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Next generation sequencing in cancer research. Volume 1, Decoding the cancer genome

Author: Wei Wu; Hani Choudhry
Publisher: New York, NY : Springer, 2013.
Series: 2012-2013 Springer E-Books - Biomedical & Life Sciences.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Next Generation Sequencing (NGS) technology has placed important milestones in the life science and changed the direction in biomedical science inclucing cancer. Scientists around the world are attempting to find the root cause of cancer and they are looking for more direct and effective means to cure cancer. This journey to conquer cancer is more optimistic now with the unfolding of the cancer genome. This book  Read more...
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Details

Genre/Form: Electronic books
Additional Physical Format: Printed edition:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Wei Wu; Hani Choudhry
ISBN: 9781461476450 1461476453 1461476445 9781461476443
OCLC Number: 856631749
Language Note: English.
Notes: Includes index.
Description: 1 online resource (xxiii, 383 pages) : illustrations
Contents: Introduction: next generation sequencing technology and cancer research --
The majority of total nuclear-encoded non-ribosomal RNA in a human cell is dark matter unannotated RNA --
Total RNA-seq of breast cancer in hypoxia --
Altered antisense-to-sense transcript ratios in breast cancer --
Identification of piRNAs in Hela cells by massive parallel sequencing --
Discovery of new microRNAs by small RNAome deep sequencing in childhood acute lymphoblastic leukemia --
Whole-Exome Sequencing Identifies FAM20A Mutations as a Cause of Amelogenesis Imperfecta and Gingival Hyperplasia Syndrome --
Whole-exome sequencing in CIC and IDH1/2 contributing to human oligodendroglioma --
Genetic and structural variation in the gastric cancer kinome revealed through targeted deep sequencing --
Tumour evolution inferred by single-cell sequencing --
Characterization of the single-cell transcriptional landscape by highly multiplex RNA-seq --
Tracing the derivation of embryonic stem cells from the inner cell mass by single-cell RNASeq analysis --
Whole genome DNA methylation analysis based on high throughput sequencing technology --
Comparative methylome analysis of benign and malignant peripheral nerve sheath tumors --
High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq --
MicroRNA transfection and AGO-bound CLIP-seq data sets reveal distinct determinants of miRNA action --
Genome-wide identification of polycomb-associated RNAs by RIP-seq --
Single-molecule sequencing: sequence methods to enable accurate quantisation --
Metabolic labeling of RNA uncovers principles of RNA production and degradation dynamics in mammalian cells --
Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA --
The genome information process for cancer research: the challenge and perspective.
Series Title: 2012-2013 Springer E-Books - Biomedical & Life Sciences.
Other Titles: Decoding the cancer genome
Responsibility: Wei Wu, Hani Choudhry, Editors.

Abstract:

This book offers an interdisciplinary perspective on applying Next Generation Sequencing (NGS) technology to cancer research, surveying the foundations of the technology and its implications in  Read more...

