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Peroxynitrite detection in biological media : challenges and advances

Author: Serban Peteu; Sabine Szunerits; Mekki Bayachou; Royal Society of Chemistry (Great Britain)
Publisher: [Cambridge] : Royal Society of Chemistry, [2015] ©2016
Series: RSC detection science series, no. 7.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Peroxynitrite is a powerful oxidiser which can damage a wide array of molecules within cells, including DNA and proteins, leading to apoptosis, inflammation or cancer. Peroxynitrite detection and quantification provides critical information in understanding its biological implications. Attempts to investigate the behavior of peroxynitrite in vivo and in vitro have been hampered by the difficulty in detecting this  Read more...
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Genre/Form: Electronic books
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Serban Peteu; Sabine Szunerits; Mekki Bayachou; Royal Society of Chemistry (Great Britain)
ISBN: 9781782622352 1782622357
OCLC Number: 929952650
Language Note: English.
Notes: Includes index.
Description: 1 online resource.
Contents: Cover; Peroxynitrite Detection in Biological Media Challenges and Advances; Preface; Dedication; Contents; Chapter 1 --
Peroxynitrite: The Basics; 1.1 History; 1.1.1 Before 1990; 1.1.2 1990 and Later; 1.2 Peroxynitrite In Vivo; 1.3 Challenges to the Detection of Peroxynitrite; 1.4 Nomenclature; Acknowledgements; References; Chapter 2 --
Quantifying Peroxynitrite: Bridging the Gap Between Chemistry, Biology and Immunology; 2.1 General Remarks on the Concept of "Redox Signaling"; 2.2 The Basic Chemical Properties of Peroxynitrite Compared with Other RNS/ROS as Signaling Molecules 2.3 The Complex Interplay of Peroxynitrite and Other RNS/ROS in Biological Systems2.4 Implications of Selecting a Model System for In Vitro, In Vivo and Ex Vivo Experiments; 2.4.1 Use of Biological Sample Materials; 2.4.2 Performing Cell Culture Studies; 2.4.3 Use of Scavengers, Pharmaceuticals or Enzymes to Alter Peroxynitrite Signaling Pathways; 2.5 General Challenges of Detecting RNS and ROS: The Complexity of the Task to Quantify Peroxynitrite in Biological Samples; 2.5.1 Overview of the Different Quantification Approaches 2.5.2 Parameters Impacting the Performance of ONOO− Quantification2.6 Conclusions; Acknowledgements; References; Chapter 3 --
Methods of Peroxynitrite Synthesis in the Context of the Development and Validation of Peroxynitrite Sensors; 3.1 Background; 3.2 Overview of Major Methods of Peroxynitrite Synthesis; 3.2.1 Peroxynitrite from the Reaction of Nitrite with Acidified Hydrogen Peroxide; 3.2.2 Synthesis of Peroxynitrite in a Two-Phase System Using Isoamyl Nitrite and H2O2; 3.2.3 The Reaction of H2O2 and Water Soluble Nitrites such as 2-Ethoxyethyl Nitrite in Basic Medium 3.2.4 The Reaction of Ozone with Azide Ions in the Presence of a Low Concentration of Alkali3.2.5 Other Methods of Peroxynitrite Synthesis; 3.2.6 Generation of Peroxynitrite from 3-(4-Morpholinyl) Sydnonimine Hydrochloride; 3.3 Advantages and Limitations of the Various Peroxynitrite Synthesis Routes; 3.3.1 Characterization of Peroxynitrite Sensors and Evaluation of Performance: Are Buffers Indifferent; 3.3.2 Advantages and Limitations of the Various Methods of Peroxynitrite Synthesis and Generation for Sensing Purposes; References Chapter 4 --
Peroxynitrite-Sensitive Electrochemically Active Matrices4.1 Introduction: Challenges for the Formation of Selective and Sensitive Matrices for Peroxynitrite Detection; 4.2 Polymeric Films; 4.2.1 Metallophthalocyanine Films (MPCs); 4.2.2 Porphyrins; 4.2.3 Conducting Polymers; 4.3 Graphene-Based Matrices; 4.4 Conclusion and Perspectives; Acknowledgements; References; Chapter 5 --
Electrochemical Detection of Peroxynitrite in Biological Solutions: Challenges and Perspectives; 5.1 Challenges in the Detection of Peroxynitrite in Biological Conditions
Series Title: RSC detection science series, no. 7.
Responsibility: editors: Serban Peteu, Sabine Szunerits, Mekki Bayachou.

Abstract:

Peroxynitrite detection and quantification provides critical information in understanding its biological implications. It will be welcomed by the community particularly medicinal and analytical  Read more...

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