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  E-mail Message: I thought you might be interested in this item at http://www.worldcat.org/oclc/799430400 Title: Periostat for periodontal disease : a review of the clinical effectiveness, cost effectiveness and guidelines Publisher: [Ottawa, Ont.] : Canadian Agency for Drugs and Technologies in Health, 2012. OCLC:799430400

  
  

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Periostat for periodontal disease : a review of the clinical effectiveness, cost effectiveness and guidelines

Author:	Canadian Agency for Drugs and Technologies in Health.
Publisher:	[Ottawa, Ont.] : Canadian Agency for Drugs and Technologies in Health, 2012.
Series:	Rapid response report.
Edition/Format:	eBook : Document : EnglishView all editions and formats
Summary:	Periodontal disease is a common condition which may be classified as either gingivitis or periodontitis. Patients with gingivitis have gingival inflammation, redness, and bleeding with probing, brushing or flossing. Periodontitis includes gingivitis and loss of supportive tissues including alveolar bone. As a result, there is a loss of attachment of teeth and a probe placed between the gingiva and tooth structures will show increased probing depth. Bone loss around the teeth is detectable on radiographs. Progression of disease may lead to increased tooth mobility and tooth loss. Periodontal disease is closely associated with oral hygiene and is often preventable. Treatment includes good dental hygiene, and scaling and root planing by a dental professional to remove subgingival plaque. Adjunctive therapies include topical or systemic antibiotics. Low dose doxycycline (Periostat 20 mg twice daily) is thought to inhibit collagenase activity and prevent breakdown of connective tissue and alveolar bone in patients with periodontitis. This report will review the evidence on the clinical effectiveness, cost-effectiveness and guidelines for use of doxycycline (Periostat) to inform funding decisions by drug programs.  Read more...
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Subjects	Tetracyclines -- Derivatives -- Therapeutic use. Periodontal disease -- Chemotherapy. Cost effectiveness. View all subjects
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