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Nucleic acid sensing and immunity. Part B

Author: Claire Vanpouille-Box; Lorenzo Galluzzi
Publisher: Cambridge, MA : Academic Press, 2019.
Series: International review of cell and molecular biology, v. 345.
Edition/Format:   eBook : Document : English : First editionView all editions and formats
Summary:
'Nucleic Acid Sensing and Immunity - PART B,' Volume 345 of the International Review of Cell and Molecular Biology series, gives a comprehensive overview of the nucleic acid machinery, from plants to mammalians, along with their regulation. Chapters in this updated volume include Nucleic acids sensing in allergic disorders, Nucleic acids sensing in autoimmune disorders, Nucleic acid sensing in inflammatory  Read more...
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Genre/Form: Electronic books
Additional Physical Format: (OCoLC)1048941152
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Claire Vanpouille-Box; Lorenzo Galluzzi
ISBN: 9780128159828 0128159820
OCLC Number: 1090539857
Description: 1 online resource.
Contents: Front Cover; Nucleic Acid Sensing and Immunity --
Part B; Copyright; Contents; Contributors; Nucleic Acid Sensing at the Interface Between Innate and Adaptive Immunity; Acknowledgments; Disclosures; References; Chapter One: Nucleic Acid Sensing in Allergic Disorders; 1. Introduction; 2. Categorizing Nucleic Acid Sensing Receptors Based on Mechanisms of Action (Table 1); 2.1. Group I Nucleic Acid Sensing Receptors; 2.1.1. TLRs, Membrane-Bound Pattern Recognition Receptors; 2.1.2. NLRs and Nucleic Acid Sensing; 2.1.3. AIM2 and cGAS; 2.2. Group II Nucleic Acid Sensing Receptors 2.3. Group III Nucleic Acid Sensing Receptors: RLRs3. Immune System and Nucleic Acid Sensing; 3.1. Nucleic Acid Sensing by Dendritic Cells; 3.2. Nucleic Acid Sensing by CD4 T Cells; 3.3. Nucleic Acid Sensing by B Cells; 4. Nucleic Acid Sensing by Epithelial Cells; 5. Viral Illness and Acute Asthma Exacerbations; 5.1. Rhinovirus; 5.2. Influenza Virus; 5.3. Respiratory Syncytial Virus (RSV); 6. Nucleic Acid-Based Therapies for Allergic Disorders; 7. Conclusions; Acknowledgment; References; Chapter Two: The Role of Nucleic Acid Sensing in Controlling Microbial and Autoimmune Disorders 1. Introduction2. RNA Nucleic Acid Sensing in Viral Immunology and Autoimmunity; 2.1. Detection of Intracellular RNA; 2.1.1. Protein Kinase R; 2.1.2. Toll-Like Receptors; 2.1.3. RIG-I-Like Receptors; 2.2. RNA Sensing During Viral Infections; 2.2.1. Hepatitis C Virus; 2.2.2. Dengue Virus and West Nile Virus; 2.2.3. Zika Virus; 2.2.4. Respiratory Syncytial Virus; 2.2.5. Nipah Virus; 2.2.6. Ebola Virus; 2.2.7. Rotavirus; 2.3. Defects in RNA Sensing and Autoimmunity; 2.3.1. The Role of MDA5 in Type 1 Diabetes and Aicardi-Goutières Syndrome; 2.3.2. P58, PERK, TLRs, and Type 1 Diabetes 2.3.3. Implication of RIG-I in Crohnś Disease2.3.4. Singleton-Merten Syndrome, Systemic Lupus Erythematosus, and Prolidase Disorder; 3. Intracellular Recognition of DNA; 3.1. A Central DNA-Sensing Pathway via cGAS and STING; 3.2. STING-Dependent Sensors: DDX41, Ku70, MRE11, and LSm14A; 3.2.1. DDX41; 3.2.2. Ku70; 3.2.3. MRE11; 3.2.4. LSm14A; 3.3. STING-Independent DNA Sensors: TLR9, RNA Polymerase III, DHX9/DHX36, AIM2, IFI16, Sox2, LRRFIP1, and Rad50; 3.3.1. TLR9; 3.3.2. RNA Polymerase III; 3.3.3. DHX9/DHX36; 3.3.4. AIM2 and IFI16; 3.3.5. Sox2, LRRFIP1, and Rad50 3.4. Autoimmune and Autoinflammatory Disorders Derived From Immune System Dysfunction3.5. DNA-Sensing Molecular Mechanisms of Diseases and Nucleic Acid Accumulation; 3.5.1. TLR9, TREX1, RNase H2, and SAMHD1; 3.5.2. Sjögrenś Syndrome; 3.6. Hypersensitivity of cGAS/STING Signaling; 3.6.1. SAVI and Familial Chilblain Lupus; 3.6.2. S6K1 and Multiple Sclerosis; 4. Prospective; Acknowledgments; References; Chapter Three: Nucleic Acid Induced Interferon and Inflammasome Responses in Regulating Host Defense to Gastrointestinal V ...; 1. The Viral Dimension of the Gut Microbiome
Series Title: International review of cell and molecular biology, v. 345.
Responsibility: edited by Claire Vanpouille-Box, Lorenzo Galluzzi.

Abstract:

'Nucleic Acid Sensing and Immunity - PART B,' Volume 345 of the International Review of Cell and Molecular Biology series, gives a comprehensive overview of the nucleic acid machinery, from plants to mammalians, along with their regulation. Chapters in this updated volume include Nucleic acids sensing in allergic disorders, Nucleic acids sensing in autoimmune disorders, Nucleic acid sensing in inflammatory disorders, Viral nucleic acid sensing inflammasomes in intestinal host defense, Genome damage sensing leads to tissue homeostasis in Drosophila, Nucleic acids sensing in plants, Nucleic Acid sensing in invertebrates, amongst other topics. Key Features: Provides an accurate, state-of-the-art resource on RNA sensing; Includes the work of a well-known tumor immunologist; Links intestinal host defense and viral nucleic acid sensing; Presents a chapter on the negative regulation of DNA sensing, a timely topic. Readership: Immunologists to tumor immunologists and DNA damage biologists. --

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