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Natural products and drug discovery : an integrated approach

Author: Subhash C Mandal; Vivekananda Mandal; Tetsuya Konishi
Publisher: Amsterdam, Netherlands : Elsevier, [2018]
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Natural Products and Drug Discovery: An Integrated Approach provides an applied overview of the field, from traditional medicinal targets, to cutting-edge molecular techniques. Natural products have always been of key importance to drug discovery, but as modern techniques and technologies have allowed researchers to identify, isolate, extract and synthesize their active compounds in new ways, they are once again  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
(OCoLC)1001456634
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Subhash C Mandal; Vivekananda Mandal; Tetsuya Konishi
ISBN: 9780081021040 0081021046
OCLC Number: 1023628137
Notes: Includes indexes.
Description: 1 online resource
Contents: Front Cover; Natural Products and Drug Discovery; Natural Products and Drug Discovery; Copyright; Contents; List of Contributors; Foreword; Preface; I --
Traditional Medicine and Drug Discovery; 1 --
Drug Discovery From Ayurveda: Mode of Approach and Applications; 1. AYUSH AND AYURVEDA; 2. CHRONOLOGICAL GENESIS OF AYURVEDIC DRUGS FOR THERAPEUTIC APPLICATION; 3. FUNDAMENTAL PRINCIPLES OF PERSONALIZED MEDICINE, GENETIC STUDY, AND APPLIED ASPECTS OF AYURVEDIC PHARMACODYNAMICS; 4. CLASSIFICATION OF AYURVEDIC THERAPEUTICS; 4.1 Ayurvedic Treatment for the Promotion of Health 4.2 Treatment for the Prevention of Disease4.3 Curative Management in Ayurveda; 4.3.1 Curative Management With Plant Drugs; 4.3.2 Metals and Minerals for Curative Management; 4.3.3 Animal Products for Curative Management; 5. SCIENTIFIC RESEARCH OF AYURVEDA FOR DRUG DEVELOPMENT FROM PLANT SOURCES; 5.1 Rasayana Therapy; 5.2 Diabetes Mellitus; 5.3 Wound-Healing Drugs; 5.4 Learning, Memory, and Cognitive Disorders; 6. SCIENTIFIC RESEARCH OF AYURVEDA FOR DRUG DEVELOPMENT FROM METALS AND MINERALS; 6.1 Drugs From Zinc: Jasada Bhasma; 6.2 Iron Therapy in Ayurveda; 6.3 Gold Therapy in Ayurveda 6.4 Shilajit: A Unique Molecule of Ayurveda7. RECOMMENDATION; REFERENCES; 2 --
Traditional and Folk Medicine as a Target for Drug Discovery; 1. INTRODUCTION; 2. DIFFERENT TRADITIONAL AND FOLK MEDICINES; 2.1 Ayurveda; 2.2 Maibaron; 2.3 Traditional Chinese Medicine; 2.4 Traditional Korean Medicine; 2.5 African Medicine (Muti in South and Ifa in West); 2.6 Iranian Medicine; 3. TAXOL AS A LEAD TO CANCER DRUG DISCOVERY; 4. DEMAND FOR DRUGS FOR LIVER DISORDERS (HEPATIC DISEASE); 5. DEMAND FOR DRUGS FOR DENGUE; 5.1 Targeting â#x80;#x94;and Controlling the Virus; 5.1.1 Plant Sources; 5.1.2 Compound Sources 5.1.3 Mushroom Sources5.1.4 Formulations; 5.2 Targeting â#x80;#x94;and Controlling the Vector Mosquito; 6. CONCLUSION; REFERENCES; 3 --
Bioactivity-Guided Phytofractions: An Emerging Natural Drug Discovery Tool for Safe and Effective Disease Manag ... ; 1. INTRODUCTION; 2. WHY DO BIOACTIVITY-GUIDED PHYTOFRACTIONS EXHIBIT PROMISING ALLEVIATION AGAINST DISEASE MODELS; 3. SEPARATION, CHARACTERIZATION, AND STANDARDIZATION OF TARGET DISEASE-SPECIFIC BIOACTIVITY-GUIDED FRACTIONS; 4. SIGNIFICANCE AND UTILITY OF TARGET-ORIENTED, DISEASE-SPECIFIC, BIOACTIVITY-GUIDED PHYTOFRACTIONS 5. EXPERIMENTAL EVIDENCE IN FAVOR OF BIOASSAY-GUIDED PHYTOFRACTION AS A THERAPEUTIC TOOL6. DISCUSSION AND CONCLUSION; ACKNOWLEDGMENTS; REFERENCES; 4 --
Development of Chinese Herbal Health Products for the Prevention of Aging-Associated Diseases; 1. MITOCHONDRIAL DYSFUNCTION IN AGING-ASSOCIATED DISEASES; 1.1 Cardiovascular Diseases; 1.2 Neurodegenerative Diseases; 1.3 Osteoporosis; 1.4 Dysregulation of Immune Function; 2. CONCEPTUAL BASIS OF PREVENTIVE HEALTH IN CHINESE MEDICINE; 2.1 Yin-Yang Theory; 2.2 Qi and Body Function
Responsibility: editors, Subhash C. Mandal, Vivekananda Mandal, Tetsuya Konishi.

Abstract:

Natural Products and Drug Discovery: An Integrated Approach provides an applied overview of the field, from traditional medicinal targets, to cutting-edge molecular techniques. Natural products have always been of key importance to drug discovery, but as modern techniques and technologies have allowed researchers to identify, isolate, extract and synthesize their active compounds in new ways, they are once again coming to the forefront of drug discovery. Combining the potential of traditional medicine with the refinement of modern chemical technology, the use of natural products as the basis for drugs can help in the development of more environmentally sound, economical, and effective drug discovery processes. Natural Products & Drug Discovery: An Integrated Approach reflects on the current changes in this field, giving context to the current shift and using supportive case studies to highlight the challenges and successes faced by researchers in integrating traditional medicinal sources with modern chemical technologies. It therefore acts as a useful reference to medicinal chemists, phytochemists, biochemists, pharma R & D professionals, and drug discovery students and researchers.

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