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Primary Entity<\/h3>\n
<http:\/\/www.worldcat.org\/oclc\/856631749<\/a>> # Next generation sequencing in cancer research. 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# Biomedicine general<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/dewey.info\/class\/616.994\/e23\/<\/a>> ;\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/1405305648#Topic\/biomedische_wetenschappen<\/a>> ; # biomedische wetenschappen<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/1405305648#Topic\/biomedicine<\/a>> ; # biomedicine<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/1405305648#Topic\/nucleotide_sequence<\/a>> ; # Nucleotide sequence<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/1405305648#Topic\/medical_clinical_medicine<\/a>> ; # MEDICAL--Clinical Medicine<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/1405305648#Topic\/medical_diseases<\/a>> ; # MEDICAL--Diseases<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/1405305648#Topic\/humane_genetica<\/a>> ; # humane genetica<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/1405305648#Topic\/cancer_genetic_aspects<\/a>> ; # Cancer--Genetic aspects<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/1405305648#Topic\/genes_neoplasm<\/a>> ; # Genes, Neoplasm<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/1405305648#Topic\/neoplasms<\/a>> ; # neoplasms<\/span>\n\u00A0\u00A0\u00A0\nschema:alternateName<\/a> \"Decoding the cancer genome<\/span>\" ;\u00A0\u00A0\u00A0\nschema:bookFormat<\/a> schema:EBook<\/a> ;\u00A0\u00A0\u00A0\nschema:datePublished<\/a> \"2013<\/span>\" ;\u00A0\u00A0\u00A0\nschema:description<\/a> \"Introduction: next generation sequencing technology and cancer research -- The majority of total nuclear-encoded non-ribosomal RNA in a human cell is dark matter unannotated RNA -- Total RNA-seq of breast cancer in hypoxia -- Altered antisense-to-sense transcript ratios in breast cancer -- Identification of piRNAs in Hela cells by massive parallel sequencing -- Discovery of new microRNAs by small RNAome deep sequencing in childhood acute lymphoblastic leukemia -- Whole-Exome Sequencing Identifies FAM20A Mutations as a Cause of Amelogenesis Imperfecta and Gingival Hyperplasia Syndrome -- Whole-exome sequencing in CIC and IDH1\/2 contributing to human oligodendroglioma -- Genetic and structural variation in the gastric cancer kinome revealed through targeted deep sequencing -- Tumour evolution inferred by single-cell sequencing -- Characterization of the single-cell transcriptional landscape by highly multiplex RNA-seq -- Tracing the derivation of embryonic stem cells from the inner cell mass by single-cell RNASeq analysis -- Whole genome DNA methylation analysis based on high throughput sequencing technology -- Comparative methylome analysis of benign and malignant peripheral nerve sheath tumors -- High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq -- MicroRNA transfection and AGO-bound CLIP-seq data sets reveal distinct determinants of miRNA action -- Genome-wide identification of polycomb-associated RNAs by RIP-seq -- Single-molecule sequencing: sequence methods to enable accurate quantisation -- Metabolic labeling of RNA uncovers principles of RNA production and degradation dynamics in mammalian cells -- Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA -- The genome information process for cancer research: the challenge and perspective.<\/span>\" ;\u00A0\u00A0\u00A0\nschema:description<\/a> \"Next Generation Sequencing (NGS) technology has placed important milestones in the life science and changed the direction in biomedical science inclucing cancer. Scientists around the world are attempting to find the root cause of cancer and they are looking for more direct and effective means to cure cancer. This journey to conquer cancer is more optimistic now with the unfolding of the cancer genome. This book focuses on the application of various NGS in the frontier cancer genome research. The 18 chapters in this volume have been written by scientists with many outstanding contributions in their area and the join effort has created comprehensive insightful view on (1) Overview of next generation sequencing technology in cancer genome research (2) Genome regulation and targeted sequencing in cancer (3) RNA transcriptome (coding and non-coding) in cancer genome (4)The challenges of computational biology for cancer genome study. This book is a state-of-the-art reference to all scientific researchers and onologists who are interested in the understanding of the cancer initiatome at whole genome scale and to those are keen to translate the \'base pairs to bedside\' for better management of cancer patients in the era of personalized medicine.<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\nschema:editor<\/a> <http:\/\/viaf.org\/viaf\/306383152<\/a>> ; # Hani Choudhry<\/span>\n\u00A0\u00A0\u00A0\nschema:editor<\/a> <http:\/\/viaf.org\/viaf\/160079048<\/a>> ; # Wei Wu<\/span>\n\u00A0\u00A0\u00A0\nschema:exampleOfWork<\/a> <http:\/\/worldcat.org\/entity\/work\/id\/1405305648<\/a>> ;\u00A0\u00A0\u00A0\nschema:genre<\/a> \"Electronic books<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\nschema:inLanguage<\/a> \"en<\/span>\" ;\u00A0\u00A0\u00A0\nschema:isPartOf<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/1405305648#Series\/2012_2013_springer_e_books_biomedical_&_life_sciences<\/a>> ; # 2012-2013 Springer E-Books - Biomedical & Life Sciences.<\/span>\n\u00A0\u00A0\u00A0\nschema:isSimilarTo<\/a> <http:\/\/worldcat.org\/entity\/work\/data\/1405305648#CreativeWork\/<\/a>> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Next generation sequencing in cancer research. 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<http:\/\/experiment.worldcat.org\/entity\/work\/data\/1405305648#Series\/2012_2013_springer_e_books_biomedical_&_life_sciences<\/a>> # 2012-2013 Springer E-Books - Biomedical & Life Sciences.<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nbgn:PublicationSeries<\/a> ;\u00A0\u00A0\u00A0\nschema:hasPart<\/a> <http:\/\/www.worldcat.org\/oclc\/856631749<\/a>> ; # Next generation sequencing in cancer research. Volume 1, Decoding the cancer genome<\/span>\n\u00A0\u00A0\u00A0\nschema:name<\/a> \"2012-2013 Springer E-Books - Biomedical & Life Sciences.<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
