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Multivalency : Concepts, Research and Applications.

Author: Jurriaan Huskens; Rainer Haag; Bart Jan Ravoo; Leonard J Prins; E W Meijer
Publisher: Newark : John Wiley & Sons, Incorporated, 2017.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Connects fundamental knowledge of multivalent interactions with current practice and state-of-the-art applications Multivalency is a widespread phenomenon, with applications spanning supramolecular chemistry, materials chemistry, pharmaceutical chemistry and biochemistry. This advanced textbook provides students and junior scientists with an excellent introduction to the fundamentals of multivalent interactions,  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Huskens, Jurriaan.
Multivalency : Concepts, Research and Applications.
Newark : John Wiley & Sons, Incorporated, ©2017
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Jurriaan Huskens; Rainer Haag; Bart Jan Ravoo; Leonard J Prins; E W Meijer
ISBN: 9781119143475 1119143470
OCLC Number: 1013820144
Description: 1 online resource (437 pages)
Contents: Intro --
Title Page --
Copyright Page --
Contents --
List of Contributors --
Foreword --
Preface --
Part I General Introduction to Multivalent Interactions --
Chapter 1 Additivity of Energy Contributions in Multivalent Complexes --
1.1 Introduction --
1.2 Additivity of Single Interactions --
Examples --
1.3 Limitations of Additivity --
1.3.1 Free Energy Values ?G Instead of Enthalpic and Entropic Values ?H, T?S --
1.3.2 Mismatch as Limitation of Additivity --
1.3.3 Medium Effects as Limiting Factor --
1.3.4 Strain and Induced Fit --
1.4 Cooperativity --
1.5 Allostery --
1.6 Conclusions --
References --
Chapter 2 Models and Methods in Multivalent Systems --
2.1 Introduction --
2.1.1 General Introduction --
2.1.2 Multivalent versus Cooperative Interactions --
2.2 Numerical Data Analysis --
2.2.1 Model Simulations Using a Spreadsheet Approach --
2.2.2 Setting Up and Assessing Titrations --
2.2.3 Using Spreadsheet Simulations to Fit Experimental Data to a Model --
2.3 Models for Multivalent Systems --
2.3.1 The Simplest Multivalent System: A 1:1 Complex with Two Interaction Sites --
2.3.2 Multivalent Binding at Surfaces --
2.4 Special Multivalent Systems --
2.4.1 Increasing the Valency of Interfacial Assemblies: Dendrimers, Oligomers, and Polymers --
2.4.2 Heterotropic Interactions --
2.4.3 Kinetics and Dynamics --
2.5 Conclusions --
Acknowledgments --
References --
Chapter 3 Design Principles for Super Selectivity using Multivalent Interactions --
3.1 Introduction --
3.1.1 Background: Ultra-sensitive Response --
3.2 Super Selectivity: An Emergent Property of Multivalency --
3.3 Multivalent Polymer Adsorption --
3.4 Which Systems are Super Selective? --
3.4.1 Rigid Geometry Interactions --
3.4.2 Disordered Multivalency --
3.5 Design Principles for Super{u2010}Selective Targeting --
3.6 Summary: It is interesting, but is it useful?. Appendix 3.A: What Is Effective Molarity? --
Acknowledgements --
References --
Chapter 4 Multivalency in Biosystems --
4.1 Introduction --
4.2 Cell-Cell Adhesion --
4.2.1 Homotypic Interactions, Cadherins Keep Cells Together --
4.2.2 Selectins, Heterotypic Cell Adhesion to Fight Infections --
4.2.3 Bacterial Adhesion by FimH --
4.3 Phase Transition, Multivalent Intracellular Assemblies --
4.4 Multivalency in the Fluid Phase, Pathogen Opsonization --
4.5 Conclusion --
Acknowledgment --
References --
Part II Multivalent Systems in Chemistry --
Chapter 5 Multivalency in Cyclodextrin/Polymer Systems --
5.1 Introduction --
