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Genre/Form: | Thèses et écrits académiques |
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Material Type: | Document, Thesis/dissertation, Internet resource |
Document Type: | Internet Resource, Computer File |
All Authors / Contributors: |
Hana Hazgui; Jacques Demongeot; Christian Drouet; Sylvain Sené; Georgia Barlovatz-Meimon; Alexandra Henrion-Caude; Mustapha Rachdi; Nicolas Vuillerme; Communauté d'universités et d'établissements Université Grenoble Alpes.; Université de Sfax. Faculté des sciences.; École doctorale ingénierie pour la santé, la cognition, l'environnement (Grenoble).; Âge, imagerie, modélisation (Grenoble). |
OCLC Number: | 1154803493 |
Notes: | Thèse soutenue en co-tutelle. Titre provenant de l'écran-titre. |
Description: | 1 online resource |
Responsibility: | Hana Hazgui ; sous la direction de Jacques Demongeot. |
Abstract:
In this thesis, we focus on statistical modeling of biological data, and more particularly on the study of genetic and protein information.First, we have improved a statistical model of existing immunological data in mice, we have transposed it to human, in order to study the various recombinations that occur within the thymus, at the end of the embryonic life, between segments of genes from the portion V (D) J of the human chromosome 14, called recombinations V (D) J.Secondly, we studied the genetic information through genetic regulatory networks, for example in the case of a family illness called the "biliary atresia," as well as in the immune system control networks, which we have called "Immunetworks".In a last part, we propose a new approach for biological data compression, which includes a step of modeling the dynamic processes that gave rise to them: we call this approach the "Dynalet" transform and we apply it, among others, to NMR spectrometry signals, i.e., Nuclear Magnetic Resonance spectra of proteins and nucleic acids. This method consists in converting the peaks of the spectrometric signals into sounds, in order to construct an anharmonic instrument capable to reproduce periodized relaxation peaks from the NMR spectra of the 20 amino acids, as well as those of the 4 nucleic bases.
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