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Neurobiology of depression : road to novel therapeutics

Author: João Quevedo; André F Carvalho; Carlos A Zarate, Jr.
Publisher: London, United Kingdom ; San Diego, CA : Academic Press, an imprint of Elsevier, [2019]
Edition/Format:   eBook : Document : EnglishView all editions and formats
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Genre/Form: Electronic books
Additional Physical Format: Print version:
NEUROBIOLOGY OF DEPRESSION.
[Place of publication not identified], ELSEVIER ACADEMIC Press, 2019
(OCoLC)1047822936
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: João Quevedo; André F Carvalho; Carlos A Zarate, Jr.
ISBN: 9780128133347 0128133341
OCLC Number: 1081173641
Description: 1 online resource.
Contents: Front Cover; Neurobiology of Depression: Road to Novel Therapeutics; Copyright; Contents; Contributors; Chapter 1: The Classification of Depression: Embracing Phenotypic Heterogeneity in the Era of the RDoC; Funding; Conflict of Interest; Acknowledgments; References; Chapter 2: The Role of Environmental and Psychosocial Factors in Depression; Introduction; Some Consideration of ``Depression;́́ Depressogenic Factors; Impact of Cognitive Style; Mechanisms Linking Psychosocial Stressors With Depression: The Centrality of Self-Esteem; Depressogenic Stressors; Depression Versus Grief The Role of PersonalityKeys and Locks: ``Swiss Cheese ́́and a Lacunae Self-Esteem; Conclusions; Acknowledgments; References; Chapter 3: Gene-Environment Interactions and Epigenetic Mechanisms in Depression; Introduction; Gene x Environment Effects (Candidate Genes); Candidate Genes Within the Serotonergic System; Serotonin Transporter Polymorphism (SLC6A4); GxE Effects in BDNF Function in MDD; GxE Effects in HPA Dysregulation in MDD; GxE Effects: FKBP5 Gene; GxE Effects: CRHR1; Epigenetic Mechanisms Modulating Environmental Effects Epigenetic Mechanisms Modulating Serotonin Transporter Gene ExpressionEpigenetic Mechanisms Modulating BDNF Gene Expression; Epigenetic Mechanisms in the Regulation of Genes Within the HPA Axis; Genome-Wide GenexEnvironment Effects; Discussion; References; Chapter 4: Pathophysiology of Cognitive Impairment in Depression; Executive Functioning; Working Memory; Memory; References; Further Reading; Chapter 5: Anhedonia in Depression: Mechanisms, Assessment, and Therapeutics; Introduction; Anhedonia: A Brief Historical Context; Anhedonia and Vulnerability to Major Depression Neural Mechanisms of Anhedonia and DepressionMultifactorial Influences on Striatal Responding and Mood; Environment; Assessment; Therapeutics; Conclusions; Conflict of Interest; Acknowledgments; References; Chapter 6: The Neurotrophic Hypothesis of Depression Revisited: New Insights and Therapeutic Implications; Introduction; Brain-Derived Neurotrophic Factor (BDNF); Role of BDNF in the Effects of Chronic Stress; Regulation of BDNF by Stress; Contribution of BDNF to Stress-Evoked Cytoarchitectural Changes; Contribution of BDNF to Stress-Induced Depressive-like Behavior Role of BDNF in Antidepressant ActionRegulation of BDNF by Antidepressants; Contribution of BDNF to Antidepressant-Evoked Cytoarchitectural Changes; Influence of BDNF Signaling on Antidepressant-Mediated Behaviors; Clinical Studies; Regulation of BDNF in Depressed Patients; Regulation of BDNF Expression in Response to Antidepressant Treatment; BDNF Polymorphisms; Summary; References; Chapter 7: The Monoamine Hypothesis of Depression Revisited: Could It Mechanistically Novel Antidepressant Strategies?; The Monoamine Hypothesis; Serotonin-Noradrenaline; Dopamine; Withdrawal from Antidepressants
Responsibility: edited by João Quevedo, André F. Carvalho, Carlos A. Zarate.

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