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The mRNA metabolism in human disease

Author: Luísa Romão
Publisher: Cham : Springer, [2019] ©2019
Series: Advances in experimental medicine and biology, v. 1157.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
The eukaryotic gene expression pathway involves a number of interlinked steps, with messenger RNA (mRNA) being the key intermediate. The precursor mRNA is transcribed from DNA, processed by removal of introns and addition of the cap structure and the poly(A) tail. The mature mRNA is then exported to the cytoplasm where it is translated into protein and finally degraded. In this process, mRNA is associated with  Read more...
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Genre/Form: Electronic books
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Luísa Romão
ISBN: 9783030199661 3030199665
OCLC Number: 1114289088
Description: 1 online resource : illustrations (some color)
Contents: Prelims --
Networks of mRNA processing and alternative splicing regulation in health and disease --
The diverse roles of RNA-binding proteins in glioma development --
Nonsense-mediated mRNA decay in development, stress and cancer --
Implication of mRNA degradation disorders on human DISease: focus on DIS3 and DIS3-like enzymes --
Translational regulation by upstream open reading frames and human diseases --
Alternative mechanisms of mRNA translation initiation in cellular stress response and cancer --
RNA therapeutics: how far have we gone? Index.
Series Title: Advances in experimental medicine and biology, v. 1157.
Responsibility: Luísa Romão, editor.

Abstract:

The eukaryotic gene expression pathway involves a number of interlinked steps, with messenger RNA (mRNA) being the key intermediate. Although eukaryotic cells have evolved elaborate mRNA quality  Read more...

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Index.<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\nschema:description<\/a> \"The eukaryotic gene expression pathway involves a number of interlinked steps, with messenger RNA (mRNA) being the key intermediate. The precursor mRNA is transcribed from DNA, processed by removal of introns and addition of the cap structure and the poly(A) tail. The mature mRNA is then exported to the cytoplasm where it is translated into protein and finally degraded. In this process, mRNA is associated with RNA-binding proteins forming ribonucleoprotein complexes, whose protein content evolves throughout the lifetime of the mRNA. While the complexity of eukaryotic gene expression allows the production of proteins to be controlled at many levels, it also makes the process vulnerable to errors. Although eukaryotic cells have evolved elaborate mRNA quality control mechanisms that ensure the fidelity of gene expression, some defects are not detected, thus affecting mRNA metabolism. This condition plays a fundamental role in the pathogenesis of several disease processes, such as neurodegeneration and oncogenesis. Besides, exciting recent data have shown that cellular RNAs can be modified post-transcriptionally via dynamic and reversible chemical modifications, the so-called epitranscriptome. These modifications can alter mRNA structure, being able to modulate different steps of the mRNA metabolism that can be associated with various human diseases, such as systemic lupus erythematosus and cancer. This book provides a collection of novel studies and hypotheses aimed to define the pathophysiological consequences of altered mRNA metabolism events in human cells, and is written for a wide spectrum of readers in the field of gene expression regulation. The last chapter highlights how the discovery of disease-causing defects (or modifications) in mRNA can provide a variety of therapeutic targets that can be used for the development of new RNA-based therapeutics. 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