skip to content
A nano-composite for cardiovascular tissue engineering Preview this item
ClosePreview this item
Checking...

A nano-composite for cardiovascular tissue engineering

Author: Ajay Shirolkar
Publisher: [Long Beach, California] : California State University, Long Beach, 2018.
Dissertation: M.S. California State University, Long Beach 2018
Series: California State University, Long Beach.; Master's thesis collection, Department of Mechanical and Aerospace Engineering.
Edition/Format:   Thesis/dissertation : Thesis/dissertation : eBook   Computer File : English
Summary:
Abstract: Cardiovascular disease (CVD) is one of the largest epidemic in the world causing 800,000 annual deaths in the U.S alone and 15 million deaths worldwide. After a myocardial infarction, commonly known as a heart attack, the cells around the infarct area get deprived of oxygen and die resulting in scar tissue formation and subsequent arrhythmic beating of the heart. Due to the inability of cardiomyocytes to  Read more...
Rating:

(not yet rated) 0 with reviews - Be the first.

Subjects
More like this

Find a copy online

Links to this item

Find a copy in the library

&AllPage.SpinnerRetrieving; Finding libraries that hold this item...

Details

Material Type: Thesis/dissertation, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Ajay Shirolkar
ISBN: 9780438633667 0438633660
OCLC Number: 1083724395
Description: 1 online resource (viii, 48 pages) : illustrations (some color).
Series Title: California State University, Long Beach.; Master's thesis collection, Department of Mechanical and Aerospace Engineering.
Responsibility: by Ajay Shirolkar.

Abstract:

Abstract: Cardiovascular disease (CVD) is one of the largest epidemic in the world causing 800,000 annual deaths in the U.S alone and 15 million deaths worldwide. After a myocardial infarction, commonly known as a heart attack, the cells around the infarct area get deprived of oxygen and die resulting in scar tissue formation and subsequent arrhythmic beating of the heart. Due to the inability of cardiomyocytes to differentiate, the chances of recurrence of an infarction are tremendous. Research has shown that recurrence lead to death within 2 years in 10% of the cases and within 10 years in 50% of the cases. Therefore, an external structure is needed to support cardiomyocyte growth and bring the heart back to proper functioning. Current research shows that composite materials coupled with nanotechnology, a material where one of its dimension is less than or equal to 100nm, has very high potential in becoming a successful alternative treatment for end stage heart failure. The main goal of this research is to develop a composite material that will act as a scaffold to help externally cultured cardiomyocytes grow in the infarct area of the heart. The composite will consist of a poly-lactic co glycolic acid (PLGA) matrix, reinforced with carbon nanotubes. Prior research has been conducted with this same composite, however the significance of the composite developed in this research is that the nanotubes will be aligned with the help of an electro-magnetic field. This alignment is proposed to promote mechanical strength and significantly enhance proliferation and adhesion of the cardiomyocytes.

Reviews

User-contributed reviews
Retrieving GoodReads reviews...
Retrieving DOGObooks reviews...

