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Nanoscale fabrication, optimization, scale-up and biological aspects of pharmaceutical nanotechnology

Author: Alexandru Mihai Grumezescu
Publisher: Kidlington, Oxford : William Andrew, an imprint of Elsevier, [2018] ©2018
Series: Pharmaceutical nanotechnology series.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Nanoscale Fabrication, Optimization, Scale-up and Biological Aspects of Pharmaceutical Nanotechnology focuses on the fabrication, optimization, scale-up and biological aspects of pharmaceutical nanotechnology. In particular, the following aspects of nanoparticle preparation methods are discussed: the need for less toxic reagents, simplification of the procedure to allow economic scale-up, and optimization to improve  Read more...
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Genre/Form: Electronic books
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Alexandru Mihai Grumezescu
ISBN: 9780128136300 0128136308
OCLC Number: 1013889108
Description: 1 online resource : illustrations.
Contents: 1. Fabrication of polymeric core-shell nanostructures --
2. Emulsification-diffusion method to obtain polymeric nanoparticles: two decades of research --
3. Tools and Techniques for the optimized synthesis, reproducibility and scale up of desired nanostructures from plant derived material and their role in pharmaceutical properties --
4. Scale up of biopharmaceuticals production --
5. Physicochemical and morphological characterization of pharmaceutical nanocarriers and mathematical modelling of drug encapsulation/release mass transfer processes --
6. Biopharmaceutics and pharmacokinetics of multifunctional nanoparticles --
7. Technological delivery systems to improve biopharmaceutical properties --
8. From physicochemically stable nanocarriers to targeted drug delivery: in-vivo pharmacokinetic, pharmacodynamic and biodistribution studies --
9. Sterile dosage forms loaded nanosystems for parenteral, nasal, pulmonary and ocular administration --
10. Quantitative Characterization of Targeted Nanoparticulate Formulations for Prediction of Clinical Efficacy --
11. Analytical tools for reliable in vitro and in vivo performance testing of drug nanocrystals --
12. Application of one-step affinity purification of drug-binding proteins with practical magnetic nanoparticles to drug discovery --
13. Molecularly Imprinted Polymers as Separation Tools --
14. Detection of DNA damage induced by nanomaterials --
15. Pharmacological usage of an enzyme inhibitor --
a selective inhibitor of 3-mercaptopyruvate sulfurtransferase reaction intermediate to control generation of polysulfide --
16. Regulatory Consideration in Nanotechnology Based Drug Products.
Series Title: Pharmaceutical nanotechnology series.
Responsibility: edited by Alexan Mihai Grumezescu.

Abstract:

Nanoscale Fabrication, Optimization, Scale-up and Biological Aspects of Pharmaceutical Nanotechnology focuses on the fabrication, optimization, scale-up and biological aspects of pharmaceutical nanotechnology. In particular, the following aspects of nanoparticle preparation methods are discussed: the need for less toxic reagents, simplification of the procedure to allow economic scale-up, and optimization to improve yield and entrapment efficiency. Written by a diverse range of international researchers, the chapters examine characterization and manufacturing of nanomaterials for pharmaceutical applications. Regulatory and policy aspects are also discussed. This book is a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about how nanomaterials can best be utilized.

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