skip to content
Myocardinal contractility and oxygen regulation as a determinant of myocardinal plasticity in the hypoxia and hyperoxia reared American alligator, Alligator mississippiensis Preview this item
ClosePreview this item
Checking...

Myocardinal contractility and oxygen regulation as a determinant of myocardinal plasticity in the hypoxia and hyperoxia reared American alligator, Alligator mississippiensis

Author: Leah Parrila
Publisher: [Long Beach, California] : California State University, Long Beach, 2013.
Dissertation: M.S. California State University, Long Beach 2013
Series: California State University, Long Beach.; Master's thesis collection, Dept. of Biological Sciences.
Edition/Format:   Thesis/dissertation : Document : Thesis/dissertation   Computer File : English
Summary:
Abstract: American alligator, Alligator mississippiensis (A.m.), is an ectothermic vertebrate with unique cardiac and metabolic physiology. Alligators are part of the crocodilian family known to be distant relatives of the ancient Archosauria clade which date back nearly 250 million years ago when atmospheric oxygen levels were thought to fluctuate between 16% and 36%. Alligators were reared in chronic hypoxia and  Read more...
Rating:

(not yet rated) 0 with reviews - Be the first.

Subjects
More like this

Find a copy online

Links to this item

Find a copy in the library

&AllPage.SpinnerRetrieving; Finding libraries that hold this item...

Details

Genre/Form: Academic theses
Material Type: Document, Thesis/dissertation, Internet resource
Document Type: Book, Computer File, Internet Resource
All Authors / Contributors: Leah Parrila
ISBN: 9781303766800 1303766809
OCLC Number: 1015535383
Description: 2, v, 44 leaves : illustrations
Series Title: California State University, Long Beach.; Master's thesis collection, Dept. of Biological Sciences.
Responsibility: by Leah Parrila.

Abstract:

Abstract: American alligator, Alligator mississippiensis (A.m.), is an ectothermic vertebrate with unique cardiac and metabolic physiology. Alligators are part of the crocodilian family known to be distant relatives of the ancient Archosauria clade which date back nearly 250 million years ago when atmospheric oxygen levels were thought to fluctuate between 16% and 36%. Alligators were reared in chronic hypoxia and hyperoxia. Cardiac proteins were measured as an indicator of myocardial remodeling in response to alterations in atmospheric oxygen. Myosin heavy-chain (MyHC), a major cardiac contractile protein, was expressed at 100% MyHC-p in the left ventricle and 100% MyHC-a in the left atria. The right atria and the right ventricle expressed a shift in isoform expression from MyHC-a to MyHC-p as alligator age increased. Investigation of oxygen transport by cytoplasmic heme protein Myoglobin (Mb) did not reveal significant differences between oxygen groups although a decreasing trend in relative Mb expression was evident from pre-hatchling to post-hatchling time points. We did not find evidence that ubiquitin protease, MAFbx, contributed to hypertrophic growth by significantly increasing proteosomal degradation of cardiomyocytes. These findings suggest alligator myocardial plasticity is being regulated by alternative mechanisms. Further investigation is warranted to better understand the survival and success of this taxon under altered environmental conditions of oxygen.

Reviews

User-contributed reviews
Retrieving GoodReads reviews...
Retrieving DOGObooks reviews...

