants and expression of the mitochondrial transcriptome in primary breast cancer samples, and assessed for their association with established clinicopathological markers (Chapter 4). Next, to investigate mtDNA in blood, we set up a pipeline to analyse the genetic make-up of cfDNA in retrospective – and thus limiting amounts of – breast cancer patient material (Chapter 5). In addition, we established a sensitive and specific approach to profile mtDNA (Chapter 6). The knowledge acquired from the efforts described in Chapter 5 and 6 were applied in a cohort of retrospectively selected breast and colon cancer patients to explore the feasibility of tumour-specific mtDNA variant detection in cfDNA as a cancer biomarker (Chapter 7).

리뷰

사용자-기여 리뷰
GoodReads 리뷰 가져오는 중…
DOGObooks 리뷰를 가지고 오는 중…

태그

첫번째 되기
요청하신 것을 확인하기

이 항목을 이미 요청하셨을 수도 있습니다. 만약 이 요청을 계속해서 진행하시려면 Ok을 선택하세요.

링크된 데이터


\n\n

Primary Entity<\/h3>\n
<http:\/\/www.worldcat.org\/oclc\/8089275784<\/a>> # Mitochondrial DNA as a Breast Cancer Biomarker<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Book<\/a>, schema:CreativeWork<\/a> ;\u00A0\u00A0\u00A0\nlibrary:oclcnum<\/a> \"8089275784<\/span>\" ;\u00A0\u00A0\u00A0\nrdfs:comment<\/a> \"949 $l doctoralthesis<\/span>\" ;\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/9086685958#Thing\/mitochondrial_dna<\/a>> ; # Mitochondrial DNA<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/9086685958#Thing\/cell_free_dna<\/a>> ; # Cell-free DNA<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/9086685958#Thing\/breast_cancer<\/a>> ; # Breast cancer<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/9086685958#Thing\/biomarker<\/a>> ; # Biomarker<\/span>\n\u00A0\u00A0\u00A0\nschema:creator<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/9086685958#Person\/weerts_marjolein<\/a>> ; # Marjolein Weerts<\/span>\n\u00A0\u00A0\u00A0\nschema:datePublished<\/a> \"2019\/02\/19<\/span>\" ;\u00A0\u00A0\u00A0\nschema:description<\/a> \"textabstractIn this thesis, we extended the exploration on the value of cell-free DNA (cfDNA) and mitochondrial DNA (mtDNA) alterations as a cancer biomarker. First, by quantification of the number of mtDNA molecules per cell in primary tumours we explored the association with established clinicopathological biomarkers (Chapter 2 and 3), and investigated the prognostic (Chapter 2) and predictive (Chapter 3) potential of mtDNA content in patients with breast cancer. The exploration of mtDNA as a putative biomarker in breast cancer was further extended by exploring somatic variants and expression of the mitochondrial transcriptome in primary breast cancer samples, and assessed for their association with established clinicopathological markers (Chapter 4). Next, to investigate mtDNA in blood, we set up a pipeline to analyse the genetic make-up of cfDNA in retrospective \u2013 and thus limiting amounts of \u2013 breast cancer patient material (Chapter 5). In addition, we established a sensitive and specific approach to profile mtDNA (Chapter 6). The knowledge acquired from the efforts described in Chapter 5 and 6 were applied in a cohort of retrospectively selected breast and colon cancer patients to explore the feasibility of tumour-specific mtDNA variant detection in cfDNA as a cancer biomarker (Chapter 7).<\/span>\" ;\u00A0\u00A0\u00A0\nschema:exampleOfWork<\/a> <http:\/\/worldcat.org\/entity\/work\/id\/9086685958<\/a>> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Mitochondrial DNA as a Breast Cancer Biomarker<\/span>\" ;\u00A0\u00A0\u00A0\nschema:productID<\/a> \"8089275784<\/span>\" ;\u00A0\u00A0\u00A0\nschema:publication<\/a> <http:\/\/www.worldcat.org\/title\/-\/oclc\/#PublicationEvent\/erasmus_university_rotterdam2019_02_19<\/a>> ;\u00A0\u00A0\u00A0\nschema:publisher<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/9086685958#Agent\/erasmus_university_rotterdam<\/a>> ; # Erasmus University Rotterdam<\/span>\n\u00A0\u00A0\u00A0\nschema:url<\/a> <http:\/\/hdl.handle.net\/1765\/115118<\/a>> ;\u00A0\u00A0\u00A0\nschema:workExample<\/a> <http:\/\/worldcat.org\/isbn\/978-94-6380-180-5<\/a>> ;\u00A0\u00A0\u00A0\nwdrs:describedby<\/a> <http:\/\/www.worldcat.org\/title\/-\/oclc\/8089275784<\/a>> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n\n

Related Entities<\/h3>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/9086685958#Agent\/erasmus_university_rotterdam<\/a>> # Erasmus University Rotterdam<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nbgn:Agent<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Erasmus University Rotterdam<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/9086685958#Person\/weerts_marjolein<\/a>> # Marjolein Weerts<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Person<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Marjolein Weerts<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/9086685958#Thing\/biomarker<\/a>> # Biomarker<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Thing<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Biomarker<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/9086685958#Thing\/breast_cancer<\/a>> # Breast cancer<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Thing<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Breast cancer<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/9086685958#Thing\/cell_free_dna<\/a>> # Cell-free DNA<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Thing<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Cell-free DNA<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/9086685958#Thing\/mitochondrial_dna<\/a>> # Mitochondrial DNA<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Thing<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Mitochondrial DNA<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/hdl.handle.net\/1765\/115118<\/a>>\u00A0\u00A0\u00A0\nrdfs:comment<\/a> \"NARCIS<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/worldcat.org\/isbn\/978-94-6380-180-5<\/a>>\u00A0\u00A0\u00A0\u00A0a \nschema:ProductModel<\/a> ;\u00A0\u00A0\u00A0\nschema:isbn<\/a> \"978-94-6380-180-5<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/www.worldcat.org\/title\/-\/oclc\/#PublicationEvent\/erasmus_university_rotterdam2019_02_19<\/a>>\u00A0\u00A0\u00A0\u00A0a \nschema:PublicationEvent<\/a> ;\u00A0\u00A0\u00A0\nschema:organizer<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/9086685958#Agent\/erasmus_university_rotterdam<\/a>> ; # Erasmus University Rotterdam<\/span>\n\u00A0\u00A0\u00A0\nschema:startDate<\/a> \"2019-02-19<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n