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Pharmaceutics

Author: Shelley Chambers Fox
Publisher: London : Pharmaceutical Press, [2014]
Series: Remington education
Edition/Format:   Print book : EnglishView all editions and formats
Summary:

Remington Education: Pharmaceutics covers the basic principles of pharmaceutics, from dosage forms to drug delivery and targeting. It addresses all the principles covered in an introductory pharmacy  Read more...

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Details

Document Type: Book
All Authors / Contributors: Shelley Chambers Fox
ISBN: 9780857110701 0857110705
OCLC Number: 906780273
Notes: Comprend un index.
Description: xiv, 539 pages : illustrations ; 24 cm.
Contents: Introduction --
Properties of the drug --
Qualities of the ideal dosage form --
Pharmaceutical necessities --
Properties of the routes of administration --
Routes of administration --
Parenteral routes --
Enteral routes --
Rectal and vaginal routes --
Drugs applied to the skin --
Inhalation routes: nasal and lung --
Liberation, absorption, distribution, metabolism and elimination (LADME) --
Drug liberation --
Drug absorption and patterns of drug release --
Drug distribution --
Drug elimination --
Introduction --
Solid state, forces between ions and molecules, and physical properties of drugs --
Types of attractive forces --
Repulsive forces --
Melting point --
Polymorphs --
Crystalline habit --
Solvates --
Cocrystals --
Amorphous solids --
Drug salts --
Drug derivatives --
Surface interactions and the pharmaceutical properties of drugs --
Particle size --
Adsorption --
Hygroscopicity and deliquescence --
Particle interactions and surface energy --
Powder flow and its improvement --
Solubility and dissolution --
Melting point, solubility and dissolution rate --
Predicting water solubility from desirable drug-water interactions --
Partitioning behavior of drug molecules: Log P --
Measurement of solubility --
Methods of expressing solubility --
Dissolution of solids --
Introduction --
Behavior of molecular solutions, colloidal dispersions, and coarse dispersions --
Colloidal dispersions --
Coarse dispersions --
Interfacial (surface) behavior of the dispersed phase --
Flow and viscosity --
Newtonian flow --
Non-Newtonian flow --
Gels --
Introduction --
Why solubility is important --
Colligative properties of molecular solutions --
osmotic pressure of drug solutions --
Solute structure and number of dissolved particles --
Osmolality and osmolarity --
Tonicity and isotonicity --
Calculating tonicity of drug solutions using E value --
E value --
USP volume --
Manipulation of solubility --
Solubility and pH --
Predicting whether a drug will be water soluble or membrane soluble at a given pH --
Manipulation of solubility with cosolvents --
Solid state manipulation --
Solubilizing agents --
Introduction --
Common pathways of drug degradation --
Small drug molecules --
Hydrolysis --
Oxidation --
Photolysis --
Racemization --
Protein drug degradation --
Protein drug molecules --
DNA and RNA molecules --
Rates of drug degradation reactions --
Rate of drug degradation --
Shelf life --
Factors that affect shelf life --
Managing chemical stability problems --
Formulation changes --
Storage conditions --
Packaging --
Introduction --
Physicochemical factors --
Water solubility --
Log P --
Log D --
pH/pKa --
Molecular weight --
Biological factors --
Membrane structure and transport mechanisms --
Movement of drugs across membranes --
Passive diffusion --
Drug transporters --
Endocytosis and transcytosis --
Receptor mediated cytosis --
Permeability of absorptive membranes --
Blood flow, tissue perfusion, and other modes of distribution --
Tissue and plasma protein binding --
Drug metabolism --
Management of drug interactions --
Dosage form factors --
Release from the dosage form --
Release of drug by dissolution --
Release of drug by diffusion --
Dosage form design --
Patient factors --
Following a drug from administration to elimination --
Introduction --
Pharmaceutical equivalence + bioequivalence = therapeutic equivalence --
Bioavailability --
Dissolution rate data --
Bioequivalence of systemically available drug products --
Bioequivalence of products that produce local effects --
Using the FDA Orange Book --
Biopharmaceutical Classification System --
Water solubility revisited --
Permeability and human intestinal absorption --
Biopharmaceutical Drug Disposition Classification System --
Introduction --
Characteristics of parenteral administration routes --
Intravenous route --
Intramuscular injection --
Subcutaneous injection --
Intradermal administration --
Intra-arterial administration --
Injection into the central nervous system --
Intra-articular administration --
Drug properties --
Parenteral dosage forms --
Design of parenteral dosage forms --
Release characteristics --
Immediate release dosage forms --
Sustained release dosage forms --
Preparation and handling of parenteral products --
Industrial processes --
Preparation of sterile products in the pharmacy --
Quality assurance --
Parenteral stability/compatibility --
Beyond-use dates for parenteral products --
Types of incompatibilities --
Parenteral compatibility checklist --
