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The nude mouse in oncology research

Author: Epie Boven; B Winograd
Publisher: Boca Raton, FL : CRC Press, Taylor & Francis Group, [2018]
Series: CRC revivals.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
"The nude, athymic mouse (nu/nu) has become generally accepted as a valuable tool to study the biology and therapy of human cancers. This volume presents a critical review of the scientific merits of the animal as a recipient of human tumor tissue transplants. Important information is provided regarding biology, immunology, and measures for genetic and microbiological control of the nude mouse. The discussion of  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Epie Boven; B Winograd
ISBN: 9781351077217 135107721X 9781351094115 1351094114 9781351085700 1351085700 9781351102568 1351102567
OCLC Number: 1020790173
Description: 1 online resource.
Contents: Chapter 1 History and Pathology / Jørgen Rygaard --
chapter 2 Types of Immunodeficiency in Mice / Simon P. Langdon --
chapter 3 Breeding and Microbiological Control / Tatsuij Nomura --
chapter 4 Subcutaneous Xenografts / Jørgen Rygaard --
chapter 5 Tumorigenicity / J. C. Romijn --
chapter 6 Transplantability of Human Tumors / Øystein Fodstad --
chapter 7 Alternative Sites of Tumor Development / Epie Boven --
chapter 8 Characterization and Monitoring / Epie Boven --
chapter 9 Studies in Tumor Cell Biology / Simon P. Langdon --
chapter 10 Metastatic Models / Raffaella Giavazzi --
chapter 11 Experimental Therapy in Subcutaneous Transplants / David P. Houchens --
chapter 12 Radiotherapy / Einar K. Rofstad --
chapter 13 Conventional Chemotherapy / D. P. Berger --
chapter 14 Analogs of Conventional Agents / Epie Boven --
chapter 15 Investigational Agents / Ghanem Atassi --
chapter 16 Hormones / G.J. van Steenbrugge --
chapter 17 Monoclonal Antibodies / Hidde J. Haisma --
chapter 18 Cytokines / S. T. A. Malik --
chapter 19 Differentiation Inducers / Guus A. M. S. van Dongen --
chapter 20 Limitations for Studies in Human Tumor Biology / Øystein Fodstad --
chapter 21 Limitations for Treatment Studies / Boudewijn J. M. Braakhuis --
chapter 22 New Drug Development / Benjamin Winograd --
chapter 23 Preclinical Phase II Trials / H. H. Fiebig.
Series Title: CRC revivals.
Responsibility: editors Epie Boven, Benjamin Winograd.

Abstract:

"The nude, athymic mouse (nu/nu) has become generally accepted as a valuable tool to study the biology and therapy of human cancers. This volume presents a critical review of the scientific merits of the animal as a recipient of human tumor tissue transplants. Important information is provided regarding biology, immunology, and measures for genetic and microbiological control of the nude mouse. The discussion of transplantation sites and transplantability of human tumor tissue to the animals includes both the description of host factors and the tumor type involved. The characterization and monitoring of xenografts is followed by a review on their possible application for studies in tumor biology, such as hormones, growth factors, drug resistance, tumor markers, and heterogeneity. Experimental therapy is dedicated to cytostatic agents, hormones, monoclonal antibodies, cytokines, differentiation inducers and radiotherapy. The book also provides critical remarks regarding the limitation of the nude-mouse tumor models. The Nude Mouse in Oncology Research will provide essential reference information for oncology researchers, researchers who work with the nude mouse on a regular basis, and pharmaceutical companies."--Provided by publisher.

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