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ODE/PDE a-synuclein models for Parkinson's disease

Author: W E Schiesser
Publisher: Amsterdam : Academic Press, 2018.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
ODE/PDE Alpha-Synuclein Models for Parkinson's Disease discusses a mechanism for the evolution of Parkinson's Disease (PD) based on the dynamics of the protein?-synuclein, a monomer that has been implicated in this disease. Specifically,?-synuclein morphs and aggregates into a polymer that can interfere with functioning neurons and lead to neurodegenerative pathology. This book first demonstrates computer-based  Read more...
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Additional Physical Format: Print version :
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: W E Schiesser
ISBN: 9780128148020 0128148020
OCLC Number: 1028193737
Notes: 1. Introduction, ODE Model Formulation 2. Introduction, ODE Model Application 3. Introduction, ODE/PDE Model Formulation 4. Introduction, ODE/PDE Model Application 5. Introduction, Convection-Diffusion-Reaction Model Formulation 6. Introduction, Convection-Diffusion-Reaction Model Application 7. Introduction, Forward and Reverse Axonal Transport Appendix A1: Function dss012 Appendix A2: Function dss044.
Description: 1 online resource
Contents: 1. Introduction, ODE Model Formulation 2. Introduction, ODE Model Application 3. Introduction, ODE/PDE Model Formulation 4. Introduction, ODE/PDE Model Application 5. Introduction, Convection-Diffusion-Reaction Model Formulation 6. Introduction, Convection-Diffusion-Reaction Model Application 7. Introduction, Forward and Reverse Axonal Transport Appendix A1: Function dss012 Appendix A2: Function dss044
Responsibility: William E. Schiesser.

Abstract:

ODE/PDE Alpha-Synuclein Models for Parkinson's Disease discusses a mechanism for the evolution of Parkinson's Disease (PD) based on the dynamics of the protein?-synuclein, a monomer that has been implicated in this disease. Specifically,?-synuclein morphs and aggregates into a polymer that can interfere with functioning neurons and lead to neurodegenerative pathology. This book first demonstrates computer-based implementation of a prototype ODE/PDE model for the dynamics of the?-synuclein monomer and polymer, and then details the methodology for the numerical integration of ODE/PDE systems which can be applied to computer-based analyses of alternative models based on the reader's interest. This book facilitates immediate computer use for research without the necessity to first learn the basic concepts of numerical analysis for ODE/PDEs and programming algorithms.

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