Patient counseling --
Intradermal injections --
Subcutaneous injections --
Intramuscular injections --
Introduction --
Physicochemical and biological properties --
Peptide and protein drugs --
Oligonucleotide and transgene drugs --
Movement from administration site to target --
Design of delivery systems --
Polymer based systems --
Liposomes and lipoplexes --
Viral vectors --
Passive targeting --
Active targeting --
Biosimilars --
Introduction --
Characteristics of the ophthalmic route --
Drug travel from dosage form to target --
Drug properties and the eye --
Dosage forms for the ophthalmic route --
Design of dosage forms for the anterior segment --
Design of dosage forms for the posterior segment --
Ingredients --
Preparation --
Quality evaluation and assurance --
Counseling patients --
Administration to the front of the eye --
Solutions, suspensions and gel forming solutions --
Ophthalmic ointment and gels --
Introduction --
Characteristics of the oral cavity route --
Drug travel from dosage form to target --
Drug properties and the oral cavity --
Oral cavity dosage forms --
Design --
Ingredients --
Dosage forms for local treatment of the mouth --
Dosage forms for systemic targets --
Quality evaluation and assurance --
Counseling patients --
Solutions and suspensions --
Pastes and gels --
Patches and films --
Sublingual aerosols --
Sublingual tablets --
Buccal tablets --
Gum --
Introduction --
Characteristics of the gastrointestinal route --
Drug travel from dosage form to target --
Dosage forms in the stomach --
Dosage forms in the small intestine --
Effect of disease states on drug absorption --
Drug properties and the gastrointestinal route --
Immediate release dosage forms: oral liquids --
Design --
Ingredients --
Preparation --
Beyond-use dates --
Quality assurance --
Immediate release dosage forms: oral solids --
Design --
Tablet designs and ingredients --
Capsule designs --
Preparation of tablets and capsules --
Tablet splitting --
Quality evaluation and assurance --
Counseling patients --
Oral liquids --
Tablets and capsules --
Orally disintegrating tablets --
Food advice --
Introduction --
Characteristics of modified release oral solids --
Theory behind dissolution controlled and diffusion controlled release --
Drug travel from dosage form to target --
Drug properties that influence modified release dosage solids --
Dosage forms of modified release oral solids --
Delayed release designs --
Extended release designs --
Quality evaluation and assurance --
Counseling patients --
Delayed release solids --
Extended release solids --
Introduction --
Characteristics of the rectal route --
Drug travel from rectal dosage form to target --
Drug properties and the rectal route --
Characteristics of the vaginal route --
Drug travel from vaginal dosage form to target --
Drug properties and the vaginal route --
Dosage forms for the rectal and vaginal routes --
Design of rectal and vaginal liquids --
Design of gels, creams and foams --
Design of suppositories and tablets --
Design of ring inserts --
Over-the-counter anorectal products --
Quality evaluation and assurance --
Counseling patients --
Rectal dosage forms --
Vaginal dosage forms --
Introduction --
Characteristics of the nasal route --
Drug travel from dosage form to target --
Drug properties and the nasal route --
Dosage forms for the nasal route --
Design --
Dosage forms and devices --
Quality evaluation and assurance --
Counseling patients --
Nose drops --
Nasal metered dose pumps --
Introduction --
Characteristics of the respiratory route --
Drug travel from dosage form to target --
Drug properties and the respiratory route --
Dosage forms for the respiratory route --
Design --
Aerosol ingredients and devices --
Quality evaluation and assurance --
Counseling patients --
Choosing an aerosol generating device --
Use of aerosol devices --
Use of metered dose inhalers --
Use of dry powder inhalers --
Use of a nebulizer --
Introduction --
Characteristics of the dermal route --
Drug travel from dosage form to target --
Distribution --
Drug properties and the dermal route --
Dosage forms for the dermal route --
Design --
Fick's law --
Influence of formulation on flux --
Patient factors --
Dosage forms --
Preparation --
Quality evaluation and assurance --
Doses of dermatological products --
Counseling patients --
Introduction --
Characteristics of the transdermal route --
Drug travel from dosage form to target --
Drug properties and the transdermal route --
Dosage forms for the transdermal route --
Design --
Ingredients --
Dosage forms --
Quality evaluation and assurance --
Dosage forms: Regional transdermal systems --
Compounded formulations for transdermal applications --
Counseling healthcare providers and patients --
Advising healthcare providers about patches --
Advising patients about the use of patches.
Series Title: Remington education
Responsibility: Shelley Chambers Fox.

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"Many chapters include patient counselling tips, which should be helpful for students. Providing examples of marketed products based on the delivery technology discussed in the chapter makes the Read more...

 
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