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Mitochondrial DNA as a Breast Cancer Biomarker

著者: Marjolein Weerts
出版商: Erasmus University Rotterdam 2019-02-19
版本/格式: 图书 图书 : English
提要:
textabstractIn this thesis, we extended the exploration on the value of cell-free DNA (cfDNA) and mitochondrial DNA (mtDNA) alterations as a cancer biomarker. First, by quantification of the number of mtDNA molecules per cell in primary tumours we explored the association with established clinicopathological biomarkers (Chapter 2 and 3), and investigated the prognostic (Chapter 2) and predictive (Chapter 3)  再读一些...
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文档类型 图书
所有的著者/提供者: Marjolein Weerts
ISBN: 978-94-6380-180-5
语言注释: English
专有的标识符 8089275784
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摘要:

textabstractIn this thesis, we extended the exploration on the value of cell-free DNA (cfDNA) and mitochondrial DNA (mtDNA) alterations as a cancer biomarker. First, by quantification of the number of mtDNA molecules per cell in primary tumours we explored the association with established clinicopathological biomarkers (Chapter 2 and 3), and investigated the prognostic (Chapter 2) and predictive (Chapter 3) potential of mtDNA content in patients with breast cancer. The exploration of mtDNA as a putative biomarker in breast cancer was further extended by exploring somatic variants and expression of the mitochondrial transcriptome in primary breast cancer samples, and assessed for their association with established clinicopathological markers (Chapter 4). Next, to investigate mtDNA in blood, we set up a pipeline to analyse the genetic make-up of cfDNA in retrospective – and thus limiting amounts of – breast cancer patient material (Chapter 5). In addition, we established a sensitive and specific approach to profile mtDNA (Chapter 6). The knowledge acquired from the efforts described in Chapter 5 and 6 were applied in a cohort of retrospectively selected breast and colon cancer patients to explore the feasibility of tumour-specific mtDNA variant detection in cfDNA as a cancer biomarker (Chapter 7).

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