Tags

Be the first.
Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Linked Data


Primary Entity

<http://www.worldcat.org/oclc/1083724395> # A nano-composite for cardiovascular tissue engineering
    a schema:Book, schema:CreativeWork, pto:Web_document, bgn:Thesis ;
    bgn:inSupportOf "" ;
    library:oclcnum "1083724395" ;
    library:placeOfPublication <http://id.loc.gov/vocabulary/countries/cau> ;
    schema:about <http://experiment.worldcat.org/entity/work/data/8891583327#Topic/nanocomposites_materials> ; # Nanocomposites (Materials)
    schema:about <http://experiment.worldcat.org/entity/work/data/8891583327#Topic/tissue_engineering> ; # Tissue engineering
    schema:about <http://experiment.worldcat.org/entity/work/data/8891583327#Topic/cardiovascular_system_diseases_treatment> ; # Cardiovascular system--Diseases--Treatment
    schema:about <http://experiment.worldcat.org/entity/work/data/8891583327#Topic/nanotechnology> ; # Nanotechnology
    schema:about <http://experiment.worldcat.org/entity/work/data/8891583327#Topic/heart_cells_growth> ; # Heart cells--Growth
    schema:author <http://experiment.worldcat.org/entity/work/data/8891583327#Person/shirolkar_ajay> ; # Ajay Shirolkar
    schema:datePublished "2018" ;
    schema:description "Abstract: Cardiovascular disease (CVD) is one of the largest epidemic in the world causing 800,000 annual deaths in the U.S alone and 15 million deaths worldwide. After a myocardial infarction, commonly known as a heart attack, the cells around the infarct area get deprived of oxygen and die resulting in scar tissue formation and subsequent arrhythmic beating of the heart. Due to the inability of cardiomyocytes to differentiate, the chances of recurrence of an infarction are tremendous. Research has shown that recurrence lead to death within 2 years in 10% of the cases and within 10 years in 50% of the cases. Therefore, an external structure is needed to support cardiomyocyte growth and bring the heart back to proper functioning. Current research shows that composite materials coupled with nanotechnology, a material where one of its dimension is less than or equal to 100nm, has very high potential in becoming a successful alternative treatment for end stage heart failure. The main goal of this research is to develop a composite material that will act as a scaffold to help externally cultured cardiomyocytes grow in the infarct area of the heart. The composite will consist of a poly-lactic co glycolic acid (PLGA) matrix, reinforced with carbon nanotubes. Prior research has been conducted with this same composite, however the significance of the composite developed in this research is that the nanotubes will be aligned with the help of an electro-magnetic field. This alignment is proposed to promote mechanical strength and significantly enhance proliferation and adhesion of the cardiomyocytes."@en ;
    schema:exampleOfWork <http://worldcat.org/entity/work/id/8891583327> ;
    schema:inLanguage "en" ;
    schema:isPartOf <http://experiment.worldcat.org/entity/work/data/8891583327#Series/master_s_thesis_collection_department_of_mechanical_and_aerospace_engineering> ; # Master's thesis collection, Department of Mechanical and Aerospace Engineering.
    schema:name "A nano-composite for cardiovascular tissue engineering"@en ;
    schema:productID "1083724395" ;
    schema:url <http://csulb.idm.oclc.org/login?url=https://search.proquest.com/docview/2133698332?accountid=10351> ;
    schema:workExample <http://worldcat.org/isbn/9780438633667> ;
    wdrs:describedby <http://www.worldcat.org/title/-/oclc/1083724395> ;
    .


Related Entities

<http://experiment.worldcat.org/entity/work/data/8891583327#Organization/california_state_university_long_beach> # California State University, Long Beach.
    a schema:Organization ;
    schema:name "California State University, Long Beach." ;
    .

<http://experiment.worldcat.org/entity/work/data/8891583327#Person/shirolkar_ajay> # Ajay Shirolkar
    a schema:Person ;
    schema:familyName "Shirolkar" ;
    schema:givenName "Ajay" ;
    schema:name "Ajay Shirolkar" ;
    .

<http://experiment.worldcat.org/entity/work/data/8891583327#Series/master_s_thesis_collection_department_of_mechanical_and_aerospace_engineering> # Master's thesis collection, Department of Mechanical and Aerospace Engineering.
    a bgn:PublicationSeries ;
    schema:creator <http://experiment.worldcat.org/entity/work/data/8891583327#Organization/california_state_university_long_beach> ; # California State University, Long Beach.
    schema:hasPart <http://www.worldcat.org/oclc/1083724395> ; # A nano-composite for cardiovascular tissue engineering
    schema:name "Master's thesis collection, Department of Mechanical and Aerospace Engineering." ;
    schema:name "[Master's thesis collection, Department of Mechanical and Aerospace Engineering]" ;
    .

<http://experiment.worldcat.org/entity/work/data/8891583327#Topic/cardiovascular_system_diseases_treatment> # Cardiovascular system--Diseases--Treatment
    a schema:Intangible ;
    schema:name "Cardiovascular system--Diseases--Treatment"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/8891583327#Topic/heart_cells_growth> # Heart cells--Growth
    a schema:Intangible ;
    schema:name "Heart cells--Growth"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/8891583327#Topic/nanocomposites_materials> # Nanocomposites (Materials)
    a schema:Intangible ;
    schema:name "Nanocomposites (Materials)"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/8891583327#Topic/tissue_engineering> # Tissue engineering
    a schema:Intangible ;
    schema:name "Tissue engineering"@en ;
    .

<http://worldcat.org/isbn/9780438633667>
    a schema:ProductModel ;
    schema:isbn "0438633660" ;
    schema:isbn "9780438633667" ;
    .


Content-negotiable representations

Close Window

Please sign in to WorldCat 

Don't have an account? You can easily create a free account.