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Genre/Form: | Thèses et écrits académiques |
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Additional Physical Format: | Optimisation du procédé de lyophilisation du complexe lipoprotéïque DC-Chol/Uréase / Pierre Chouvenc Lille : Atelier national de reproduction des thèses, 2004 Microfiches. (@Lille-Thèses) (ABES)259576131 |
Material Type: | Thesis/dissertation |
Document Type: | Book |
All Authors / Contributors: |
Pierre Chouvenc; Julien Andrieu; Université Claude Bernard (Lyon). |
OCLC Number: | 690557318 |
Notes: | Thèse confidentielle jusqu'en janvier 2006. |
Description: | 1 vol. (233 f.) : ill. en coul. ; 30 cm. |
Responsibility: | Pierre Chouvenc ; sous la direction de Julien Andrieu. |
Abstract:
After a short description of the heat and mass transfer phenomena occurring during the freeze-drying process, the importance of glassy state during pharmaceuticals freeze-drying was presented. A state of the art of liposomes and proteins formulation and freeze-drying was then set out. The DC-Chol/Urease complex, a potential vaccine again Helicobacter Pylori bacteria, was formulated and its freeze-drying process was optimised. The thermophysical properties (state diagram) of the optimal matrix selected were determined. Then, two original methods of frozen structure characterization (Cold chamber microscopy and NMR micro-imaging) were developed and applied to study the effect of annealing on average ice crystals size and to optimize the freezing step. A new pressure rise analysis model (PRA model) was validated to monitor the product temperature, and then adapted to freeze-dryers equipped with a slow motion separating valve. Finally, the kinetics of the secondary drying period were investigated.
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