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New bioactive natural products from Coprinus micaceus
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New bioactive natural products from Coprinus micaceus

Author: Shamsulhaq Zahid Affiliation: Department of Chemistry, The University of Winnipeg, 515 Portage Avenue, Winnipeg, Manitoba, Canada R3B 2E9Chibuike C Udenigwe Affiliation: Department of Chemistry, The University of Winnipeg, 515 Portage Avenue, Winnipeg, Manitoba, Canada R3B 2E9Athar Ata Affiliation: Department of Chemistry, The University of Winnipeg, 515 Portage Avenue, Winnipeg, Manitoba, Canada R3B 2E9Michael O Eze Affiliation: Department of Chemistry, The University of Winnipeg, 515 Portage Avenue, Winnipeg, Manitoba, Canada R3B 2E9Edward P Segstro Affiliation: Department of Chemistry, The University of Winnipeg, 515 Portage Avenue, Winnipeg, Manitoba, Canada R3B 2E9All authors
Edition/Format: Article Article : English
Publication:Natural Product Research, v20 n14 (December 2006): 1283-1289
Other Databases: WorldCatWorldCat
Summary:
Chemical studies on the crude methanolic extract of Coprinus micaceus, collected from the Canadian Prairie region, have resulted in the isolation of two new natural products, micaceol (1), a sterol and (Z,Z)-4-oxo-2,5-hetpadienedioic acid (2). Compound 2 was isolated for the first time as a natural product. Structures of these new compounds were established with the aid of extensive NMR spectroscopic studies.  Read more...
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Document Type: Article
All Authors / Contributors: Shamsulhaq Zahid Affiliation: Department of Chemistry, The University of Winnipeg, 515 Portage Avenue, Winnipeg, Manitoba, Canada R3B 2E9; Chibuike C Udenigwe Affiliation: Department of Chemistry, The University of Winnipeg, 515 Portage Avenue, Winnipeg, Manitoba, Canada R3B 2E9; Athar Ata Affiliation: Department of Chemistry, The University of Winnipeg, 515 Portage Avenue, Winnipeg, Manitoba, Canada R3B 2E9; Michael O Eze Affiliation: Department of Chemistry, The University of Winnipeg, 515 Portage Avenue, Winnipeg, Manitoba, Canada R3B 2E9; Edward P Segstro Affiliation: Department of Chemistry, The University of Winnipeg, 515 Portage Avenue, Winnipeg, Manitoba, Canada R3B 2E9; Paul Holloway Affiliation: Department of Biology, The University of Winnipeg, 515 Portage Avenue, Winnipeg, Manitoba, Canada R3B 2E9
ISSN:1478-6419
Language Note: English
Unique Identifier: 4893815006
Awards:

Abstract:

Chemical studies on the crude methanolic extract of Coprinus micaceus, collected from the Canadian Prairie region, have resulted in the isolation of two new natural products, micaceol (1), a sterol and (Z,Z)-4-oxo-2,5-hetpadienedioic acid (2). Compound 2 was isolated for the first time as a natural product. Structures of these new compounds were established with the aid of extensive NMR spectroscopic studies. Compound 1 has shown anti-bacterial activity against Corynebacterium xerosis and Staphylococcus aureus, whereas compound 2 exhibited glutathione S-transferase inhibition.

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