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Neuroimmune diseases : from cells to the living brain

Author: Hiroshi Mitoma; Mario Manto
Publisher: Cham, Switzerland : Springer, [2019]
Series: Contemporary clinical neuroscience.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
A translational overview of neuroimmune diseases for neuroscientists and clinicians that clarifies the pathological mechanisms underlying neuroimmune diseases and builds a comprehensive bridge between the latest research findings and their clinical implications in daily practice. The material is presented in two steps. The first section comprises a review of the pathogenic actions of immune cells in brain diseases.  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Mitoma, Hiroshi.
Neuroimmune Diseases : From Cells to the Living Brain.
Cham : Springer, ©2019
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Hiroshi Mitoma; Mario Manto
ISBN: 9783030195151 3030195155 9783030195168 3030195163 9783030195175 3030195171
OCLC Number: 1112424985
Notes: Long-Term Neurological and Systemic Complications in SCI Patients
Description: 1 online resource (819 pages)
Contents: Intro; Contents; Part I: Fundamental Mechanisms and General Principles; Overview of Mechanisms Underlying Neuroimmune Diseases; Introduction; Divergence and Convergence in Neuroimmune Diseases; Blood-Brain Barrier and Blood-Nerve Barrier; Local Immune Cascades; Therapeutic Strategies of Neuroimmune Diseases; Clinical Features of Neuroimmune Diseases; Lesion-Dependent Neurological Symptoms; Association of Other Neuroimmune Diseases; Multifocal Lesions; Divergent Immune Mechanisms; Fundamental Pathogenic Factors Determining Clinical Profiles; Autoantibody- and Cell-Mediated Immune Mechanisms Neuroinflammatory CascadesTriggering of Autoimmunity: Parainfectious and Paraneoplastic Conditions; Cross Talk Between the Immune System and Degenerative or Psychiatric Diseases; Mechanisms of Neuroimmune Diseases; Mechanisms of T Cell-Mediated Neuroinflammation and Autoimmunity; Mechanisms of Antibody-Mediated Neuroinflammation and Autoimmunity; Role of Infections in the Neuroinflammation and Autoimmunity; Neuroimmune Mechanisms in Paraneoplastic Diseases; Neuroimmune Mechanisms in Vascular Inflammatory Diseases; Neuroimmune Mechanisms in Neurodegenerative Diseases Neuroimmune Mechanisms in Neuropsychiatric DiseasesFuture Perspective; References; Roles of Effector T Cells in Neurological Autoimmunity; Introduction; Dysregulation of the Th1/Th2 Balance in MS; Th17 Cells in MS/EAE; CD8 T Cells in MS/EAE; Possible Therapeutic Targets for Neurodegeneration and Demyelination in MS and EAE; Conclusion; References; The Role of Th17 Cells in Immunopathogenesis of Neuroinflammatory Disorders; Introduction; The Role of Th17 Cells in Immunopathogenesis of Multiple Sclerosis; Roles of Th1 and Th17 Cells in Pathogenesis of Multiple Sclerosis Actions of Divergent Pro-Inflammatory CytokinesTh17 Cell Plasticity; Multiple Actions of IL-17; Th17-Related Inflammation and the Neuronal Apoptosis; Multiple Actions of IL-22, IL-23, and GM-CSF; Open Problems and Therapeutic Applications; The Role of Th17 Cells in Immunopathogenesis of Alzheimer Disease; Link Between Immune System and Neurodegeneration; Th17-Mediated Mechanisms in Alzheimer Disease; The Role of Th17 Cells in Immunopathogenesis of Parkinson Disease; Immune-Mediated Mechanisms in Parkinson Disease; Th17 Cell Role in Parkinson Disease The Role of Th17 Cells in Immunopathogenesis of Schizophrenia DiseaseImmunopathology of Schizophrenia Disease; Immunopathology of Schizophrenia from Th17 Cell Viewpoint; Conclusion; References; Significance of Autoantibodies; Introduction; Theme A: Causes of Antibody Development; Paraneoplastic Neurologic Disorders (PNS); Clinical Example; Anti-Yo Antibody-Associated Paraneoplastic Cerebellar Degenerations; Infection; Clinical Example; Herpes Simplex Virus-1 (HSV-1) Encephalitis and NMDAR Encephalitis; Injuries to the CNS; Clinical Example
Series Title: Contemporary clinical neuroscience.
Responsibility: Hiroshi Mitoma, Mario Manto, editors.

Abstract:

A translational overview of neuroimmune diseases for neuroscientists and clinicians that clarifies the pathological mechanisms underlying neuroimmune diseases and builds a comprehensive bridge  Read more...

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