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Perinatal psychopharmacology

Author: Faruk Uguz; Laura Orsolini
Publisher: Cham, Switzerland : Springer, 2019.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
This book focuses on recent advances in research and practical recommendations regarding the use of psychotropic drugs during pregnancy and lactation, two important social and psychological life events for women. In addition to the social context, including the addition of a new family member, many women experience the occurrence or recurrence of psychiatric disorders during the perinatal period. Psychiatric  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Printed edition:
Printed edition:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Faruk Uguz; Laura Orsolini
ISBN: 9783319929194 3319929194 9783319929200 3319929208
OCLC Number: 1084251933
Description: 1 online resource (viii, 376 pages)
Contents: Intro; Preface; Contents; Part I: Introduction to Perinatal Psychopharmacology; 1: Epidemiology of the Use of Psychotropic Drugs in Pregnant and Nursing Women; 1.1 Introduction; 1.2 Psychopharmacology in Pregnancy and Breastfeeding; 1.2.1 Antidepressants; 1.2.1.1 Selective Serotonin Reuptake Inhibitors; 1.2.1.2 Bupropion; 1.2.1.3 Other Less Commonly Used Antidepressants; 1.2.2 Anxiolytics; 1.2.3 Antipsychotics; 1.2.3.1 First-Generation Antipsychotics (FGAs); 1.2.3.2 Second-Generation Antipsychotics (SGAs); 1.2.4 Mood Stabilizers; 1.2.5 Stimulants; 1.3 Conclusion; References 2: Maternal and Infant Pharmacokinetics of Psychotropic Medications During Pregnancy and Lactation2.1 Pharmacokinetics of Pregnancy; 2.1.1 Pharmacokinetics of the Pregnant Woman; 2.1.2 Pharmacokinetics of the Fetus and the Neonate; 2.1.3 Pharmacokinetics of Anxiolytics in Pregnancy; 2.1.4 Pharmacokinetics of Antidepressants in Pregnancy; 2.1.5 Pharmacokinetics of Antipsychotics in Pregnancy; 2.1.6 Pharmacokinetics of Mood Stabilizers in Pregnancy; 2.1.7 Pharmacokinetics of Opioids in Pregnancy; 2.2 Pharmacokinetics of Lactation; 2.2.1 Pharmacokinetics in the Lactating Mother 2.2.2 Drug Excretion to the Breast Milk2.2.3 Pharmacokinetics of Nursing Infant; 2.2.4 Pharmacokinetics of Anxiolytics and Hypnotics During Lactation; 2.2.5 Pharmacokinetics of Antidepressants During Lactation; 2.2.6 Pharmacokinetics of Antipsychotics During Lactation; 2.2.7 Pharmacokinetics of Mood Stabilizers During Lactation; 2.2.8 Opioid Pharmacokinetics During Lactation; 2.3 Conclusions; References; 3: Safety Parameters and Risk Categories Used for Psychotropic Drugs in Pregnancy and Lactation; 3.1 Introduction; 3.2 Pregnancy Risk Categories 3.3 Criticisms Regarding the FDA Pregnancy Risk Categories3.4 Assessing the Possible Teratogenic Risk of Medications; 3.4.1 Variables Related with the Administration of the Medication; 3.4.1.1 Time of Administration; 3.4.1.2 Dose of Medication; 3.4.1.3 Route of Administration; 3.4.1.4 Monotherapy vs. Polytherapy; 3.4.2 Evaluating the Data; 3.4.2.1 Experimental Studies; Animal Studies; 3.4.2.2 Human Studies; Case Reports; Epidemiologic Studies; Meta-Analysis; 3.4.2.3 Methodological Issues; Sample Size, Characteristics, and Follow-Up; Recall Bias; Confounders Confounding by IndicationMeta-Analysis; 3.4.2.4 Important Points to Consider for Medication Use During Pregnancy; 3.5 Lactation; 3.5.1 Factors Influencing the Passage of the Medication into the Breastmilk and Infant Exposure; 3.5.1.1 Maternal Plasma Concentration and Plasma Protein Binding; 3.5.1.2 Size of the Molecule; 3.5.1.3 Degree of Ionization; 3.5.1.4 Lipid Solubility; 3.5.1.5 Pharmacogenomics; 3.5.1.6 Oral Bioavailability; 3.5.1.7 The Age of the Infant; 3.5.2 Effect of Medications on Milk Production; 3.5.3 Calculating and Interpreting Infant Exposure
Responsibility: Faruk Uguz, Laura Orsolini, editors.

Abstract:

This book focuses on recent advances in research and practical recommendations regarding the use of psychotropic drugs during pregnancy and lactation, two important social and psychological life events for women. In addition to the social context, including the addition of a new family member, many women experience the occurrence or recurrence of psychiatric disorders during the perinatal period. Psychiatric disorders during this period can have negative effects on the fetus, infant and other children in the family, and can result in functional impairment among mothers. The book offers a comprehensive overview of psychopharmacological treatments for nearly all specific psychiatric conditions (e.g. bipolar disorder, panic disorder, obsessive-compulsive disorder) and includes chapters on clinical approaches to treating these disorders. As such, it will appeal to a wide readership, including psychiatrists, obstetricians, gynecologists and pediatricians.

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