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Pharmaceutical formulation : the science and technology of dosage forms

Author: Geoffrey D Tovey
Publisher: Cambridge : Royal Society of Chemistry, 2018
Series: RSC drug discovery series, 64.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Pharmaceutical Formulation provides an up to date source of information for all who wish to understand the principles and practice of formulation in the drug industry.
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Genre/Form: Electronic books
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Geoffrey D Tovey
ISBN: 9781782620402 1782620400 9781523122899 1523122897
OCLC Number: 1042220679
Notes: Includes index.
Title from title details screen.
Description: 1 online resource (409 pages)
Contents: Intro; Title Page; Copyright Page; Preface; Contents; Chapter 1 Preformulation Studies; 1.1 Introduction; 1.2 Solubility; 1.2.1 Absolute (Intrinsic) Solubility; 1.2.2 Molecular Dissociation pKa; 1.2.3 Solubility in Various Solvents; 1.2.4 Solubility Rate (Dissolution); 1.3 Diffusion; 1.4 Partition Coefficient; 1.5 Permeability; 1.6 The Biopharmaceutical Classification System; 1.7 Moisture Uptake/Sorption; 1.7.1 Classification of Hygroscopicity; 1.8 Polymorphism and Crystallinity; 1.8.1 Differential Scanning Calorimetry (DSC); 1.8.2 Thermogravimetric Analysis (TGA) 1.8.3 Powder X-ray Diffraction1.8.4 Crystallinity; 1.9 Stability; 1.9.1 Chemical Degradation in Solution; 1.9.2 Hydrolytic Degradation; 1.9.3 Stability in Solvents Used in Formulation and/or Manufacture; 1.9.4 Dimerization and Polymerisation; 1.9.5 Photostability; 1.9.6 pH-dependent Stability; 1.9.7 Oxidative Stability; 1.9.8 Stability-Compatibility; 1.10 Solid-state Physico-Technical Properties; Further Reading; References; Chapter 2 Hard Capsules in Modern Drug Delivery; 2.1 Introduction; 2.2 Hard Capsules-Types, Characteristics and Applications 2.2.1 Hard Capsules as a Pharmaceutical Excipient2.2.2 Hard Capsules for Special Applications; 2.3 Selection of Capsules in Formulation Development; 2.4 Hard Capsule Drug Delivery Addressing Pharmaceutical Needs; 2.4.1 Hard Capsule Powder Blend Formulation and Processing; 2.4.2 Highly Potent and Low-dose Drug Formulations; 2.4.3 Enhancing Bioavailability of Poorly Aqueous Soluble Drugs; 2.4.4 Physical Modification of the Drug Substance; 2.5 Targeted Drug Delivery; 2.5.1 Capsules with Solid Formulation; 2.5.2 Abuse Deterrent; 2.6 Manufacture of Commercial Hard Capsules Products 2.6.1 Powder and Granule Blends2.6.2 Multiparticulates and Mini-tablets; 2.6.3 Tablet Filling; 2.6.4 Liquid and Semi-solid Formulation; 2.6.5 Powder Micro-dosing; 2.7 Conclusions; Acknowledgements; References; Chapter 3 Soft Capsules; 3.1 Introduction; 3.2 Background; 3.3 Technology Strengths/Limitations; 3.4 Description; 3.5 Equipment and Facilities; 3.6 Shell Components; 3.7 Fill Formulation; 3.8 Product Development; 3.8.1 Fill Formulation Development Processes; 3.8.2 Shell Compatibility; 3.8.3 Prototype Manufacture; 3.8.4 Process Development; 3.9 Clinical Supply 3.10 Analytical Considerations3.11 Excipient Considerations; 3.11.1 Gelatin; 3.11.2 Plasticizers; 3.11.3 Water; 3.11.4 Colors, Opacifiers etc.; 3.11.5 Ingredient Specifications; 3.12 Packaging and Stability Considerations; 3.13 Manufacturing Process; 3.14 Key Process and Product Parameters; 3.14.1 In-process Testing; 3.14.2 Set up (Pre-start); 3.14.3 During Encapsulation; 3.14.4 During Drying; 3.14.5 Finished Product; 3.15 Recent Technology Advances; 3.15.1 Film Coating; 3.15.2 Non-gelatin Shell and Controlled Release Fill; 3.15.3 Vaginal Dosage Forms; 3.16 Trends in Patent Activity
Series Title: RSC drug discovery series, 64.
Responsibility: editors: Geoffrey D. Tovey.

Abstract:

Pharmaceutical Formulation provides an up to date source of information for all who wish to understand the principles and practice of formulation in the drug industry.  Read more...

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