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New Methods for the Study of Biomolecular Complexes

Author: Werner Ens; Kenneth G Standing; Igor V Chernushevich
Publisher: Dordrecht : Springer Netherlands, 1998.
Series: NATO ASI series., Series C,, Mathematical and physical sciences ;, 510.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
The particular focus of the present book is the application of mass spectrometry to the investigation and characterization of noncovalent biomolecular complexes. Both electrospray ionization and matrix-assisted laser desorption/ionization methods are discussed. Electrospray ionization mass spectrometry is particularly effective for studying noncovalent interactions because the sample is introduced from an  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Werner Ens; Kenneth G Standing; Igor V Chernushevich
ISBN: 9789401590464 940159046X
OCLC Number: 851379419
Language Note: English.
Description: 1 online resource (xi, 354 pages).
Contents: A General Approach to Deciphering how Proteins Work Using Synthetic Chemistry and Mass Spectrometry --
Approaches to the Characterisation of Tertiary and Supramolecular Protein Structures by Combination of Protein Chemistry and Mass Spectrometry --
Protein-Ligand Binding Studied by Amide Hydrogen Exchange and Mass Spectrometry --
Structural Studies of Protein-Protein Interactions Using Proteolytic Footprinting and MALDI/MS --
Investigation of the Effect of Protein Oxidation upon the Lipid-Binding Activity of the Cerebroside-Sulfate Activator Protein (Saposin B) --
The Use of Chemical Ligation for Investigation of the Structure of Duplexes Formed by Linear and Circular Oligonucleotides --
Studying Noncovalent Protein-RNA Interactions and Drug Binding by Electrospray Ionization Mass Spectrometry --
Measurement of Noncovalent Complexes with High m/z by Electrospray Time-of-Flight Mass Spectrometry --
Non-Covalent Complexes of Oligonucleotides Observed Using Electrospray Ionization Mass Spectrometry --
Observations of Non-Covalent Complexes of Citrate Synthase and NADH by ESI/TOF Mass Spectrometry --
Gas-Phase Dissociation Energies of Hydrogen-Bonded Complexes in a Quadrupole Ion Trap Mass Spectrometer --
Electrospray Ionization FTICR Spectrometry of Metalloproteins --
On the Determination of the Ion Internal Energy in an Electrospray Source --
Observation of Protein Heptamer Formation for Chemically Ligated Early Pregnancy Factor --
Matrix-Assisted Laser Desorption Ionization of Non-Covalent Complexes --
Characterization of Tertiary Structure States and Specific Noncovalent Complexes of Proteins by UV-Matrix-Assisted Laser-Desorption/Ionization Mass Spectrometry --
Non-Covalent Hetero- and Homo-Oligomeric Protein Complexes Reassociate Differentially during MALDI-MS Analysis --
The Detection of Non-Covalent Interactions in Nucleic Acids Using MALDI --
Mass Spectrometric Methods for Biomolecular Characterization --
X-Ray Crystallographic and Mass Spectrometric Structure Determination and Functional Characterisation of Succinylated Porin from Rhodobacter Capsulatus: Implications for Ion Selectivity and Single-Channel Conductance --
Structural Relation of Peridinin-Chlorophyll A-Protein (PCP) and Proteins with Globin-like Fold --
A Testable Hypothesis for its Folding and Assembly Pathway --
The Development of NMR Methods to Study Protein Structure and Dynamics --
BIAcore Technology --
A Marriage Partner to Mass Spectrometry? --
Biospecific Interactions Measured by Capillary Electrophoresis --
Application of Neutron Scattering Techniques to Problems of Biological Relevance --
List of Participants.
Series Title: NATO ASI series., Series C,, Mathematical and physical sciences ;, 510.
Other Titles: Proceedings of the NATO Advanced Research Workshop on New Methods for the Study of Molecular Aggregates, The Lodge at Kananaskis Village, Alberta, Canada, 16-20 June 1996
Responsibility: edited by Werner Ens, Kenneth G. Standing, Igor V. Chernushevich.

Abstract:

Proceedings of the NATO Advanced Research Workshop on New Methods for the Study of Molecular Aggregates, The Lodge at Kananaskis Village, Alberta, Canada, 16-20 June 1996  Read more...

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