5.2 General Perspectives of Multivalency in Cyclodextrin/Polymer Systems --
5.3 Typical Examples of Multivalency in Cyclodextrin/Polymer Systems --
5.3.1 Formation of Polymer Aggregates from Cyclodextrin-Polymers and Guest-Polymers --
5.3.2 Selectivity of Interaction Enhanced by Multivalency --
5.3.3 Self-Healable Hydrogels Based on Multivalency --
5.4 Summary and Outlook --
Acknowledgments --
References --
Chapter 6 Cucurbit[n]uril-Mediated Multiple Interactions --
6.1 Introduction to Cucurbit[n]uril Chemistry --
6.2 Heteroternary Complexes --
6.3 Homoternary Complexes --
6.4 Conclusions --
References --
Chapter 7 Multivalency as a Design Criterion in Catalyst Development --
7.1 Introduction --
7.2 Formation of Enzyme{u2010}Like Catalytic Pockets --
7.3 Cooperativity Between Functional Groups --
7.4 Mechanistic Effects --
7.5 The Dendritic Effect in Multivalent Nanozymes --
7.5.1 Peptide-Based Dendrimers for the Cleavage of Phosphodiesters --
7.5.2 Catalytic 3D SAMs on Au NPs --
7.6 Multivalent Catalysts and Multivalent Substrates --
7.7 Conclusions --
Acknowledgements --
References --
Chapter 8 Multivalent Molecular Recognition on the Surface of Bilayer Vesicles --
8.1 Introduction --
8.2 Molecular Recognition of Vesicles. 8.2.1 Metal Coordination --
8.2.2 Light Responsive Interactions --
8.2.3 Hydrogen Bonding and Electrostatic Interactions --
8.3 Biomimetic Vesicles --
8.3.1 Vesicles as Multivalent Platforms --
8.3.2 Membrane Fusion --
8.4 Vesicle-based Supramolecular Materials --
8.4.1 Hydrogels --
8.4.2 Immobilization of Vesicles --
8.4.3 Nanoparticles and Nanocontainers --
8.5 Conclusion --
Acknowledgment --
References --
Part III Multivalent Systems in Biology --
Chapter 9 Blocking Pathogens by Multivalent Inhibitors --
9.1 Introduction --
9.2 Design of Multivalent Ligand Architectures --
9.3 Multivalent Carbohydrate Ligands --
9.4 Scaffold Architecture --
9.4.1 Linear and Dendritic Scaffolds --
9.4.2 Multivalent Gold Nanoparticles --
9.4.3 2D Platforms --
9.5 Nano- and Microgels for Pathogen Inhibition --
9.6 Conclusion --
Acknowledgments --
References --
Chapter 10 Multivalent Protein Recognition Using Synthetic Receptors --
10.1 Introduction --
10.2 Structural Properties of Protein Surfaces --
10.2.1 Protein-Protein Interfacial Areas --
10.2.2 Chemical Nature of the Protein-Protein Interface --
10.2.3 "Hot Spots" --
10.2.4 O-Ring Structure --
10.3 Synthetic Receptors for Protein Surface Recognition --
10.3.1 Porphyrin Scaffolds for Protein Surface Recognition --
10.3.2 Protein Surface Recognition Using Molecular Tweezers --
10.3.3 Calixarene Scaffolds for Protein Surface Recognition --
10.3.4 Recognition of Protein Surfaces Using Nanoparticles --
10.3.4.1 Nanoparticles as Protein Mimics --
10.3.4.2 Regulating the Structure and Function of Proteins Using Nanoparticles --
10.3.4.3 Nanoparticle-based Protein Sensors --
10.4 Future Perspective and Challenges --
Acknowledgment --
References --
Chapter 11 Multivalent Calixarenes for the Targeting of Biomacromolecules --
11.1 Introduction --
11.2 Binding to Proteins and Enzymes. 11.3 Recognition of Carbohydrate Binding Proteins (Lectins) --
11.4 Binding Polyphosphates, Oligonucleotides and Nucleic Acids --
11.5 Conclusions --
Acknowledgements --
References --
Chapter 12 Cucurbit[n]uril Assemblies for Biomolecular Applications --
12.1 Introduction --
12.2 Molecular Recognition Properties of CB[n] --
12.2.1 Interactions with the Carbonyl Portals of CB[n] --
12.2.2 Release of High Energy Water Molecules from the CB[n] Cavity --
12.2.3 Enthalpy-driven Hydrophobic Effect for CB[n] --
