Pediatric Inflammatory Bowel Disease: from diagnosis to transition (Book, 2012) [WorldCat.org]
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Pediatric Inflammatory Bowel Disease: from diagnosis to transition

Author: Charlotte Bie
Publisher: Erasmus University Rotterdam 2012-09-07
Edition/Format: Book Book : English
Summary:
textabstractThe inflammatory bowel diseases (IBD) are chronic relapsing inflammatory disorders ofthe gastrointestinal tract, comprising Crohn’s disease (CD), ulcerative colitis (UC), andIBD-unclassified (IBD-U). CD is characterized by a transmural and often granulomatousinflammation that can involve any part of the gastrointestinal tract in a discontinuousmanner, while UC is defined as a chronic inflammatory  Read more...
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Details

Document Type: Book
All Authors / Contributors: Charlotte Bie
ISBN: 978-94-6191-367-8
Language Note: English
Unique Identifier: 6892888178
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Abstract:

textabstractThe inflammatory bowel diseases (IBD) are chronic relapsing inflammatory disorders ofthe gastrointestinal tract, comprising Crohn’s disease (CD), ulcerative colitis (UC), andIBD-unclassified (IBD-U). CD is characterized by a transmural and often granulomatousinflammation that can involve any part of the gastrointestinal tract in a discontinuousmanner, while UC is defined as a chronic inflammatory condition causing continuousmucosal inflammation of the colon, without granulomas on biopsy, affecting the rectumand a variable extent of the colon in continuity. The term IBD-U is used for patientspresenting with IBD restricted to the colon without the specific features of either CD or UC.2Early-onset IBD represents a distinct disease entity with differences in disease type,disease location, disease behavior, gender preponderance, and genetically attributablerisk compared with late-onset IBD. As in adults, treatment of early-onset IBD is aimed atinducing and maintaining remission, but special considerations are needed regardingoptimal growth, pubertal development, and the transition period to adult care. A betterunderstanding of the differences between early-onset and late-onset IBD will eventuallylead to a better understanding of the pathogenesis of the disease. One of the limitations ofstudying pediatric IBD is however that a relatively small number of patients is available forstudy at one institution, which requires ongoing collaborations between many institutions.This thesis will present six (inter)national multicenter studies, a single-center pilot studyand a review, which all focus on the unique clinical aspects of pediatric IBD, therebycomplementing the relatively small body of literature on the diagnosis and treatment ofchildren with IBD.

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