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Multiscale modeling of vascular dynamics of micro- and nano-particles : application to drug delivery system

Author: Huilin Ye, (Mechanical engineer); Zhiqiang Shen, (Mechanical engineer); Ying Li, (Ph. D. in mechanical engineering); Morgan & Claypool Publishers,; Institute of Physics (Great Britain),
Publisher: San Rafael [California] (40 Oak Drive, San Rafael, CA, 94903, USA) : Morgan & Claypool Publishers, Bristol [England] (Temple Circus, Temple Way, Bristol BS1 6HG, UK) : IOP Publishing, [2019] [2019]
Series: IOP concise physics.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Recent advances in this exciting field see the potential to employ nanomedicine and game-changing methods to deliver drug molecules directly to diseased sites. To optimize and then enhance efficacy and specificity, the control and guidance of drug carriers in vasculature become crucial. The current bottlenecks in the optimal design of drug-carrying particles are lack of knowledge about the transport of particles,  Read more...
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Details

Genre/Form: Electronic books
Additional Physical Format: Print version:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Huilin Ye, (Mechanical engineer); Zhiqiang Shen, (Mechanical engineer); Ying Li, (Ph. D. in mechanical engineering); Morgan & Claypool Publishers,; Institute of Physics (Great Britain),
ISBN: 9781643277929 1643277928 9781643277905 1643277901
OCLC Number: 1135509960
Notes: "Version: 20191201"--Title page verso.
"A Morgan & Claypool publication as part of IOP Concise Physics"--Title page verso.
Description: 1 online resource : illustrations (some color).
Contents: 1. Background --
1.1. Blood flow in human vasculature --
1.2. Vascular targeting and margination of particles in blood flow --
1.3. Adhesion of particles on endothelium wall part I. Numerical method --
2. Numerical methods: fluid-structure interaction and adhesive dynamics --
2.1. Fluid-structure interaction --
2.2. Adhesive dynamics --
2.3. Validation of numerical method part II. Applications --
3. Anomalous vascular dynamics of nanoworms within blood flow --
3.1. Motivation --
3.2. Experimental and computational results 4. Adhesion behavior of a single cell on the endothelial wall --
4.1. Introduction --
4.2. Computational model --
4.3. Results and discussion 5. Localization of soft particles: margination and adhesion --
5.1. Introduction --
5.2. Physical problem and computational method --
5.3. Results and discussion 6. Shape-dependent transport of micro-particles in blood flow: from margination to adhesion --
6.1. Introduction --
6.2. Computational model setup --
6.3. Results and discussion 7. Conclusion and perspective --
Appendix A. Coarse-grained potential for RBCs.
Series Title: IOP concise physics.
Responsibility: Huilin Ye, Zhiqiang Shen and Ying Li.

Abstract:

To study the transport and adhesion of particle in vasculature, this study numerically investigates the dynamic and adhesive motions of particles in the blood flow. The book discusses recent  Read more...

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