12.2.4 Enthalpy-driven Hydrophobic Effect for CB[8] Heteroternary Complexes --
12.3 Control Over the Binding Affinity with CB[n] --
12.4 CB[n] Recognition of Amino Acids, Peptides, and Proteins --
12.5 CB[n] for Bioanalytical and Biomedical Applications --
12.5.1 CB[n]-mediated Assembly of Bioactive Polymers and Hydrogels --
12.5.2 CB[n]-mediated Assembly of Bioactive Nanoparticles --
12.5.3 CB[n]-mediated Assembly on Bioactive Surfaces --
12.6 Conclusions and Outlook --
Acknowledgment --
References --
Chapter 13 Multivalent Lectin-Glycan Interactions in the Immune System --
13.1 Introduction --
13.2 Targeting Innate Immunity to Shape Adaptive Immunity --
13.3 C-type Lectin Receptors --
13.3.1 Multivalent Glycoconjugates Targeting DC-SIGN --
13.3.2 Multivalent Glycoconjugates Targeting Other CLRs --
13.4 Galectins --
13.5 Siglecs --
13.6 Conclusions --
Acknowledgment --
References --
Chapter 14 Blocking Disease Linked Lectins with Multivalent Carbohydrates --
14.1 Introduction --
14.2 Haemagglutinin --
14.3 LecA --
14.4 LecB --
14.5 Galectins --
14.6 Concanavalin A --
14.7 Cholera Toxin --
14.8 Propeller Lectins --
14.9 Conclusion --
Acknowledgements --
References --
Index --
Supplemental Images --
EULA.

Abstract:

Connects fundamental knowledge of multivalent interactions with current practice and state-of-the-art applications Multivalency is a widespread phenomenon, with applications spanning supramolecular chemistry, materials chemistry, pharmaceutical chemistry and biochemistry. This advanced textbook provides students and junior scientists with an excellent introduction to the fundamentals of multivalent interactions, whilst expanding the knowledge of experienced researchers in the field. Multivalency: Concepts, Research & Applications is divided into three parts. Part one provides background knowledge on various aspects of multivalency and cooperativity and presents practical methods for their study. Fundamental aspects such as thermodynamics, kinetics and the principle of effective molarity are described, and characterisation methods, experimental methodologies and data treatment methods are also discussed. Parts two and three provide an overview of current systems in which multivalency plays an important role in chemistry and biology, with a focus on the design rules, underlying chemistry and the fundamental principles of multivalency. The systems covered range from chemical/materials-based ones such as dendrimers and sensors, to biological systems including cell recognition and protein binding. Examples and case studies from biochemistry/bioorganic chemistry as well as synthetic systems feature throughout the book.-Introduces students and young scientists to the field of multivalent interactions and assists experienced researchers utilising the methodologies in their work -Features examples and case studies from biochemistry/bioorganic chemistry, as well as synthetic systems throughout the book -Edited by leading experts in the field with contributions from established scientists Multivalency: Concepts, Research & Applications is recommended for graduate students and junior scientists in supramolecular chemistry and related fields, looking for an introduction to multivalent interactions. It is also highly useful to experienced academics and scientists in industry working on research relating to multivalent and cooperative systems in supramolecular chemistry, organic chemistry, pharmaceutical chemistry, chemical biology, biochemistry, materials science and nanotechnology.

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