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Molecular pharming : applications, challenges, and emerging areas

Author: Allison R Kermode; Liwen Jiang
Publisher: Hoboken, NJ : Wiley Blackwell, 2018.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
A single volume collection that surveys the exciting field of plant-made pharmaceuticals and industrial proteins This comprehensive book communicates the recent advances and exciting potential for the expanding area of plant biotechnology and is divided into six sections. The first three sections look at the current status of the field, and advances in plant platforms and strategies for improving yields, downstream  Read more...
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Genre/Form: Electronic books
Additional Physical Format: ebook version :
(DLC) 2018275577
(OCoLC)1047641557
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Allison R Kermode; Liwen Jiang
ISBN: 9781118801512 1118801512 9781118801482 1118801482 9781118801505 1118801504 1118801288 9781118801284
OCLC Number: 1028640808
Notes: Includes index.
Description: 1 online resource
Contents: The Molecular Farming/Pharming Landscape. Current Status and Perspectives of the Molecular Farming Landscape / Holger Spiegel, Eva Stöger, Richard M Twyman, Johannes F Buyel --
Molecular Biology of Plant Expression Systems and Manipulation of Glycosylation Processes in Plants. Synthetic Transcription Activator-Like Effector-Activated Promoters for Coordinated Orthogonal Gene Expression in Plants / Tom Schreiber, Alain Tissier --
Contemporary and Emerging Technologies for Precise N-glycan Analyses / Iain BH Wilson, Katharina Paschinger, Jorick Vanbeselaere, Chunsheng Jin --
Production of Functionally Active Recombinant Proteins in Plants / Alexandra Castilho, Richard Strasser --
Plant Platforms, Subcellular Targeting, Recovery, and Downstream Processing. Seeds as Bioreactors / Jinbo Shen, Xiangfeng Wang, Liwen Jiang --
Strategies to Increase Expression and Accumulation of Recombinant Proteins / Reza Saberianfar, Rima Menassa --
The Impact of Six Critical Impurities on Recombinant Protein Recovery and Purification from Plant Hosts / Chelsea Dixon, Lisa R Wilken, Susan L Woodard, Georgia OF Barros --
Plant Recombinant Lysosomal Enzymes as Replacement Therapeutics for Lysosomal Storage Diseases / Allison R Kermode, Grant McNair, Owen Pierce --
Plant-Derived Protein Pharmaceuticals and Case Studies. Plant-Produced Antibodies and Post-Translational Modification / Andreas Loos, Herta Steinkellner --
Molecular Pharming / Qiang Chen, Matthew Dent, Hugh Mason --
Transgenic Rice for the Production of Recombinant Pharmaceutical Proteins / Daichang Yang, Jiquan Ou, Jingni Shi, Zhibin Guo, Bo Shi, Naghmeh Abiri --
Enzymes for Industrial and Pharmaceutical Applications --
From Individual to Population Level Impact / Elizabeth E Hood, Carole L Cramer --
Regulatory Issues. Biosafety, Risk Assessment, and Regulation of Molecular Farming / Penny AC Hundleby, Markus Sack, Richard M Twyman --
Emerging Areas. Harnessing Plant Trichome Biochemistry for the Production of Useful Compounds / Alain Tissier --
Reconstitution of Medicinally Important Plant Natural Products in Microorganisms / Ozkan Fidan, Jixun Zhan --
Screening of Epidermal Growth Factor Receptor Inhibitors in Natural Products Derived From Extracts of Traditional Chinese Medicines / Li Feng, Jingwu Kang --
Target-Directed Evolution of Mutant Transgenic Plant Cells as a Novel Source of Drugs / John Littleton, Dustin Brown, Deane Falcone, Gregory Gerhardt, Samir Gunjan, Dennis T Rogers, Jatinder Sambi --
Plant Thermotolerance Proteins, Misfolded Proteins, and Neurodegenerative Diseases / Indranil Basak, Simon G Møller.
Responsibility: editor, Allison R. Kermode ; associate editor, Liwen Jiang.

Abstract:

A single volume collection that surveys the exciting field of plant-made pharmaceuticals and industrial proteins This comprehensive book communicates the recent advances and exciting potential for the expanding area of plant biotechnology and is divided into six sections. The first three sections look at the current status of the field, and advances in plant platforms and strategies for improving yields, downstream processing, and controlling post-translational modifications of plant-made recombinant proteins. Section four reviews high-value industrial and pharmacological proteins that are successfully being produced in established and emerging plant platforms. The fifth section looks at regulatory challenges facing the expansion of the field. The final section turns its focus toward small molecule therapeutics, drug screening, plant specialized metabolites, and plants as model organisms to study human disease processes. Molecular Pharming: Applications, Challenges and Emerging Areas offers in-depth coverage of molecular biology of plant expression systems and manipulation of glycosylation processes in plants; plant platforms, subcellular targeting, recovery, and downstream processing; plant-derived protein pharmaceuticals and case studies; regulatory issues; and emerging areas. It is a valuable resource for researchers that are in the field of plant molecular pharming, as well as for those conducting basic research in gene expression, protein quality control, and other subjects relevant to molecular and cellular biology.-Broad ranging coverage of a key area of plant biotechnology -Describes efforts to produce pharmaceutical and industrial proteins in plants -Provides reviews of recent advances and technology breakthroughs -Assesses realities of regulatory and cost hurdles -Forward looking with coverage of small molecule technologies and the use of plants as models of human disease processes Providing wide-ranging and unique coverage, Molecular Pharming: Applications, Challenges and Emerging Areas will be of great interest to the plant science, plant biotechnology, protein science, and pharmacological communities.

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