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<http:\/\/experiment.worldcat.org\/entity\/work\/data\/1405305648#Topic\/biomedicine<\/a>> # biomedicine<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"biomedicine<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Biomedicine<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/1405305648#Topic\/biomedicine_general<\/a>> # Biomedicine general<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Biomedicine general<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/1405305648#Topic\/biomedische_wetenschappen<\/a>> # biomedische wetenschappen<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"biomedische wetenschappen<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/1405305648#Topic\/cancer_genes<\/a>> # Cancer genes<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Cancer genes<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/1405305648#Topic\/cancer_genetic_aspects<\/a>> # Cancer--Genetic aspects<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Cancer--Genetic aspects<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/1405305648#Topic\/cancer_research<\/a>> # Cancer Research<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Cancer Research<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/1405305648#Topic\/geneeskunde_algemeen<\/a>> # Geneeskunde (algemeen)<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Geneeskunde (algemeen)<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/1405305648#Topic\/genes_neoplasm<\/a>> # Genes, Neoplasm<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Genes, Neoplasm<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/1405305648#Topic\/health_&_fitness_diseases_general<\/a>> # HEALTH & FITNESS--Diseases--General<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"HEALTH & FITNESS--Diseases--General<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/1405305648#Topic\/human_genetics<\/a>> # human genetics<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"human genetics<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Human Genetics<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/1405305648#Topic\/humane_genetica<\/a>> # humane genetica<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"humane genetica<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/1405305648#Topic\/medical_clinical_medicine<\/a>> # MEDICAL--Clinical Medicine<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"MEDICAL--Clinical Medicine<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/1405305648#Topic\/medical_diseases<\/a>> # MEDICAL--Diseases<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"MEDICAL--Diseases<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/1405305648#Topic\/medical_evidence_based_medicine<\/a>> # MEDICAL--Evidence-Based Medicine<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"MEDICAL--Evidence-Based Medicine<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/1405305648#Topic\/medical_internal_medicine<\/a>> # MEDICAL--Internal Medicine<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"MEDICAL--Internal Medicine<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/1405305648#Topic\/medicine_general<\/a>> # Medicine (General)<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Medicine (General)<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/1405305648#Topic\/neoplasms<\/a>> # neoplasms<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"neoplasms<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/1405305648#Topic\/nucleotide_sequence<\/a>> # Nucleotide sequence<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Nucleotide sequence<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/id.loc.gov\/authorities\/subjects\/sh85019509<\/a>> # Cancer--Genetic aspects<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Cancer--Genetic aspects<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/id.loc.gov\/vocabulary\/countries\/nyu<\/a>>\u00A0\u00A0\u00A0\u00A0a \nschema:Place<\/a> ;\u00A0\u00A0\u00A0\ndcterms:identifier<\/a> \"nyu<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/libproxy.dundee.ac.uk\/login?url=http:\/\/dx.doi.org\/10.1007\/978-1-4614-7645-0<\/a>>\u00A0\u00A0\u00A0\nrdfs:comment<\/a> \"An electronic book accessible through the World Wide Web; click to view.<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/viaf.org\/viaf\/160079048<\/a>> # Wei Wu<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Person<\/a> ;\u00A0\u00A0\u00A0\nschema:familyName<\/a> \"Wu<\/span>\" ;\u00A0\u00A0\u00A0\nschema:givenName<\/a> \"Wei<\/span>\" ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Wei Wu<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/viaf.org\/viaf\/306383152<\/a>> # Hani Choudhry<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Person<\/a> ;\u00A0\u00A0\u00A0\nschema:familyName<\/a> \"Choudhry<\/span>\" ;\u00A0\u00A0\u00A0\nschema:givenName<\/a> \"Hani<\/span>\" ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Hani Choudhry<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/worldcat.org\/entity\/work\/data\/1405305648#CreativeWork\/<\/a>>\u00A0\u00A0\u00A0\u00A0a \nschema:CreativeWork<\/a> ;\u00A0\u00A0\u00A0\nschema:description<\/a> \"Printed edition:<\/span>\" ;\u00A0\u00A0\u00A0\nschema:isSimilarTo<\/a> <http:\/\/www.worldcat.org\/oclc\/856631749<\/a>> ; # Next generation sequencing in cancer research. Volume 1, Decoding the cancer genome<\/span>\n\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/worldcat.org\/isbn\/9781461476443<\/a>>\u00A0\u00A0\u00A0\u00A0a \nschema:ProductModel<\/a> ;\u00A0\u00A0\u00A0\nschema:isbn<\/a> \"1461476445<\/span>\" ;\u00A0\u00A0\u00A0\nschema:isbn<\/a> \"9781461476443<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/worldcat.org\/isbn\/9781461476450<\/a>>\u00A0\u00A0\u00A0\u00A0a \nschema:ProductModel<\/a> ;\u00A0\u00A0\u00A0\nschema:isbn<\/a> \"1461476453<\/span>\" ;\u00A0\u00A0\u00A0\nschema:isbn<\/a> \"9781461476450<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/www.worldcat.org\/title\/-\/oclc\/856631749<\/a>>\u00A0\u00A0\u00A0\u00A0a \ngenont:InformationResource<\/a>, genont:ContentTypeGenericResource<\/a> ;\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/www.worldcat.org\/oclc\/856631749<\/a>> ; # Next generation sequencing in cancer research. Volume 1, Decoding the cancer genome<\/span>\n\u00A0\u00A0\u00A0\nschema:dateModified<\/a> \"2020-03-16<\/span>\" ;\u00A0\u00A0\u00A0\nvoid:inDataset<\/a> <http:\/\/purl.oclc.org\/dataset\/WorldCat<\/a>> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n\n

Content-negotiable representations<\/p>\n