Tags

Be the first.
Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Linked Data


Primary Entity

<http://www.worldcat.org/oclc/1015535383> # Myocardinal contractility and oxygen regulation as a determinant of myocardinal plasticity in the hypoxia and hyperoxia reared American alligator, Alligator mississippiensis
    a schema:Book, bgn:Thesis, schema:MediaObject, schema:CreativeWork ;
    bgn:inSupportOf "" ;
    library:oclcnum "1015535383" ;
    library:placeOfPublication <http://id.loc.gov/vocabulary/countries/cau> ;
    library:placeOfPublication <http://experiment.worldcat.org/entity/work/data/4673255449#Place/long_beach_california> ; # Long Beach, California
    schema:about <http://experiment.worldcat.org/entity/work/data/4673255449#Topic/oxygen_physiological_transport> ; # Oxygen--Physiological transport
    schema:about <http://experiment.worldcat.org/entity/work/data/4673255449#Topic/myoglobin> ; # Myoglobin
    schema:about <http://experiment.worldcat.org/entity/work/data/4673255449#Topic/heart_physiology> ; # Heart--Physiology
    schema:about <http://experiment.worldcat.org/entity/work/data/4673255449#Topic/american_alligator_physiology> ; # American alligator--Physiology
    schema:about <http://experiment.worldcat.org/entity/work/data/4673255449#Topic/oxygen_physiological_effect> ; # Oxygen--Physiological effect
    schema:creator <http://experiment.worldcat.org/entity/work/data/4673255449#Person/parrila_leah> ; # Leah Parrila
    schema:datePublished "2013" ;
    schema:description "Abstract: American alligator, Alligator mississippiensis (A.m.), is an ectothermic vertebrate with unique cardiac and metabolic physiology. Alligators are part of the crocodilian family known to be distant relatives of the ancient Archosauria clade which date back nearly 250 million years ago when atmospheric oxygen levels were thought to fluctuate between 16% and 36%. Alligators were reared in chronic hypoxia and hyperoxia. Cardiac proteins were measured as an indicator of myocardial remodeling in response to alterations in atmospheric oxygen. Myosin heavy-chain (MyHC), a major cardiac contractile protein, was expressed at 100% MyHC-p in the left ventricle and 100% MyHC-a in the left atria. The right atria and the right ventricle expressed a shift in isoform expression from MyHC-a to MyHC-p as alligator age increased. Investigation of oxygen transport by cytoplasmic heme protein Myoglobin (Mb) did not reveal significant differences between oxygen groups although a decreasing trend in relative Mb expression was evident from pre-hatchling to post-hatchling time points. We did not find evidence that ubiquitin protease, MAFbx, contributed to hypertrophic growth by significantly increasing proteosomal degradation of cardiomyocytes. These findings suggest alligator myocardial plasticity is being regulated by alternative mechanisms. Further investigation is warranted to better understand the survival and success of this taxon under altered environmental conditions of oxygen."@en ;
    schema:exampleOfWork <http://worldcat.org/entity/work/id/4673255449> ;
    schema:genre "Academic theses"@en ;
    schema:inLanguage "en" ;
    schema:isPartOf <http://experiment.worldcat.org/entity/work/data/4673255449#Series/master_s_thesis_collection_dept_of_biological_sciences> ; # Master's thesis collection, Dept. of Biological Sciences.
    schema:name "Myocardinal contractility and oxygen regulation as a determinant of myocardinal plasticity in the hypoxia and hyperoxia reared American alligator, Alligator mississippiensis"@en ;
    schema:productID "1015535383" ;
    schema:publication <http://www.worldcat.org/title/-/oclc/1015535383#PublicationEvent/long_beach_california_california_state_university_long_beach_2013> ;
    schema:publisher <http://experiment.worldcat.org/entity/work/data/4673255449#Agent/california_state_university_long_beach> ; # California State University, Long Beach
    schema:url <http://search.proquest.com/docview/1515071412?accountid=10351> ;
    schema:workExample <http://worldcat.org/isbn/9781303766800> ;
    wdrs:describedby <http://www.worldcat.org/title/-/oclc/1015535383> ;
    .


Related Entities

<http://experiment.worldcat.org/entity/work/data/4673255449#Agent/california_state_university_long_beach> # California State University, Long Beach
    a bgn:Agent ;
    schema:name "California State University, Long Beach" ;
    .

<http://experiment.worldcat.org/entity/work/data/4673255449#Organization/california_state_university_long_beach> # California State University, Long Beach.
    a schema:Organization ;
    schema:name "California State University, Long Beach." ;
    .

<http://experiment.worldcat.org/entity/work/data/4673255449#Person/parrila_leah> # Leah Parrila
    a schema:Person ;
    schema:familyName "Parrila" ;
    schema:givenName "Leah" ;
    schema:name "Leah Parrila" ;
    .

<http://experiment.worldcat.org/entity/work/data/4673255449#Place/long_beach_california> # Long Beach, California
    a schema:Place ;
    schema:name "Long Beach, California" ;
    .

<http://experiment.worldcat.org/entity/work/data/4673255449#Series/master_s_thesis_collection_dept_of_biological_sciences> # Master's thesis collection, Dept. of Biological Sciences.
    a bgn:PublicationSeries ;
    schema:creator <http://experiment.worldcat.org/entity/work/data/4673255449#Organization/california_state_university_long_beach> ; # California State University, Long Beach.
    schema:hasPart <http://www.worldcat.org/oclc/1015535383> ; # Myocardinal contractility and oxygen regulation as a determinant of myocardinal plasticity in the hypoxia and hyperoxia reared American alligator, Alligator mississippiensis
    schema:name "Master's thesis collection, Dept. of Biological Sciences." ;
    schema:name "[Master's thesis collection, Dept. of Biological Sciences]" ;
    .

<http://experiment.worldcat.org/entity/work/data/4673255449#Topic/american_alligator_physiology> # American alligator--Physiology
    a schema:Intangible ;
    schema:name "American alligator--Physiology"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/4673255449#Topic/heart_physiology> # Heart--Physiology
    a schema:Intangible ;
    schema:name "Heart--Physiology"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/4673255449#Topic/oxygen_physiological_effect> # Oxygen--Physiological effect
    a schema:Intangible ;
    schema:name "Oxygen--Physiological effect"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/4673255449#Topic/oxygen_physiological_transport> # Oxygen--Physiological transport
    a schema:Intangible ;
    schema:name "Oxygen--Physiological transport"@en ;
    .

<http://worldcat.org/isbn/9781303766800>
    a schema:ProductModel ;
    schema:isbn "1303766809" ;
    schema:isbn "9781303766800" ;
    .

<http://www.worldcat.org/title/-/oclc/1015535383>
    a genont:InformationResource, genont:ContentTypeGenericResource ;
    schema:about <http://www.worldcat.org/oclc/1015535383> ; # Myocardinal contractility and oxygen regulation as a determinant of myocardinal plasticity in the hypoxia and hyperoxia reared American alligator, Alligator mississippiensis
    schema:dateModified "2019-06-28" ;
    void:inDataset <http://purl.oclc.org/dataset/WorldCat> ;
    .


Content-negotiable representations

Close Window

Please sign in to WorldCat 

Don't have an account? You can easily create a free account.